A5088850609- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiovascular Syncope and Autonomic Disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- ECG Monitoring and Analysis
- Cardiovascular Effects of Exercise
- Non-Invasive Vital Sign Monitoring
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Systemic Lupus Erythematosus Research
- Heart Rate Variability and Autonomic Control
- Cardiac Health and Mental Health
- Vasculitis and related conditions
- Health Systems, Economic Evaluations, Quality of Life
- Congenital Heart Disease Studies
- Long-Term Effects of COVID-19
- Coronary Artery Anomalies
- Mechanical Circulatory Support Devices
- Atherosclerosis and Cardiovascular Diseases
- Hemodynamic Monitoring and Therapy
University Hospital Cologne
2016-2025
University of Cologne
2015-2025
Asklepios Klinik St. Georg
2025
Universitätsklinikum Gießen und Marburg
2025
Centrum für Integrierte Onkologie
2014-2023
Université de Caen Normandie
2017-2019
Centre Hospitalier Universitaire de Caen Normandie
2017-2019
Nutrition & Santé (Spain)
2019
Universität Hamburg
2005-2016
University Medical Center Hamburg-Eppendorf
2005-2016
Abstract Aims Pulsed field ablation (PFA) is a novel atrial fibrillation (AF) modality that has demonstrated preferential tissue ablation, including no oesophageal damage, in first-in-human clinical trials. In the MANIFEST-PF survey, we investigated ‘real world’ performance of only approved PFA catheter, acute effectiveness and safety—in particular, rare effects other unforeseen PFA-related complications. Methods results This retrospective survey included all 24 centres using pentaspline...
Pulsed field ablation is a novel nonthermal cardiac modality using ultra-rapid electrical pulses to cause cell death by mechanism of irreversible electroporation. Unlike the traditional energy sources, pulsed has demonstrated significant preferentiality myocardial tissue ablation, and thus avoids certain thermally mediated complications. However, its safety effectiveness remain unknown in usual clinical care.MANIFEST-PF (Multi-National Survey on Methods, Efficacy, Safety Post-Approval...
Catheter ablation for ventricular tachycardia (VT) reduces the recurrence of VT in patients with implantable cardioverter-defibrillators (ICDs). The appropriate timing and its effects on mortality heart failure progression remain a matter debate. In life-threatening arrhythmias necessitating ICD implantation, we compared outcomes preventive (undertaken before implantation to prevent shocks VT) deferred after 3 VT. BERLIN study (Preventive Ablation Ventricular Tachycardia Patients With...
Initial clinical studies of pulsed field ablation (PFA) to treat atrial fibrillation (AF) indicated a >90% durability rate pulmonary vein isolation (PVI). However, these were largely conducted in single centers and involved limited number operators. The electrophysiological findings outcomes patients undergoing repeat after an initial PF for AF are incompletely understood. In the MANIFEST-REDO study, we investigated who underwent due recurrence - or tachycardia (AT) following first-ever PVI...
In the meantime, catheter ablation is widely used for treatment of persistent atrial fibrillation (AF). There a paucity data about long-term outcomes. This study evaluates (1) 5-year single and multiple procedure success (2) prognostic factors arrhythmia recurrences after AF using stepwise approach aiming at termination. A total 549 patients with underwent de novo (2007-2009). 493 were included (Holter ECGs ≥ every 6 months). Mean follow-up was 59 ± 16 months 2.1 1.1 procedures per patient....
Catheter ablation (CA) for atrial fibrillation (AF) has emerged as a widespread first or second line treatment option. However, up to 45% of patients (pts) show recurrence AF within 12 month after CA. We present prospective multicenter registry data comparing characteristics pts with and without the year This study comprises all complete follow-up one CA (1-y-FU; n = 3679). During 1y-FU in 1687 (45.9%) occurred. The multivariate analysis revealed female sex type prior procedure predictors...
Background Identification and elimination of nonpulmonary vein targets may improve clinical outcomes in patients with persistent atrial fibrillation (AF). We report on the use a novel, noncontact imaging mapping system that uses ultrasound to reconstruct chamber anatomy measures timing density dipolar, ionic activation (ie, charge density) across myocardium guide ablation arrhythmias. Methods The prospective, nonrandomized UNCOVER AF trial (Utilizing Novel Dipole Density Capabilities...
TeleCheck-AF is a multicentre international project initiated to maintain care delivery for patients with atrial fibrillation (AF) during COVID-19 through teleconsultations supported by an on-demand photoplethysmography-based heart rate and rhythm monitoring app (FibriCheck®). We describe the characteristics, inclusion rates, experiences from participating centres according infrastructure as well characteristics recruited patients.Three surveys exploring centre (n = 25), 23), patient 826)...
