A5003665539- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Receptor Mechanisms and Signaling
- Health Systems, Economic Evaluations, Quality of Life
- Renin-Angiotensin System Studies
- Cardiovascular Function and Risk Factors
- Hemodynamic Monitoring and Therapy
- Thyroid Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Cardiovascular Syncope and Autonomic Disorders
- Neuropeptides and Animal Physiology
- Electrolyte and hormonal disorders
- Electrostatic Discharge in Electronics
- Microbial Inactivation Methods
- Heart Failure Treatment and Management
- Ion Transport and Channel Regulation
- High Altitude and Hypoxia
- Head and Neck Cancer Studies
- S100 Proteins and Annexins
- Central Venous Catheters and Hemodialysis
- Pharmacological Effects and Assays
Gentofte Hospital
2016-2025
Copenhagen University Hospital
2022-2024
University of Copenhagen
1981-2024
Glostrup Hospital
1981-2022
Aalborg University Hospital
2022
Brigham and Women's Hospital
2020
Rigshospitalet
2014-2020
Örebro University Hospital
1973-2014
Aarhus University Hospital
2014
Tampere University Hospital
2014
There are limited data comparing radiofrequency catheter ablation with antiarrhythmic drug therapy as first-line treatment in patients paroxysmal atrial fibrillation.We randomly assigned 294 fibrillation and no history of use to an initial strategy either (146 patients) or class IC III agents (148 patients). Follow-up included 7-day Holter-monitor recording at 3, 6, 12, 18, 24 months. Primary end points were the cumulative per-visit burden (i.e., percentage time on recordings). Analyses...
Abstract Aims Pulsed field ablation (PFA) is a novel atrial fibrillation (AF) modality that has demonstrated preferential tissue ablation, including no oesophageal damage, in first-in-human clinical trials. In the MANIFEST-PF survey, we investigated ‘real world’ performance of only approved PFA catheter, acute effectiveness and safety—in particular, rare effects other unforeseen PFA-related complications. Methods results This retrospective survey included all 24 centres using pentaspline...
Abstract Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), which pre-clinical and early-stage clinical data are suggestive some degree preferentiality to myocardial tissue without damage adjacent structures. Here in MANIFEST-17K study we assessed safety PFA by studying post-approval use this modality. Of 116 centers performing with a pentaspline catheter, were received from 106 (91.4% participation) regarding 17,642 patients undergoing (mean...
Patients undergoing catheter ablation for atrial fibrillation (AF) often experience recurrent arrhythmias within the first few months post-ablation. We aimed to investigate whether short-term use of amiodarone prevent early following radiofrequency AF could reduce later recurrence. In a two-centre, randomized, double-blind, placebo-controlled study, we randomized total 212 patients ablation. were stratified according type (paroxysmal/persistent) and history previous randomly assigned 8 weeks...
To investigate the long-term risk of thromboembolism and serious bleeding associated with oral anticoagulation (OAC) therapy beyond 3 months after radiofrequency ablation (RFA) atrial fibrillation (AF). Linking Danish administrative registries, 4050 patients undergoing first-time RFA (2000–11) were identified. Risk according to OAC analysed by incidence rates (presented per 100 person-years) Cox proportional-hazard models. The median age was 59.5 years (interquartile range, IQR: 52.8–65.2);...
During the last decade, ablation has increasingly been used in rhythm control management of patients with atrial fibrillation (AF). Over time, experience and techniques have improved indications for expanded. The purpose this study was to investigate whether recurrence rate AF following during decade.Through Danish nationwide registers, all first-time ablation, between 2005 2014 Denmark were identified. Recurrent after identified 1 year follow-up. A total 5425 undergoing included. While...
<h3>Objective</h3> The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation (MANTRA-PAF) trial compared radiofrequency catheter ablation (RFA) with antiarrhythmic drug therapy (AAD) as first-line treatment for paroxysmal atrial fibrillation (AF). Endpoint of was elimination electrical activity inside pulmonary veins. We present the results 5-year follow-up. <h3>Methods</h3> This pre-specified follow-up included assessment any AF and symptomatic burden...
[Figure: see text].
The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation (MANTRA-PAF) trial assessed the long-term efficacy of an initial strategy radiofrequency ablation (RFA) vs. antiarrhythmic drug therapy (AAD) as first-line treatment for patients with PAF. In this substudy, we evaluated effect these modalities on Health-Related Quality Life (HRQoL) and symptom burden at 12 24 months.During study period, 294 were enrolled MANTRA-PAF randomized to receive AAD (N =...
