A5074577188- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Nuclear reactor physics and engineering
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- MicroRNA in disease regulation
- Nuclear Materials and Properties
- Cancer-related molecular mechanisms research
- Nuclear Physics and Applications
- Circular RNAs in diseases
- Endometriosis Research and Treatment
- Nuclear and radioactivity studies
- Nuclear Engineering Thermal-Hydraulics
- Graphite, nuclear technology, radiation studies
- Pregnancy and preeclampsia studies
- COVID-19 and healthcare impacts
- Intraperitoneal and Appendiceal Malignancies
- Prenatal Screening and Diagnostics
- Lymphoma Diagnosis and Treatment
- FOXO transcription factor regulation
- Assisted Reproductive Technology and Twin Pregnancy
- Cardiovascular Issues in Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- COVID-19 Impact on Reproduction
- Colorectal and Anal Carcinomas
University of Brescia
2015-2024
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2011-2024
University of Verona
2016-2023
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
GlaxoSmithKline (India)
2022
Clovis Oncology (United Kingdom)
2022
Collaborative Group (United States)
2022
Organisation de Coopération et de Développement Economiques
1991-2021
Brescia University
1998-2021
University of Birmingham
2020-2021
BACKGROUND Invasive vulvar carcinoma is a rare disease with an incidence rate of 3–5% all female genital neoplasms. The current study discusses the limited number articles in literature regarding patterns recurrence as well clinical outcome patients recurrent based on consistent and consecutive series cases. METHODS A common chart focusing was used five Italian gynecologic institutions uniform criteria surgical nomenclature, pathologic variables, sites recurrence. Between 1980–1994, 502...
Neoadjuvant chemotherapy may represent an alternative to irradiation in locally advanced squamous cell cervical cancer. Aims of this study were compare a three-drug (paclitaxel, ifosfamide, and cisplatin [TIP]) with two-drug (ifosfamide [IP]) regimen assess the prognostic value pathologic response on survival.Patients (n = 219) randomly assigned ifosfamide 5 g/m(2) during 24 hours plus 75 mg/m(2), or paclitaxel 175 mg/m(2) every 3 weeks for three courses.Grades 4 neutropenia, anemia,...
Abstract Background: The aim of this work was to analyze the diagnostic and prognostic value serum human epididymis protein 4 (HE4) Risk for Ovarian Malignancy Algorithm (ROMA) in epithelial ovarian cancer (EOC). Methods: Preoperative samples 419 women (140 healthy controls, 131 benign cysts, 34 endometriosis, 114 EOC) were tested CA125 HE4 using fully automated methods (Abbott ARCHITECT) validated cutoff values. Results: For discrimination masses from EOC, premenopausal women, sensitivity...
Eleven previously untreated women with recurrent and/or metastatic granulosa cell tumor of the ovary were treated cisplatin, vinblastine, and bleomycin in combination. All six pathological complete responders but one are alive free disease at a median follow-up time 14 months from start treatment. Of three partial responders, two died drug-related toxicity while one, only microscopic second-look laparotomy, is without evidence 34 months. Hematologic nonhematologic severe. These promising...
The international OECD/NRC BWR Full-size Fine-Mesh Bundle Tests (BFBT) benchmark, based on the NUPEC database, encourages advancement in sub-channel analysis of two-phase flow rod bundles, which has great relevance with regard to nuclear reactor safety margin evaluation. This benchmark specification is being designed so that it can systematically assess and compare participants' numerical models for prediction detailed void distributions critical powers full-scale experimental data a...
The purpose of this study was to assess the diagnostic and prognostic impact preoperative serum determination human epididymis protein 4 (sHE4), investigate its potential correlation with clinicopathological features survival endpoints in endometrial cancer patients.Preoperative samples from 193 patients 125 women normal endometrium were measured for sHE4 CA125 (sCA125) concentrations by quantitative chemiluminescent microparticle immunoassays on automated Architect instrument.sHE4...
Purpose: Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs and is characterized by good prognosis with fewer than 20% patients relapsing. As it occurs less frequently advanced-stage EOC, its molecular features have not been thoroughly investigated. We demonstrated that in stage EOC miR-200c-3p can predict patients' outcome. In the present study, we analyzed expression long non-coding RNAs (lncRNA) to enable potential definition a transcriptional signature prognostic...
Epithelial ovarian cancer (EOC) is a spectrum of different diseases, which makes their treatment challenge. Forkhead box M1 (FOXM1) an oncogene aberrantly expressed in many solid cancers including serous EOC, but its role non-serous EOCs remains undefined. We examined FOXM1 expression and correlation to prognosis across the three major EOC subtypes, tumorigenesis chemo-resistance vitro.Gene signatures were generated by microarray for 14 clear-cell 26 endometrioid EOCs, 15 normal endometrium...
This is a retrospective study of patients treated for early-stage cervical cancer to identify pathologic risk factors associated with ovarian metastases and, therefore, establish when preservation can be performed without increasing the relapse in order improve quality life premenopausal patients. Between 1982 and 2004, 1965 FIGO stage IA2-IB-IIA squamous cell carcinoma nonsquamous histology types were surgically treated; 1695 (86%) underwent primary radical hysterectomy, bilateral...