A5086086408- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Cervical Cancer and HPV Research
- Radiomics and Machine Learning in Medical Imaging
- Microbial Inactivation Methods
- Sarcoma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Gynecological conditions and treatments
- Colorectal and Anal Carcinomas
- Reproductive System and Pregnancy
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- BRCA gene mutations in cancer
- Toxin Mechanisms and Immunotoxins
- Cancer Risks and Factors
- Circular RNAs in diseases
- Reproductive Biology and Fertility
- Management of metastatic bone disease
- Appendicitis Diagnosis and Management
- Ovarian function and disorders
- Polyomavirus and related diseases
- MicroRNA in disease regulation
Azienda USL di Bologna
2020-2025
University of Bologna
2016-2025
Iuliu Hațieganu University of Medicine and Pharmacy
2025
Policlinico S.Orsola-Malpighi
2015-2024
Agenzia Sanitaria e Sociale Regionale
2023
Regione Emilia-Romagna
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2023
Essen University Hospital
2022
Memorial Sloan Kettering Cancer Center
2022
Gynecologic Oncology Group
2020-2022
The objective of this work is to assess the 5-year outcomes patients undergoing conization for high-grade cervical lesions that simultaneously present as risk factors in persistence HPV infection and positivity surgical resection margins. This a retrospective study evaluating lesions. All included had both positive margins experienced at 6 months. Associations were evaluated with Cox proportional hazard regression summarized using ratio (HR). charts 2966 reviewed. Among whole population, 163...
This study aimed to describe 2 types of endometriosis-associated ovarian cancer: those with transitional elements (atypical endometriosis and borderline tumors) termed endometriosis-correlated or incidental benign vs cancer cases not associated endometriosis. was a prospective, observational, monocentric conducted from November 2021 December 2023. Patients eligible for surgery were enrolled classified into carcinoma, endometriosis-incidental carcinoma without groups based on the presence...
Abstract Objectives To compare the accuracy of transvaginal sonography (TVS) and magnetic resonance imaging (MRI) in preoperative staging endometrial carcinoma. Methods This was a prospective study which 74 women consecutively diagnosed with carcinoma were examined using TVS by physicians trained gynecological MRI radiologists special interest gynecology. All patients underwent surgical–pathological after removal uterus, adnexa pelvic lymph nodes. Sensitivity, specificity, positive negative...
In Brief OBJECTIVE: To investigate the risk of vaginal cuff dehiscence after different routes hysterectomy and methods closure. METHODS: A multi-institutional analysis 12,398 patients who underwent for both benign malignant disease between 1994 2008 was performed. We analyzed how approaches to suture may influence development dehiscence. RESULTS: Women had total laparoscopic (n=3,573), abdominal (n=4,291), (n=4,534) hysterectomies experienced 23 (0.64%), 9 (0.2%), 6 (0.13%) cases dehiscence,...
The aim of this study was to help with the process selecting patients advanced ovarian cancer undergo cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy (HIPEC) by analyzing outcome data at distinct clinical time points reflecting natural history disease.In a retrospective Italian multicenter investigating who underwent CRS plus HIPEC between 1998 and 2014, we analyzed for consecutive eight treatment points: primary debulking (PDS); interval after partial response, no...
Background: Cervical dysplasia persistence/recurrence has a great impact on women's health and quality of life. In this study, we investigated whether prognostic nomogram may improve risk assessment after primary conization. Methods: This is retrospective multi-institutional study based charts consecutive patients undergoing conization between 1 January 2010 31 December 2014. A assessing the importance different variables was built. cohort treated 2015 30 June 2016 used to validate nomogram....
PURPOSE To investigate whether the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to secondary cytoreductive surgery (SCS) without neoadjuvant has a benefit on progression-free survival (PFS), as opposed SCS alone in patients with platinum-sensitive recurrent epithelial ovarian cancer (platinum-free interval, >6 months). METHODS This was multicenter randomized phase III study. Random assignment performed at time cases residual tumor ≤0.25 cm. HIPEC cisplatin (CDDP) 75 mg/m...
Background/Objectives: The aim of this study was the early identification endometriosis-associated ovarian cancer (EAOC) versus non-endometriosis associated (NEOC) or non-cancerous tissues using pre-surgery contrast-enhanced-Computed Tomography (CE-CT) images in patients undergoing surgery for suspected (OC). Methods: A prospective trial designed to enroll OC. Volumes interest (VOIs) were semiautomatically segmented on CE-CT and classified according histopathological results. entire dataset...
Our study purpose was to evaluate morbidity and postoperative mortality in patients who underwent pelvic exenteration (PE) for primary or recurrent gynecological malignancies.We identified 230 PE, referred the oncology units of 4 institutions: Charitè University Berlin, Friedrich-Schiller Jena, S. Orsola-Malpighi Bologna, Catholic Rome Campobasso.The median age 55 years. The tumor site cervix 177 patients, endometrium 28 vulva 16 vagina 9 patients. Sixty-eight anterior, 31 posterior, 131...
Objective: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been recently reported with favorable oncological outcomes as treatment of advanced epithelial ovarian cancer (EOC).The aim this study was to demonstrate the feasibility CRS+HIPEC cisplatin paclitaxel for EOC.Methods: This is a prospective observational 54 patients, from April 2007 October 2013, primary or recurrent peritoneal carcinomatosis due EOC.The mean age 54.51±9.34.Thirty patients (59%)...
Evaluate the survival of patients who underwent pelvic exenteration (PE) with curative intent for primary persistent or recurrent cervical cancer.We retrospectively investigated 167 consecutive patients, referred to gynecological oncology units 4 centers in Germany Italy, PE. Data regarding surgery, histology, and oncologic outcomes were collected statistically evaluated. Survival was determined from day until last follow-up death.The median age 51 years. Twenty-seven (16.2%) PE owing...
Uterine Leiomyosarcoma (uLMS) is by far the most common type of uterine sarcoma, characterized an aggressive clinical course, a heterogeneous genetic profile and very scarce response to cytotoxic chemotherapy. The make-up uLMS area active study that could provide essential cues for development new therapeutic approaches. A total 216 patients with from cBioPortal AACR-GENIE databases were included in study. vast majority (81%) carried at least one mutation either TP53, RB1, ATRX or PTEN....