Weight management seems to be beneficial for obese atrial fibrillation (AF) patients; however, randomized data are sparse. Thus, this study aimed investigate the influence of weight reduction on AF ablation outcomes.SORT-AF is an investigator-sponsored, prospective, randomized, multicentre, and clinical trial. Patients with symptomatic (paroxysmal or persistent) body mass index (BMI) 30-40 kg/m2 underwent were either weight-reduction (group 1) usual care 2), after sleep-apnoea-screening loop...
Abstract Aims Although guidelines for the management of atrial fibrillation (AF) are regularly published, many controversial issues remain, limiting their implementation. We aim to describe current clinical practice among European Heart Rhythm Association (EHRA) community according last guidelines. Methods and results A 30 multiple-choice questionnaire covering most topics related AF was distributed through EHRA Research Network, National Societies, social media between January February...
Abstract Ventricular tachycardia (VT), and its occurrence, is still one of the main reasons for sudden cardiac death and, therefore, increased mortality morbidity foremost in patients with structural heart [Kahle A-K, Jungen C, Alken F-A, Scherschel K, Willems S, Pürerfellner H et al. Management ventricular ischaemic cardiomyopathy: contemporary armamentarium. Europace 2022;24:538–51]. Catheter ablation has become a safe effective treatment option recurrent VT [Cronin EM, Bogun FM, Maury P,...
Mitral valve transcatheter edge-to-edge repair (M-TEER) has emerged as a viable therapy option in patients with severe mitral regurgitation and high surgical risk. Although atrial fibrillation is common among undergoing M-TEER, the optimal anticoagulatory treatment after intervention unknown. A single-center retrospective observational analysis was conducted using data from M-TEER registry at University Hospital Cologne collected 2019 untill 2021 including between November 2012 April 2019....
Reduced Fluoroscopy in PVI Using RN. Background: Recently, a nonmagnetic robotic navigation system (RN, Hansen‐Sensei™) has been introduced for remote catheter manipulation. Objective: To investigate the influence of RN combined with intuitive 3‐dimensional mapping on fluoroscopy exposure to operator and patient during pulmonary vein isolation (PVI) paroxysmal atrial fibrillation (PAF) prospective randomized trial. Methods: Sixty patients were randomly assigned undergo either using guided...
Pulmonary vein isolation (PVI) remains the cornerstone in treatment of atrial fibrillation (AF). PVI using cryoballoon (CB) technology has emerged as a standard procedure many centers. Recently, pulsed field ablation (PFA) been introduced and used to achieve PVI. First data show high acute favorable long-term outcomes. So far, comparing these new "single shot" devices are sparse. We sought compare procedural outcome for first time PFA users versus CB patients undergoing de novo Furthermore,...
Abstract Background The newly introduced nonthermal pulsed field ablation (PFA) is a promising technology to achieve fast pulmonary vein isolation (PVI) with high acute success rates and good safety features. However, previous studies have shown that very power short duration (VHPSD) also highly effective PVI potentially less arrhythmia recurrence compared conventional radiofrequency ablation. Data comparing PFA VHPSD‐PVI lacking. Objective This study procedural outcome data for PFA‐PVI in...
Abstract Aims Advanced ablation strategies are needed to treat ventricular tachycardia (VT) and premature complexes (PVC) refractory standard unipolar radiofrequency (Uni-RFA). Bipolar catheter (Bi-RFA) has emerged as a treatment option for VT PVC. Multicentre registry data on the use of Bi-RFA in setting PVC lacking. The aim this is determine its real-world safety, feasibility, efficacy patients with VT/PVC. Methods results Consecutive undergoing at 16 European centres recurring VT/PVC...
Within the TeleCheck-AF project, numerous centres in Europe used on-demand photoplethysmography (PPG) technology to remotely assess heart rate and rhythm conjunction with teleconsultations. Based on investigator experiences, we aimed develop an educational structured stepwise practical guide how interpret PPG signals introduce typical clinical scenarios was used.
Abstract Aims RECOVER AF evaluated the performance of whole-chamber non-contact charge-density mapping to guide ablation non-pulmonary vein (PV) targets in persistent atrial fibrillation (AF) patients following either a first or second failed procedure. Methods and results was prospective, non-randomized trial that enrolled scheduled for retreatment recurrent AF. The PVs were assessed re-isolated if necessary. maps used non-PV through elimination pathologic conduction patterns (PCPs)....