A5065557495- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Global Cancer Incidence and Screening
- Global Maternal and Child Health
- Uterine Myomas and Treatments
- Cancer Risks and Factors
- Hepatitis B Virus Studies
- Vaccine Coverage and Hesitancy
- Maternal and fetal healthcare
- Intraperitoneal and Appendiceal Malignancies
- HIV/AIDS Impact and Responses
- Maternal and Perinatal Health Interventions
- Colorectal and Anal Carcinomas
- HIV/AIDS Research and Interventions
- Ovarian function and disorders
- AI in cancer detection
- Adolescent Sexual and Reproductive Health
- Reproductive Biology and Fertility
- Economic and Financial Impacts of Cancer
- Urological Disorders and Treatments
- Tissue Engineering and Regenerative Medicine
- Hepatitis C virus research
- Health Systems, Economic Evaluations, Quality of Life
Leiden University Medical Center
2013-2025
Leiden University
2010-2025
Clinica Universidad de Navarra
2024
Ministry of Health
2011-2013
Nederlandse Vereniging voor Tropische Geneeskunde
2013
Cal Humanities
2013
Ghent University
2000
Minimally invasive surgery in cervical cancer has demonstrated recent publications worse outcomes than open surgery. The primary objective of the SUCCOR study, a European, multicenter, retrospective, observational cohort study was to evaluate disease-free survival patients with stage IB1 (FIGO 2009) undergoing vs minimally radical hysterectomy. As secondary objective, we aimed investigate association between protective surgical maneuvers and risk relapse. We obtained data from 1272 that...
Objective To evaluate disease-free survival of cervical conization prior to radical hysterectomy in patients with stage IB1 cancer (International Federation Gynecology and Obstetrics (FIGO) 2009). Methods A multicenter retrospective observational cohort study was conducted including from the Surgery Cervical Cancer Comparing Different Surgical Aproaches Stage (SUCCOR) database FIGO 2009 carcinoma treated between January 1, 2013, December 31, 2014. We used propensity score matching minimize...
Introduction Evidence-based preventive strategies for cervical cancer in low-resource setting have been developed, but implementation is challenged, and uptake remains low. Women girls experience social economic barriers to attend screening human papillomavirus (HPV) vaccination programs. Male support has proven successful of other reproductive healthcare services. This qualitative study with focus groups aimed understand the perspectives males on HPV Western-Uganda knowledge could be...
Introduction WHO proposes a set of organ-failure based criteria for maternal near miss. Our objective was to evaluate what implementation these would mean the analysis cohort 386 women in Thyolo District, Malawi, who sustained severe acute morbidity according disease-based criteria. Methods and Findings A Maternal Near Miss (MNM) Tool, created compare disease-, intervention- miss, completed each woman, on review all available medical records. Using developed local setting, 341 (88%)...
<h3>Objective</h3> The aim of this study was to compare the incidence intra-operative and post-operative complications in open minimally invasive radical hysterectomy for patients with early-stage cervical cancer. <h3>Methods</h3> Data were collected from SUCCOR database 1272 stage IB1 cancer (International Federation Gynecology Obstetrics (FIGO), 2009) who underwent Europe between January 2013 December 2014. We reviewed duration surgeries, estimated blood loss, length hospital stay,...
Abstract Objectives Imaging is increasingly used to assess lymph node involvement in clinically early-stage cervical cancer. This retrospective study aimed evaluate the diagnostic accuracy of MRI, CT, and [ 18 F]FDG-PET-CT. Methods Women with International Federation Gynaecology Obstetrics (FIGO) 2009 stage IA2-IIA cancer pretreatment imaging between 2017 were selected from Netherlands Cancer Registry. Patient-based region-based (i.e. pelvic common iliac) nodal status was extracted radiology...
The aim of this study was to assess the superiority ICG-99mTc-nanocolloid for intraoperative visual detection sentinel lymph nodes (SLNs) in vulvar squamous cell carcinoma (VSCC) patients compared standard SLN using 99mTc-nanocolloid with blue dye.In multicenter, randomized controlled trial, VSCC underwent either procedure or hybrid tracer ICG-99mTc-nanocolloid. primary endpoint percentage fluorescent SLNs SLNs. Secondary endpoints were successful procedures, surgical outcomes and...
Detection and resection of all malignant lesions is pivotal in staging cytoreductive surgery (CRS) endometrial cancer (EC). Intraoperative EC detection could be enhanced using OTL-38, a fluorescent-labelled folate receptor-α (FRα) targeted imaging agent. The objectives this study were to investigate which subgroups high-risk patients express FRα assess feasibility intraoperative OTL-38.FRα expression on TMA was significantly correlated with tumor type (p < 0.01). Eighty-two percent serous...
