Tobias Reichlin
A5090502339- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- ECG Monitoring and Analysis
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiomyopathy and Myosin Studies
- Cardiac Arrest and Resuscitation
- Acute Ischemic Stroke Management
- Health Systems, Economic Evaluations, Quality of Life
- Viral Infections and Immunology Research
- Electrostatic Discharge in Electronics
- Neuroscience and Neural Engineering
University Hospital of Bern
2018-2025
University of Bern
2018-2025
University of Basel
2011-2023
University Hospital of Basel
2014-2023
Medical University of Vienna
2022
Lucerne University of Applied Sciences and Arts
2019
Universität Hamburg
2017-2018
University Medical Center Hamburg-Eppendorf
2017-2018
Brazilian Network Information Center
2018
German Centre for Cardiovascular Research
2018
Vedran Velagic (Croatia), Sami Viskin (Israel)
We conducted a multicenter study to examine the diagnostic accuracy of new, sensitive cardiac troponin assays performed on blood samples obtained in emergency department from 718 consecutive patients who presented with symptoms suggestive acute myocardial infarction. Cardiac levels were determined blinded fashion use four (Abbott–Architect Troponin I, Roche High-Sensitive T, and Siemens I Ultra) standard assay (Roche T). The final diagnosis was adjudicated by two independent cardiologists.
The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy, and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical...
The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy, and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical...
High-sensitivity cardiac troponin (hs-cTn) assays seem to improve the early diagnosis of acute myocardial infarction (AMI), but it is unknown how best use them in clinical practice. Our objective was develop and validate an algorithm for rapid rule-out rule-in AMI.A prospective multicenter study enrolling 872 unselected patients with chest pain presenting emergency department. T (hs-cTnT) measured a blinded fashion at presentation after 1 hour. The final adjudicated by 2 independent...
Background— Current guidelines for the diagnosis of acute myocardial infarction (AMI), among other criteria, also require a rise and/or fall in cardiac troponin (cTn) levels. It is unknown whether absolute or relative changes cTn have higher diagnostic accuracy and should therefore be preferred. Methods Results— In prospective, observational, multicenter study, we analyzed (Δ) (Δ%) 836 patients presenting to emergency department with symptoms suggestive AMI. Blood samples determination...
The purpose of this study was to examine the incremental value copeptin for rapid rule out acute myocardial infarction (AMI). and reliable exclusion AMI is a major unmet clinical need. Copeptin, C-terminal part vasopressin prohormone, as marker endogenous stress may be useful in setting. In 487 consecutive patients presenting emergency department with symptoms suggestive AMI, we measured levels at presentation, using novel sandwich immunoluminometric assay blinded fashion. final diagnosis...
Perioperative myocardial injury (PMI) seems to be a contributor mortality after noncardiac surgery. Because the vast majority of PMIs are asymptomatic, PMI usually is missed in absence systematic screening. We performed prospective diagnostic study enrolling consecutive patients undergoing surgery who had planned postoperative stay ≥24 hours and were considered at increased cardiovascular risk. All received screening using serial measurements high-sensitivity cardiac troponin T clinical...
AimsTo examine the diagnostic accuracy of sensitive cardiac troponin (cTn) assays in elderly patients, since elevated levels with cTn were reported 20% patients without acute myocardial infarction (AMI).
Abstract Aims Pulsed field ablation (PFA) is a novel atrial fibrillation (AF) modality that has demonstrated preferential tissue ablation, including no oesophageal damage, in first-in-human clinical trials. In the MANIFEST-PF survey, we investigated ‘real world’ performance of only approved PFA catheter, acute effectiveness and safety—in particular, rare effects other unforeseen PFA-related complications. Methods results This retrospective survey included all 24 centres using pentaspline...
<h3>Background:</h3> We aimed to prospectively validate a novel 1-hour algorithm using high-sensitivity cardiac troponin T measurement for early rule-out and rule-in of acute myocardial infarction (MI). <h3>Methods:</h3> In multicentre study, we enrolled 1320 patients presenting the emergency department with suspected MI. The algorithm, incorporating baseline values as well absolute changes within first hour, was validated against final diagnosis. diagnosis then adjudicated by 2 independent...
It is unknown whether more sensitive cardiac troponin (cTn) assays maintain their clinical utility in patients with renal dysfunction. Moreover, optimal cutoff levels this vulnerable patient population have not previously been defined.In multicenter study, we examined the of 7 cTn (3 and 4 high-sensitivity assays) presenting symptoms suggestive acute myocardial infarction. Among 2813 unselected patients, 447 (16%) had dysfunction (defined as Modification Diet Renal Disease-estimated...
It is unknown whether cardiac troponin (cTn) I or cTnT the preferred biomarker in early diagnosis of acute myocardial infarction without ST segment elevation (NSTEMI).In a prospective multicentre study, we measured cTnI and using clinically available high-sensitivity assays (hs-cTnI Abbott hs-cTnT Roche) compared their diagnostic prognostic accuracies consecutive patients presenting to emergency department with chest pain. The final was adjudicated by two independent cardiologists all...
Background: High-sensitivity cardiac troponin assays enable myocardial infarction to be ruled out earlier, but the optimal approach is uncertain. We compared European Society of Cardiology rule-out pathway with a that incorporates lower concentrations risk stratify patients. Methods: Patients suspected acute coronary syndrome (n=1218) underwent high-sensitivity I measurement at presentation and 3 6 or 12 hours. (<99th centile hours if symptoms <6 hours) developed in High-STEACS study...
Pulsed field ablation is a novel nonthermal cardiac modality using ultra-rapid electrical pulses to cause cell death by mechanism of irreversible electroporation. Unlike the traditional energy sources, pulsed has demonstrated significant preferentiality myocardial tissue ablation, and thus avoids certain thermally mediated complications. However, its safety effectiveness remain unknown in usual clinical care.MANIFEST-PF (Multi-National Survey on Methods, Efficacy, Safety Post-Approval...
Pulsed field ablation (PFA) is a new, non-thermal modality for pulmonary vein (PV) isolation in patients with atrial fibrillation (AF). The multi-centre EUropean Real World Outcomes Field AblatiOn Patients Symptomatic AtRIAl Fibrillation (EU-PORIA) registry sought to determine the safety, efficacy, and learning curve characteristics pentaspline, multi-electrode PFA catheter.All-comer AF from seven high-volume centres were consecutively enrolled. Procedural follow-up data collected. Learning...
Abstract In the last three decades, ablation of atrial fibrillation (AF) has become an evidence-based safe and efficacious treatment for managing most common cardiac arrhythmia. 2007, first joint expert consensus document was issued, guiding healthcare professionals involved in catheter or surgical AF ablation. Mounting research evidence technological advances have resulted a rapidly changing landscape field ablation, thus stressing need regularly updated versions this partnership which were...
Abstract Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), which pre-clinical and early-stage clinical data are suggestive some degree preferentiality to myocardial tissue without damage adjacent structures. Here in MANIFEST-17K study we assessed safety PFA by studying post-approval use this modality. Of 116 centers performing with a pentaspline catheter, were received from 106 (91.4% participation) regarding 17,642 patients undergoing (mean...
Contact force has been used to titrate lesion formation for radiofrequency ablation. Pulsed field ablation (PFA) is a field-based technology which limited evidence on the impact of contact size available.Porcine hearts (n = 6) were perfused using modified Langendorff set-up. A prototype focal PFA catheter attached gauge was held perpendicular epicardium and lowered until made. recorded during each delivery. Matured lesions cross-sectioned, stained, dimensions measured.A total 82 evaluated...