A5066774133- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Sepsis Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Electrolyte and hormonal disorders
- Venous Thromboembolism Diagnosis and Management
- Coronary Interventions and Diagnostics
- Emergency and Acute Care Studies
- Systemic Lupus Erythematosus Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Inflammation biomarkers and pathways
- Cardiac Arrest and Resuscitation
- Immune Response and Inflammation
- Epilepsy research and treatment
- Rheumatoid Arthritis Research and Therapies
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- Cardiac Arrhythmias and Treatments
- HIV/AIDS drug development and treatment
- Monoclonal and Polyclonal Antibodies Research
- Pneumonia and Respiratory Infections
Hôpital Cochin
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Laboratoire de Biochimie
2024
Université Paris Cité
2011-2023
Délégation Paris 5
2010-2022
Descartes (Belgium)
2022
Hôpital Broca
2011-2021
Columbus Oncology and Hematology Associates
2019-2021
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2009-2019
Sorbonne Paris Cité
2013-2019
Interferons interfere with lung repair (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), engage various functions. Type I IFNs (IFN-α and IFN-β) widely expressed can result immunopathology during viral infections. By contrast, type III (IFN-λ) responses primarily restricted mucosal surfaces thought confer protection without driving damaging proinflammatory responses. Accordingly, IFN-λ...
Abstract Background Coronavirus disease 2019 (Covid-19) is a major global threat that has already caused more than 100,000 deaths worldwide. It characterized by distinct patterns of progression implying diverse host immune response. However, the immunological features and molecular mechanisms involved in Covid-19 severity remain so far poorly known. Methods We performed an integrated analysis included in-depth phenotypical profiling cells, whole-blood transcriptomic cytokine quantification...
Objective: We aimed to investigate the prognostic performances of oxidative stress (OS), inflammatory and cell activation biomarkers measured at admission in COVID-19 patients. Design: retrospective monocentric study. Setting: patients with suspected SARS-CoV-2 infection (COVID-19) admitted hospital. Patients: One hundred sixty documented unselected COVID-19-patients. Disease severity (from mild critical) was scored according NIH’s classification. Interventions: none. Measurements main...
Recent guidelines recommend the immediate performance of a coronary angiography when an acute myocardial infarction is suspected as cause out-of-hospital cardiac arrest. However, prehospital factors such postresuscitation electrocardiogram pattern or clinical features are poorly sensitive in this setting. We searched to evaluate if early measurement troponin I can help detect recent occlusion arrest.Retrospective analysis prospective electronic registry database.University arrest...
Abstract Introduction Community-acquired pneumonia (CAP) requires prompt treatment, but its diagnosis is complex. Improvement of bacterial CAP by biomarkers has been evaluated using chest X-ray infiltrate as the gold standard, producing conflicting results. We analyzed diagnostic accuracy in suspected adults visiting emergency departments for whom was established an adjudication committee which founded judgment on a systematic multidetector thoracic CT scan. Methods In ancillary study...
Abstract Introduction Recently, newer assays for cardiac troponin (cTn) have been developed which are able to detect changes in concentration of the biomarker at or below 99th percentile a normal population. The objective this study was compare diagnostic performance new high-sensitivity T (HsTnT) assay that conventional cTnI diagnosis acute myocardial infarction (AMI) according pretest probability (PTP). Methods In consecutive patients who presented our emergency departments with chest pain...
To measure plasma concentrations of high-sensitivity cardiac troponin T (HS-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with systemic sclerosis (SSc; scleroderma) age- sex-matched healthy control subjects, to examine the contribution traditional cardiovascular risk factors SSc features these 2 biomarkers.Plasma HS-cTnT NT-proBNP were measured using electrochemiluminescence method sandwich immunoassay, respectively.The study group comprised 161 unrelated 213...
Objective. To measure concentrations of high-sensitivity cardiac troponin (HS-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with rheumatoid arthritis (RA) to examine correlates. Methods. The plasma HS-cTnT NT-proBNP were measured consecutive RA compared values obtained from age-matched sex-matched healthy controls. Results. We included 236 unrelated (192 females, 57 ± 13 yrs) 213 controls (170 55 15 yrs). Seventy-one free cardiovascular (CV) risk factors....
Abstract Aims B-type natriuretic peptide (BNP) and mid-regional pro-atrial (MR-proANP) testing are guideline-recommended to aid in the diagnosis of acute heart failure. Nevertheless, diagnostic performance these biomarkers is uncertain. Methods We performed a systematic review individual patient-level data meta-analysis evaluate BNP MR-proANP. subsequently developed externally validated decision-support tool called CoDE-HF that combines concentrations with clinical variables using machine...
Objective The clinical relevance of antiphospholipid antibodies (aPLs) in COVID‐19 is controversial. This study was undertaken to investigate the prevalence and prognostic value conventional nonconventional aPLs patients with COVID‐19. Methods a multicenter, prospective observational French cohort hospitalized suspected Results Two hundred forty‐nine were COVID‐19, whom confirmed 154 not 95. We found significant increase lupus anticoagulant (LAC) positivity among compared without (60.9%...
Presepsin could help for early diagnosis of systemic infection. Little is known regarding its kinetics. We studied presepsin concentration after challenge with bacterial agonist lipopolysaccharide (LPS) stimulation in peripheral mononuclear cells (PMNC) collected from 5 healthy volunteers and a human cell line monocytic (THP1). In PMNC, an exposure to LPS (100 ng/mL) induced increase median levels as hour 1 (+31%, p=0.007), concomitantly IL-6 synthesis. THP1 cells, was detected at exposure,...