To assess the feasibility, safety, oncological, and obstetric outcomes in patients with cervical tumors >2 cm treated neoadjuvant chemotherapy preparation for abdominal radical trachelectomy.A retrospective analysis of cancer (up to 6 cm) was conducted who were selected receive before trachelectomy. Surgical clinical examined relation radiological pathological results. In addition, described. The Mann-Whitney U test Fisher's exact performed compare findings between successful unsuccessful...
Treatment strategies for bulky lymph nodes in patients with locally advanced cervical cancer scheduled definitive chemoradiation include nodal boosting radiotherapy, surgical debulking, or both. The aim of this retrospective cohort study was to compare survival and toxicity receiving these treatments them a group that received neither form treatment.
Objective Treatment of cervical cancer patients in Uganda is hampered by late diagnosis due to the unavailability timely screening and limited availability advanced care. This study evaluated clinical presentation management presenting at Cancer Institute (UCI) Kampala, tertiary oncology facility with access radiotherapy reflected on daily practice identify priority areas for improving care Uganda. Patients methods We retrospectively analyzed medical records all UCI between January 2017...
Cervical cancer is the second most prominent among women in Bangladesh, which mainly caused by persistent infection with high-risk human papillomavirus (hrHPV). This study aims to evaluate impact of hrHPV prevalence on cost-effectiveness screening self-sampling testing versus visual inspection acetic acid (VIA) for cervical low- and middle-income countries Bangladesh as an example. A micro-simulation Markov model was developed from a health system perspective followed VIA primary method...
Background/Objectives: Fertility-sparing surgery (FSS) is a standard practice for managing early stage cervical cancer, yet significant variation exists in clinical approaches worldwide. Our objective was to ascertain current practices and preferences cerclage use among expert centers globally regarding FSS patients with cancer. Methods: We conducted cross-sectional survey from May July 2023 involving identified through their scientific contributions participation international workgroups...
Visual inspection with acetic acid is limited by subjectivity and a lack of skilled human resource. A decision support system based on artificial intelligence could address these limitations. We conducted diagnostic study to assess the performance using visual under magnification healthcare workers, experts, an algorithm.A total 22 9 gynecologists/experts in acid, algorithm assessed set 83 images from existing datasets expert consensus as reference. Their was determined analyzing...
Introduction In Ethiopia there is an extensive unmet need for palliative care, while the burden of non-communicable diseases and cancer increasing. This study aimed to explore care needs preferences patients, their caregivers, perspective stakeholders on service provision in programs women, mostly affected by cervical breast cancer. Methods A rapid program evaluation using a qualitative approach was conducted three home-based Addis Ababa Yirgalem town, Ethiopia. Female patients enrolled...
Abstract Objective Standard surgical treatment of advanced-stage ovarian carcinoma with electrosurgery cannot always result in complete cytoreductive surgery (CRS), especially when many small metastases are found on the mesentery and intestinal surface. We investigated whether adjuvant use a neutral argon plasma device can help increase cytoreduction rate. Patients Methods 327 patients FIGO stage IIIB–IV epithelial cancer (EOC) who underwent primary or interval CRS were randomized to either...
The most important goal for survival benefit of advanced stage ovarian cancer is to surgically remove all visible tumour, because complete cytoreductive surgery (CCS) has been shown be associated with prolonged survival. In a remarkable number women, CCS very challenging. Especially in women many small metastases on the peritoneum and intestinal surface, conventional electrosurgery not able "complete" removing safely tumour. this randomized controlled trail (RCT) we investigate whether use...
Abstract Background High-risk human papillomavirus (hrHPV) testing has been recommended by the World Health Organization as primary screening test in cervical programs. The option of self-sampling for this method can potentially increase women’s participation. Designing programs to implement among underscreened populations will require contextualized evidence. Methods PREvention and SCReening Innovation Project Toward Elimination Cervical Cancer (PRESCRIP-TEC) use a multi-method approach...
To identify factors contributing to the high incidence of facility-based obstetric hemorrhage in Thyolo District, Malawi, according local health workers.Three focus group discussions among 29 workers, including nurse-midwives and non-physician clinicians ('medical assistants' 'clinical officers').Factors mentioned by participants were categorized into four major areas: (1) limited availability basic supplies, (2) lack human resources, (3) inadequate clinical skills available workers (4)...