Tommaso Simoncini
A5004083793- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Pelvic floor disorders treatments
- Phytoestrogen effects and research
- Endometriosis Research and Treatment
- Ovarian function and disorders
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Endometrial and Cervical Cancer Treatments
- Anorectal Disease Treatments and Outcomes
- Cancer Risks and Factors
- Uterine Myomas and Treatments
- Reproductive Biology and Fertility
- Gynecological conditions and treatments
- Nitric Oxide and Endothelin Effects
- Urinary Bladder and Prostate Research
- Birth, Development, and Health
- Pelvic and Acetabular Injuries
- Cytokine Signaling Pathways and Interactions
- Pregnancy and preeclampsia studies
- Surgical Simulation and Training
- Growth Hormone and Insulin-like Growth Factors
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Hypothalamic control of reproductive hormones
University of Pisa
2016-2025
Azienda Ospedaliera Universitaria Pisana
2012-2024
International Federation of Gynaecology and Obstetrics
2023
John Wiley & Sons (United States)
2023
Institut de Virologie
2021-2022
Ospedale Cisanello
2021
Ospedale Santa Chiara
2021
Cornwall Council
2021
Aristotle University of Thessaloniki
2017
Carol Davila University of Medicine and Pharmacy
2017
Background — The products of nonenzymatic glycation and oxidation proteins, the advanced end (AGEs), form under diverse circumstances such as aging, diabetes, kidney failure. Recent studies suggested that AGEs may in inflamed foci, driven by or myeloperoxidase pathway. A principal means which alter cellular properties is through interaction with their signal-transduction receptor RAGE. We tested hypothesis RAGE on endothelial cells enhances vascular activation. Methods Results AGEs, RAGE,...
The binding of thyroid hormone to the receptor (TR) mediates important physiological effects. However, transcriptional effects TR mediated by response element (TRE) cannot explain many actions hormone. We postulate that can initiate rapid, non-TRE-mediated in cardiovascular system through cross-coupling phosphatidylinositol 3-kinase (PI3-kinase)/protein kinase Akt pathway. In vascular endothelial cells, predominant isoform is TRalpha1. Treatment cells with L-3,5,3'-triiodothyronine (T3)...
The objective of this work is to assess the 5-year outcomes patients undergoing conization for high-grade cervical lesions that simultaneously present as risk factors in persistence HPV infection and positivity surgical resection margins. This a retrospective study evaluating lesions. All included had both positive margins experienced at 6 months. Associations were evaluated with Cox proportional hazard regression summarized using ratio (HR). charts 2966 reviewed. Among whole population, 163...
Cerebral blood flow is regulated by endothelium-derived nitric oxide (NO), and endothelial NO synthase–deficient (eNOS-deficient; eNOS–/–) mice develop larger cerebral infarctions following middle artery (MCA) occlusion. We report that disruption of Rho-mediated actin cytoskeleton leads to the upregulation eNOS expression reduces severity ischemia MCA Mice treated with Rho inhibitor Clostridium botulinum C3 transferase (10 μg/d) or disrupter cytochalasin D (1 mg/kg) showed a two- fourfold...
Many cellular responses to corticosteroids involve the transcriptional modulation of target genes by glucocorticoid receptor (GR). A rapid, non-nuclear effect GR was found mediate neuroprotection. High-dose (20 mg/kg intraperitoneally), given within 2 hours transient cerebral ischemia, acutely increased endothelial nitric oxide synthase (eNOS) activity, augmented regional blood flow (CBF) 40% 50%, and reduced infarct size 32%. These neuroprotective effects were abolished antagonist RU486...
Sex steroids control cell movement and tissue organization; however, little is known of the involved mechanisms. This report describes ongoing dynamic regulation by estrogen actin cytoskeleton in human vascular endothelial cells that depends on rapid activation actin-regulatory protein moesin. Moesin triggered interaction C-terminal portion membrane receptor α with G Gα13, leading to small GTPase RhoA downstream effector Rho-associated kinase. The resulting phosphorylation moesin Thr558...
Objectives: To evaluate the long-term efficacy of a second generation vaginal laser treatment, erbium laser, as non-ablative photothermal therapy for management genitourinary syndrome menopause.Methods: The study was performed using an crystal yttrium-aluminum-garnet (XS Fotona Smooth™, Fotona, Ljubljana, Slovenia) with wavelength 2940 nm. Postmenopausal women (n = 205) were treated three applications at 30-day intervals. Symptoms assessed before and after treatment throughout 24 months,...
ObjectiveThe aim of the study is to evaluate how individual and couple's sexuality had changed during COVID-19 pandemic-related quarantine.MethodsA quantitative correlational research was conducted, using a web-based survey.ResultsAbout 1576 participants were involved: 1018 women (64.6%) 558 men (35.4%). A significant decline in mean well-being scores quarantine, compared before, reported. positive correlation between number sexual intercourse (SI) before quarantine found. The SI decreased...
Background: Cervical dysplasia persistence/recurrence has a great impact on women's health and quality of life. In this study, we investigated whether prognostic nomogram may improve risk assessment after primary conization. Methods: This is retrospective multi-institutional study based charts consecutive patients undergoing conization between 1 January 2010 31 December 2014. A assessing the importance different variables was built. cohort treated 2015 30 June 2016 used to validate nomogram....