A5027346107- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Maternal and fetal healthcare
- Endometrial and Cervical Cancer Treatments
- Intraperitoneal and Appendiceal Malignancies
- Maternal and Perinatal Health Interventions
- Uterine Myomas and Treatments
- Pregnancy and preeclampsia studies
- Ectopic Pregnancy Diagnosis and Management
- Colorectal and Anal Carcinomas
- BRCA gene mutations in cancer
- Renal cell carcinoma treatment
- Gestational Trophoblastic Disease Studies
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Cancer Genomics and Diagnostics
- Cancer survivorship and care
- Pelvic floor disorders treatments
- Endometriosis Research and Treatment
- Epigenetics and DNA Methylation
- Infrared Thermography in Medicine
- Infectious Diseases and Mycology
- PARP inhibition in cancer therapy
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
Erasmus MC Cancer Institute
2016-2025
Erasmus MC
2010-2025
Rotterdam University of Applied Sciences
2021-2024
Airlangga University
2024
Erasmus University Rotterdam
2009-2023
University Medical Center Utrecht
2022
Isala
2022
Charité - Universitätsmedizin Berlin
2022
Community Link
2022
Maastricht University Medical Centre
2012-2022
Abstract Introduction Placenta accreta spectrum (PAS) carries a high burden of adverse maternal outcomes, especially significant blood loss, which can be life‐threatening. Different management strategies have been proposed but the association clinical risk factors and surgical options during cesarean delivery with loss is not clear. Material methods In this international multicenter study, 338 women PAS undergoing were included. Fourteen European one non‐European center (USA) provided cases...
Abstract Introduction Placenta accreta spectrum (PAS) is a condition often resulting in severe maternal morbidity. Scheduled delivery by an experienced team has been shown to improve outcomes; however, the benefits must be weighed against risk of iatrogenic prematurity. The aim this study investigate rates emergency seen for antenatally suspected PAS and compare outcomes 15 referral centers International Society (IS‐PAS). Material methods Fifteen provided cases between 2008 2019. women...
Placenta accreta spectrum (PAS) can lead to major peripartum morbidity. Appropriate management approaches depend on the clinical severity, each individual's preference, and treating team's expertise. Peripartum hysterectomy is most frequently used treatment option. However, it impact psychological well-being fertility. We investigated whether conservative with focal resection or leaving placenta in situ associated comparable lower maternal morbidity than centers of excellence within...
To investigate the efficacy of a single prophylactic dose ampicillin combined with metronidazole to prevent postcesarean section infections compared multiple day regimen in low-resource settings.An evaluator-blinded randomized, controlled, noninferiority trial.Two rural hospitals Tanzania.Of 181 enrolled eligible women an indication for cesarean section, information on 176 was analyzed by intention-to-treat.The were randomly assigned either intervention group who received and metronidazole,...
Management options for women with placenta accreta spectrum (PAS) comprise termination of pregnancy before the viable gestational age, leaving in situ subsequent reabsorption or delayed hysterectomy, manual removal after vaginal delivery during cesarean section, focal resection affected uterine wall, and peripartum hysterectomy. The aim this observational study was to describe actual clinical management outcomes PAS a large international cohort.Data from 15 referral centers International...
Topical imiquimod could be an alternative, noninvasive, treatment modality for high-grade cervical intraepithelial neoplasia (CIN). However, evidence is limited, and there are no studies that compared effectiveness side effects of topical cream to standard large loop excision the transformation zone (LLETZ) treatment. A multi-center, nonrandomized controlled trial was performed among women with a histologic diagnosis CIN 2/3. Women were treated either vaginal (6.25 mg 3 times weekly 8 16 wk)...
Abstract Introduction The clinical management of placenta accreta spectrum (PAS) depends on placental topography and vascular involvement. Our aim was to determine whether transabdominal transvaginal ultrasound signs can predict PAS management. Material methods We conducted a retrospective cohort study consecutive prenatally suspected cases in single tertiary‐care center between January 2021 July 2022. When confirmed during surgery, abdominal scans were analyzed relation preferred surgical...
The majority of high-grade serous carcinomas (HGSC) the ovary, fallopian tube, and peritoneum arise from precursor lesion called tubal intraepithelial carcinoma (STIC). It has been postulated that cells STICs exfoliate into peritoneal cavity give rise to HGSC several years later. While co-existent HGSCs have reported share similarities in their mutational profiles, clonal relationship between temporally distant infrequently studied natural history remains poorly understood.
Background: Patients with advanced-stage epithelial ovarian cancer (EOC) receive treatment a poly-ADP ribose-polymerase (PARP) inhibitor (PARPi) as maintenance therapy after surgery and chemotherapy. Unfortunately, many patients experience disease progression because of acquired resistance. This study aims to characterize epigenetic genomic changes in cell-free DNA (cfDNA) associated PARPi Materials Methods: Blood was taken from 31 EOC receiving before at during/after treatment. Resistance...
Abstract Background Cervical cancer is caused by Human Papilloma viruses (HPV) and preceded precursor stages: Intraepithelial Neoplasia (CIN). CIN mostly found in women their reproductive age treated with a Loop Electrosurgical Excision Procedure (LEEP). The recurrence or residual disease rate after treatment up to 17%. These have lifelong increased risk of recurrent CIN, cervical other HPV related malignancies. Furthermore, LEEP treatments are associated complications such as premature...
The aim of this study was to identify differentially methylated regions in cell-free DNA (cfDNA) between healthy persons and patients with advanced stage ovarian cancer (ASOC) differences cfDNA methylation before after cytoreductive surgery. Plasma-derived analyzed by a high-throughput genome wide sequencing technique: MeD-seq. A training set therapy naïve samples ASOC (≥FIGO IIIB, n=10) compared controls (n=10) define specific signature. cumulative hypermethylation score constructed...
Abstract Background Each year, 45,000 women worldwide develop vulvar cancer, often occurred from high-grade squamous intraepithelial lesions (vHSIL), a precancerous stage associated with high- risk human papillomavirus (HPV). Recurrent vHSIL, experienced by over 30% of patients despite treatment, conducting in significant physical and psychosocial challenges. With no established method to reduce recurrence, our study investigates the potential adjuvant HPV vaccination during treatment. We...