Barbara Costantini

ORCID: 0000-0002-1414-0106
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About
Contact & Profiles
Research Areas
  • Ovarian cancer diagnosis and treatment
  • Intraperitoneal and Appendiceal Malignancies
  • Endometrial and Cervical Cancer Treatments
  • Endometriosis Research and Treatment
  • Uterine Myomas and Treatments
  • Colorectal Cancer Surgical Treatments
  • Minimally Invasive Surgical Techniques
  • Cardiac, Anesthesia and Surgical Outcomes
  • Renal cell carcinoma treatment
  • Ovarian function and disorders
  • Surgical Simulation and Training
  • Ureteral procedures and complications
  • Appendicitis Diagnosis and Management
  • Growth Hormone and Insulin-like Growth Factors
  • Cervical Cancer and HPV Research
  • Gastric Cancer Management and Outcomes
  • Phytoestrogen effects and research
  • Reproductive Biology and Fertility
  • Intestinal and Peritoneal Adhesions
  • Bladder and Urothelial Cancer Treatments
  • Hemodynamic Monitoring and Therapy
  • Respiratory Support and Mechanisms
  • Nutrition and Health in Aging
  • BRCA gene mutations in cancer
  • Renal and Vascular Pathologies

Università Cattolica del Sacro Cuore
2015-2025

Agostino Gemelli University Polyclinic
2016-2025

Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025

Saint Camillus International University of Health and Medical Sciences
2023-2025

Public Health Department
2021

University of Palermo
2021

Catholic University of America
2015

University of the Sacred Heart
2011-2014

University of Perugia
2014

IRCCS Materno Infantile Burlo Garofolo
2014

Objective To investigate whether neoadjuvant chemotherapy followed by interval debulking surgery is superior to primary in terms of perioperative complications and progression-free survival, advanced epithelial ovarian, fallopian tube or peritoneal cancer patients with high tumor load. Methods Patients (stage IIIC-IV) underwent laparoscopy. load assessed a standardized laparoscopic predictive index were randomly assigned (1:1 ratio) undergo either adjuvant (arm A), B). Co-primary outcome...

10.1136/ijgc-2020-001640 article EN cc-by-nc-nd International Journal of Gynecological Cancer 2020-10-07

Expansion of regulatory T cells occurs in high-risk myelodysplastic syndrome and correlates with a poor prognosis. DNA methyltransferase inhibitors, particularly 5-azacytidine, have been shown to increase the survival patients syndrome. It is not entirely clear whether this improvement patients’ related effects inhibitors on immune system and/or direct effect these drugs dysplastic clone. In study we investigated 5-azacytidine function proliferation capability T-helper cells. The number CD4+...

10.3324/haematol.2012.074823 article EN cc-by-nc Haematologica 2012-12-14

Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background Airway closure causes lack of communication between proximal airways and alveoli, making tidal inflation start only after a critical airway opening pressure is overcome. The authors conducted matched cohort study to report the existence this phenomenon among obese patients undergoing general anesthesia. Methods Within procedures clinical trial during gynecological surgery, underwent...

10.1097/aln.0000000000002662 article EN Anesthesiology 2019-03-22

PURPOSE To investigate whether the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to secondary cytoreductive surgery (SCS) without neoadjuvant has a benefit on progression-free survival (PFS), as opposed SCS alone in patients with platinum-sensitive recurrent epithelial ovarian cancer (platinum-free interval, >6 months). METHODS This was multicenter randomized phase III study. Random assignment performed at time cases residual tumor ≤0.25 cm. HIPEC cisplatin (CDDP) 75 mg/m...

10.1200/jco.24.00686 article EN Journal of Clinical Oncology 2024-11-21

Context: The wide family of the phytoestrogens has become an alternative to classical hormonal therapy in menopause; nevertheless, some findings are still conflicting. Objective: To examine effect genistein administration on metabolic parameters and vascular reactivity considering basal endocrine status patients. Design Setting: A randomized placebo controlled study was conducted at a university hospital. Participants: Fifty postmenopausal women participated. Interventions: Thirty subjects...

10.1210/jc.2008-0735 article EN The Journal of Clinical Endocrinology & Metabolism 2008-11-19

The primary endpoint of this study was to compare the disease-free survival patients undergoing open versus minimally invasive pelvic exenteration. secondary endpoints were cancer-specific and peri-operative morbidity.A multi-center, retrospective, observational cohort undertaken. Patients curative palliative anterior or total exenteration for gynecological cancer by a approach an between June 2010 May 2021 included. with distant metastases excluded. A 1:2 propensity match analysis performed...

10.1136/ijgc-2022-003954 article EN cc-by-nc-nd International Journal of Gynecological Cancer 2023-01-02
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