Johann Bauersachs
A5016118935- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Nitric Oxide and Endothelin Effects
- Cardiac Fibrosis and Remodeling
- Cardiac pacing and defibrillation studies
- Hormonal Regulation and Hypertension
- Cardiac Imaging and Diagnostics
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Arrest and Resuscitation
- Cardiac Arrhythmias and Treatments
- Diabetes Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Congenital Heart Disease Studies
- Acute Myocardial Infarction Research
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Pulmonary Hypertension Research and Treatments
- Angiogenesis and VEGF in Cancer
- Cardiac electrophysiology and arrhythmias
- Peptidase Inhibition and Analysis
Medizinische Hochschule Hannover
2016-2025
German Cardiac Society
2020-2024
Clinical Research Institute
2024
Duke University Hospital
2024
University of Mississippi
2024
Duke Medical Center
2024
National Heart Centre Singapore
2024
British Heart Foundation
2024
National Heart Hospital
2024
Hannover Re (Germany)
2011-2023
A correction has been published: European Heart Journal, ehaa895, https://doi.org/10.1093/eurheartj/ehaa895
Guidelines summarize and evaluate available evidence with the aim of assisting health professionals in proposing best management strategies for an individual patient a given condition. their recommendations should facilitate decision making daily practice. However, final decisions concerning must be made by responsible professional(s) consultation caregiver as appropriate.
Guidelines •
The natural history, management, and outcome of takotsubo (stress) cardiomyopathy are incompletely understood.The International Takotsubo Registry, a consortium 26 centers in Europe the United States, was established to investigate clinical features, prognostic predictors, cardiomyopathy. Patients were compared with age- sex-matched patients who had an acute coronary syndrome.Of 1750 cardiomyopathy, 89.8% women (mean age, 66.8 years). Emotional triggers not as common physical (27.7% vs....
Poland), and Katja Zeppenfeld (
Background— Chronic heart failure is characterized by left ventricular remodeling and reactivation of a fetal gene program; the underlying mechanisms are only partly understood. Here we provide evidence that cardiac microRNAs, recently discovered key regulators expression, contribute to transcriptional changes observed in failure. Methods Results— Cardiac transcriptome analyses revealed striking similarities between failing human tissue. Using microRNA arrays, profound alterations expression...
The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy, and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical...
Pathological growth of cardiomyocytes (hypertrophy) is a major determinant for the development heart failure, one leading medical causes mortality worldwide. Here we show that microRNA (miRNA)-212/132 family regulates cardiac hypertrophy and autophagy in cardiomyocytes. Hypertrophic stimuli upregulate cardiomyocyte expression miR-212 miR-132, which are both necessary sufficient to drive hypertrophic MiR-212/132 null mice protected from pressure-overload-induced whereas cardiomyocyte-specific...
The ESC/EACTS Guidelines represent the views of ESC and EACTS were produced after careful consideration scientific medical knowledge evidence available at time their publication.The are not responsible in event any contradiction, discrepancy and/ or ambiguity between other official recommendations guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals encouraged take fully into account when exercising...
Background The contribution of the endothelium-derived hyperpolarizing factor (EDHF), proposed to be a cytochrome P450–derived metabolite arachidonic acid, endothelium-dependent dilatation under physiological conditions has yet established, because its effect can detected only after inhibition NO synthase and cyclooxygenase. possibility that exerts feedback on EDHF formation was studied in isolated perfused arterial segments. Methods Results Under combined blockade cyclooxygenase,...
1. In addition to nitric oxide (NO) and prostacyclin (PGI2) an as yet unidentified endothelium‐derived hyperpolarizing factor (EDHF) contributes the dilator effect of bradykinin in different vascular beds. We have investigated nature mechanism action this freshly isolated bovine porcine coronary artery segments which were preconstricted with thromboxane mimetic U46619 (9,11‐dideoxy‐11 alpha, 9 alpha‐epoxymethano‐prostaglandin F2 10‐30 nM). 2. The concentration‐response curve was...
The role of adaptive immunity, especially CD4(+) T-helper cells, has not yet been systematically investigated in wound healing and remodeling after myocardial infarction (MI). Therefore, we studied whether T cells become activated influence experimental MI mice.When compared sham versus wild-type (WT) mice, T-cell receptor-dependent activation both conventional Foxp3(-) regulatory Foxp3(+) could be demonstrated heart-draining lymph nodes within the first week MI. Concomitantly, found...
Uncoupling of the endothelial nitric oxide synthase (eNOS) resulting in superoxide anion (O(2)(-)) formation instead (NO) causes diabetic dysfunction. eNOS regulates mobilization and function progenitor cells (EPCs), key regulators vascular repair. We postulate a role uncoupling for reduced number EPC diabetes. levels patients were significantly compared with those control subjects. EPCs from produced excessive O(2)(-) showed impaired migratory capacity nondiabetic NOS inhibition...
Background— Myocardial infarction leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after has been identified as a critical event in this process, although the underlying mechanisms angiogenesis are mechanistically not well understood. Methods Results— Here, we show that small noncoding RNA microRNA-24 (miR-24) is enriched endothelial cells considerably upregulated ischemia. MiR-24 induces cell apoptosis, abolishes network formation on...