Lukáš Dostálek
A5082125095- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Endometriosis Research and Treatment
- Colorectal and Anal Carcinomas
- Uterine Myomas and Treatments
- BRCA gene mutations in cancer
- Cancer Diagnosis and Treatment
- Breast Implant and Reconstruction
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Cancer-related molecular mechanisms research
- Breast Lesions and Carcinomas
- Multiple and Secondary Primary Cancers
- Prenatal Screening and Diagnostics
- Pelvic and Acetabular Injuries
- Management of metastatic bone disease
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Epigenetics and DNA Methylation
- Gynecological conditions and treatments
- Childhood Cancer Survivors' Quality of Life
- Maternal and Perinatal Health Interventions
Charles University
2011-2025
General University Hospital in Prague
2018-2025
Clinica Universidad de Navarra
2024
University of West Bohemia
2020-2023
Fakultní nemocnice Bulovka
2022
Medical University of Graz
2022
Gynecologic Oncology Group
2022
Memorial Sloan Kettering Cancer Center
2022
Hillingdon Hospital
2018
Amsterdam UMC Location University of Amsterdam
2018
Minimally invasive surgery in cervical cancer has demonstrated recent publications worse outcomes than open surgery. The primary objective of the SUCCOR study, a European, multicenter, retrospective, observational cohort study was to evaluate disease-free survival patients with stage IB1 (FIGO 2009) undergoing vs minimally radical hysterectomy. As secondary objective, we aimed investigate association between protective surgical maneuvers and risk relapse. We obtained data from 1272 that...
Endometrial cancer (EC) incidence has been rising over the past 10 years. Delays in diagnosis reduce survival and necessitate more aggressive treatment. We aimed to develop validate a simple, noninvasive, reliable triage test for EC number of invasive diagnostic procedures improve patient survival.We developed screen women with suspected using 726 cervical smear samples from without EC, validated 562 cervicovaginal three different collection methods (cervical smear: n = 248; vaginal swab:...
<h3>Objective</h3> The aim of this study was to compare the incidence intra-operative and post-operative complications in open minimally invasive radical hysterectomy for patients with early-stage cervical cancer. <h3>Methods</h3> Data were collected from SUCCOR database 1272 stage IB1 cancer (International Federation Gynecology Obstetrics (FIGO), 2009) who underwent Europe between January 2013 December 2014. We reviewed duration surgeries, estimated blood loss, length hospital stay,...
<h3>Objective</h3> The aim of this survey was to acquire an overview the current management cervical cancer with emphasis on early disease stages. <h3>Materials and Methods</h3> A hyperlink sent European Society Gynaecological Oncology Office database. contained 6 groups questions regarding characteristics respondents, pretreatment workup, stages cancer, adjuvant treatment, fertility-sparing surveillance. <h3>Results</h3> In total, 566 responses were collected. most frequent imaging method...
The aim of our study was to investigate the control hypertension (HT) in treated children using ambulatory blood pressure (BP) monitoring (ABPM). We retrospectively reviewed all ABPM studies center. Controlled HT defined as systolic and diastolic BP index (patients' divided by 95th percentile) at daytime nighttime <1.0 or alternatively load (percentage readings above <25% on antihypertensive therapy. A total 195 were included. mean age 13.6 ± 4.0 years. One hundred thirty two had...
Avoiding conization may reduce the risk of pre-term labor in future pregnancies, making conservative treatment high-grade cervical dysplasia an increasingly discussed approach, especially for younger patients. However, data on integration individual predictive factors into routine clinical practice remain limited. The primary objective Regression High-Grade Squamous Intraepithelial Cervical Lesions and Associated Risk Factors (RECER) study is to assess rate spontaneous regression squamous...
Background: While sentinel lymph node (SLN) biopsy has been integrated into international guidelines for endometrial cancer, a standardized technique is still lacking. This study addresses whether the concurrent use of two tracers, technetium-99 (Tc) and indocyanine green (ICG), administered intracervically through distinct techniques, enhances performance SLN biopsies. As blue dye used routinely by some centers, it can be alone; however, our analysis focused on only Tc ICG (as in majority...
The data on the prognostic significance of low volume metastases in lymph nodes (LN) are inconsistent. aim this study was to retrospectively analyze outcome a large group patients treated with sentinel node (SLN) biopsy at single referral center. Patients cervical cancer, stage T1a-T2b, common tumor types, negative LN preoperative staging, by primary surgery between 01/2007 and 12/2016, least unilateral SLN detection were included. abandoned radical due intraoperative positivity detected...
Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. The present study aimed to determine frequency of germline pathogenic variants (PV) patients with EC. In this multicenter retrospective cohort study, genetic testing (GGT) was performed 527 EC using a next generation sequencing panel targeting 226 genes, including 5 Lynch syndrome (LS) and 14 hereditary breast ovarian (HBOC) predisposition 207 candidate genes. Gene-level risks were calculated 1,662...
Background The management of patients with intraoperative detection lymph node involvement remains controversial. most significant aspect is the decision regarding completion cervical procedure, such as hysterectomy, radical or a fertility sparing procedure. Primary objective primary ABandoning RAd hyst in cerviX cancer (ABRAX) trial to determine whether procedure (ie, hysterectomy) improves oncological outcome intraoperatively detected before they are referred for definitive chemoradiation....
Abstract Objective Based on the SUCCOR study database, our primary objective was to identify independent clinical pathological variables associated with risk of relapse in patients stage IB1 cervical cancer who underwent a radical hysterectomy. Our secondary goal design and validate predictive index (RPI) for classifying depending recurrence. Methods Overall, 1116 women were included from January 2013 December 2014. We randomly divided sample into two cohorts: discovery validation cohorts....
The incidence of endometrial cancer is rising. Measures to identify women at risk and detect earlier are required reduce the morbidity triggered by aggressive treatment for advanced cancer. We developed WID-EC (Women's IDentification-Endometrial Cancer) test, which based on DNA methylation 500 CpG sites, in a discovery set cervical liquid-based cytology samples from 1086 with without an (217 cases 869 healthy controls) worse prognosis (grade 3 or ≥stage IB). validated test independent...