Despite improvement in treatment strategies of atrial fibrillation (AF), a considerable number patients still experience recurrence tachyarrhythmia (ATA) following catheter ablation (CA). This study aimed to investigate the prognostic value left (LA) deformation analysis large group undergoing CA for AF.This included 678 with AF. Echocardiography including two-dimensional speckle tracking echocardiography (2DSTE) was performed all prior CA. Logistic regression used assess association between...
Guidelines recommend prioritizing treatment with antiarrhythmic drugs before referral of patients atrial fibrillation to ablation, delaying a potential subsequent ablation. However, ablation may affect outcomes. We sought investigate the impact duration from diagnosis on risk recurrence and adverse events.
A sensitive radio‐immunoassay (RIA) for the measurement of human α‐atrial natriuretic peptide (ANP) in extracted plasma was developed and used a study possible effect posture on concentration ANP plasma. The least detectable quantity less than 2 pg per tube equivalent to 5 ml ‐1 In middle sensitivity range (approximately 50 tube), within‐assay between‐assay coefficients variation were 4.0 2.8%, respectively. recovery added prior extraction 95–101%. High pressure liquid chromatography (HPLC)...
Nielsen, Jens Cosedis; Johannessen, Arne; Raatikainen, Pekka; Hindricks, Gerhard; Walfridsson, Håkan; Kongstad, Ole; Pehrson, Steen; Englund, Anders; Hartikainen, Juha; Mortensen, Leif Spange; Hansen, Peter Steen Author Information
Abstract Aims Overweight is associated with increased risk of atrial fibrillation (AF), but the impact overweight and AF recurrence after ablation less clear. Despite this, an increasing number ablations are carried out in patients. We investigated body mass index (BMI) on rates ablation. Methods results Through Danish nationwide registers, all patients undergoing first-time between 2010 2018 were identified. Exposure interest was BMI. The primary outcome recurrent AF, defined from either...
The aim of this prospective substudy was to estimate the cost-effectiveness treating paroxysmal atrial fibrillation (AF) with radiofrequency catheter ablation (RFA) compared antiarrhythmic drugs (AADs) as first-line treatment.A decision-analytic Markov model, based on MANTRA-PAF (Medical Antiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation) study data, developed long-term effects and costs RFA AADs treatment. Positive clinical were found overall population, a...
Posterior wall isolation (PWI) added to pulmonary vein (PVI) is increasingly used despite limited evidence of clinical benefit. We investigated the feasibility, durability, and efficacy index-procedure PVI + PWI radio frequency ablation (RFA) in patients with persistent atrial fibrillation (PeAF).Twenty-four PeAF participated prospective PeAF-Box study underwent RFA wide area circumferential ablation, roof- inferior lines achieve at index procedure. Follow-up included monitoring by an...
Abstract Background Pulsed field ablation (PFA) is a novel method of cardiac where there insufficient knowledge on the durability and reconnection patterns after pulmonary vein isolation (PVI). The aim this study was to characterize electrophysiological findings at time repeat procedure in real-world atrial fibrillation (AF) patients. Methods Patients who underwent ( n =26) for symptomatic recurrent arrhythmias index first-time treatment with single-shot PFA PVI =266) from July 2021 June...
Abstract Aims Catheter ablation (CA) is a well-established treatment option for atrial fibrillation (AF), where sedation and analgesia are pivotal patient comfort lesion formation. The impact of anaesthesia type on AF recurrence rates remains uncertain. This study aimed to examine depending conscious (CS) vs. general (GA) during CA. Methods results Utilizing nationwide data from the Danish healthcare registries, we conducted this cohort involving adults (≥18 years) undergoing first-time CA...
The effect of 4 days intake a fat-enriched (76%) diet (F1 and F2 experiments) or carbohydrate-enriched (77%) (CH experiment) on circulating levels glucose, insulin, GH, PRL, thyroid hormones during prolonged exercise was studied in seven healthy males. After each the three periods, subjects ran treadmill at 70% individual maximal oxygen uptake. Atexhaustion, 10-min rest allowed, after which were encouraged to run while glucose CH insulin (F2 concentrations restored preexercise levels. fat...