Francesco Raspagliesi
A5000568505- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Sarcoma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Renal cell carcinoma treatment
- Genital Health and Disease
- Gynecological conditions and treatments
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 and healthcare impacts
- Cancer Genomics and Diagnostics
- Reproductive Biology and Fertility
- Cancer Risks and Factors
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
Fondazione IRCCS Istituto Nazionale dei Tumori
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
Clinica Universidad de Navarra
2024
University of Milan
2002-2024
Agostino Gemelli University Polyclinic
2024
European Institute of Oncology
2024
Sapienza University of Rome
2023
Innsbruck Medical University
2023
Universität Innsbruck
2023
Saitama Medical University
2022
Pelvic lymph nodes are the most common site of extrauterine tumor spread in early-stage endometrial cancer, but clinical impact lymphadenectomy has not been addressed randomized studies. We conducted a trial to determine whether addition pelvic systematic standard hysterectomy with bilateral salpingo-oophorectomy improves overall and disease-free survival. From October 1, 1996, through March 31, 2006, 514 eligible patients preoperative International Federation Gynecology Obstetrics stage I...
Dostarlimab is an immune-checkpoint inhibitor that targets the programmed cell death 1 receptor. The combination of chemotherapy and immunotherapy may have synergistic effects in treatment endometrial cancer.We conducted a phase 3, global, double-blind, randomized, placebo-controlled trial. Eligible patients with primary advanced stage III or IV first recurrent cancer were randomly assigned 1:1 ratio to receive either dostarlimab (500 mg) placebo, plus carboplatin (area under...
Systematic pelvic and paraaortic lymphadenectomy has been widely used in the surgical treatment of patients with advanced ovarian cancer, although supporting evidence from randomized clinical trials limited.
Background Despite significant advances in the screening, detection, and treatment of preinvasive cervical lesions, invasive cancer is fifth most common European women. There are large disparities Europe worldwide incidence, management, mortality cancer. Objective The Society Gynaecological Oncology (ESGO), for Radiotherapy (ESTRO), Pathology (ESP) jointly develop clinically relevant evidence-based guidelines order to improve quality care women with across worldwide. Methods ESGO/ESTRO/ESP...
Minimally invasive surgery in cervical cancer has demonstrated recent publications worse outcomes than open surgery. The primary objective of the SUCCOR study, a European, multicenter, retrospective, observational cohort study was to evaluate disease-free survival patients with stage IB1 (FIGO 2009) undergoing vs minimally radical hysterectomy. As secondary objective, we aimed investigate association between protective surgical maneuvers and risk relapse. We obtained data from 1272 that...
6000 Background: The role of secondary cytoreductive surgery in recurrent ovarian cancer (ROC) has been under debate for decades. A recent trial unselected patients (pts) failed to show an OS benefit. Methods: Pts with ROC and 1st relapse after 6+ months (mos) platinum-free interval (TFIp) were eligible if they presented a positive AGO-score (PS ECOG 0, ascites ≤500 ml, complete resection at initial surgery) prospectively randomized second-line chemotherapy alone vs. followed by the same...
To evaluate how the duration of human papillomavirus (HPV) persistence influences risk developing recurrent high-grade cervical dysplasia (CIN2+).Data patients with persistent HPV infection (at least at 6 months) after primary conization were extracted from a multi-institutional Italian database, retrospectively. Kaplan-Meier and Cox proportional hazards models used to associations between 5-year CIN2+.Overall, 545 met inclusion criteria. Positive margins detected in 160 (29.3%) patients....
The objective of this work is to assess the 5-year outcomes patients undergoing conization for high-grade cervical lesions that simultaneously present as risk factors in persistence HPV infection and positivity surgical resection margins. This a retrospective study evaluating lesions. All included had both positive margins experienced at 6 months. Associations were evaluated with Cox proportional hazard regression summarized using ratio (HR). charts 2966 reviewed. Among whole population, 163...
Human papillomavirus (HPV) is the primary cause of cervical dysplasia and cancer. Attempts are needed to better categorize patients with HPV in order provide useful information for prognosticating appropriately tailoring surveillance.
Objective: To date, no data supports the execution of vaccination after hysterectomy for high-grade cervical intraepithelial neoplasia (CIN2+) and early-stage cancer. We aim to evaluate potential effect Methods: This is a multi-center retrospective study evaluating women who develop lower genital tract dysplasia (including anal, vulvar vaginal intra-epithelial neoplasia) having CIN2+ FIGO stage IA1- IB1 Results: Overall, charts 77 patients developed were collected. The population included 62...
Endometriosis is a benign, chronic, inflammatory condition affecting up to 10 % of women and characterised by the presence glands stroma tissue outside uterus. Epidemiological clinical studies demonstrate consistent association between endometriosis infertility. However, this relationship far be clearly understood several mechanisms are involved. Available data show that patients with have an increased estimated risk infertility two four times compared general population. On other hand,...