A5087564490- Sarcoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cardiac tumors and thrombi
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Acute Myeloid Leukemia Research
- Protein Degradation and Inhibitors
- Neurofibromatosis and Schwannoma Cases
- Cell Adhesion Molecules Research
- Meat and Animal Product Quality
- Gastrointestinal disorders and treatments
- Vascular Tumors and Angiosarcomas
- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- Chronic Myeloid Leukemia Treatments
- Renal and related cancers
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Ubiquitin and proteasome pathways
- Listeria monocytogenes in Food Safety
- Probiotics and Fermented Foods
- Food Safety and Hygiene
- Gastric Cancer Management and Outcomes
- Electric Motor Design and Analysis
- Identification and Quantification in Food
University of Bologna
2016-2025
Azienda USL di Bologna
2024
Policlinico S.Orsola-Malpighi
2011-2021
University of Ferrara
2019
Cancer Research Center
2013
Biocom
2013
Portland VA Medical Center
2011
Novartis (Italy)
2011
Canada's Michael Smith Genome Sciences Centre
2011
Oregon Health & Science University
2011
Approximately 10%–15% of gastrointestinal stromal tumors (GISTs) in adults do not harbor any mutation the KIT or PDGFRA genes (ie, KIT/PDGFRA wild-type GISTs). Recently, mutations SDHB and SDHC (which encode succinate dehydrogenase subunits B C, respectively) but SDHA SDHD A D, were identified GISTs. To search for novel pathogenic mutations, we sequenced tumor transcriptome two young adult patients who developed sporadic GISTs by using a massively parallel sequencing approach. The only...
To report on imatinib mesylate (IM) in patients with metastatic dermatofibrosarcoma protuberans (DFSP)/fibrosarcomatous (FS)-DFSP and the impact of treatment tumor biology.Ten consecutive treated IM from 2007 to 2015 for a relapse DFSP/FS-DFSP were identified. FISH analysis COL1A1-PDGFB was performed. Two IM-treated 4 naïve FS-DFSP transcriptionally profiled by RNAseq HiScanSQ platform. Differential gene expression analyzed edgeR (Bioconductor), followed hierarchical clustering Principal...
About 10-15% of adult gastrointestinal stromal tumors (GIST) and the vast majority pediatric GIST do not harbour KIT or platelet-derived growth factor receptor alpha (PDGFRA) mutations (J Clin Oncol 22:3813–3825, 2004; Hematol North Am 23:15–34, 2009). The molecular biology these GIST, originally defined as KIT/PDGFRA wild-type (WT), is complex due to existence different subgroups with distinct hallmarks, including defects in succinate dehydrogenase (SDH) neurofibromatosis type 1 (NF1),...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there still no effective therapy. In order to identify genetic alterations useful new treatment design, we used whole-exome sequencing analyze 14 BPDCN patients the patient-derived CAL-1 line. The functional enrichment analysis of mutational data reported epigenetic regulatory program be most significantly undermined (P
Uterine Leiomyosarcoma (uLMS) is by far the most common type of uterine sarcoma, characterized an aggressive clinical course, a heterogeneous genetic profile and very scarce response to cytotoxic chemotherapy. The make-up uLMS area active study that could provide essential cues for development new therapeutic approaches. A total 216 patients with from cBioPortal AACR-GENIE databases were included in study. vast majority (81%) carried at least one mutation either TP53, RB1, ATRX or PTEN....
Peripheral T-cell lymphoma not otherwise specified represents a diagnostic category comprising clinically, histologically, and molecularly heterogeneous neoplasms that are poorly understood. The genetic landscape of peripheral remains largely undefined, only few sequencing studies having been conducted so far. In order to improve our understanding the genetics this neoplasm, we performed whole exome along with RNA-sequencing in discovery set 21 cases. According results mutations previously...
Abstract FGFR inhibitors have been developed to inhibit activation and signal transduction; notwithstanding, currently the selection of intrahepatic cholangiocarcinoma (iCCA) patients for these drugs only relies on detection FGFR2 genetic alterations (GAs) in tumor tissues or circulating DNAs, without concomitant assessment signalling status. Accordingly, we performed multi-omic analyses genes molecules tissue samples from 36 iCCA naïve patients. Gain-of-function GAs were detected 7...
This systematic review aimed to compile the available body of knowledge about microbiome-related nutritional interventions contributing improve chicken health and having an impact on reduction colonization by foodborne pathogens in gut. Original research articles published between 2012 2022 were systematically searched Scopus PubMed. A total 1,948 retrieved 140 fulfilled inclusion criteria. Overall, 73 papers described 99 against Escherichia coli related organisms; 10 15 Campylobacter spp.;...
// Annalisa Astolfi 1, 2 , Fraia Melchionda Daniela Perotti 3 Maura Fois Valentina Indio 1 Milena Urbini Chiara Giusy Genovese Paola Collini 4 Nunzio Salfi 5 Marilina Nantron 6 Paolo D'Angelo 7 Filippo Spreafico 8 Andrea Pession "Giorgio Prodi" Cancer Research Center, University of Bologna, Italy Pediatric Hematology and Oncology Unit, S.Orsola-Malpighi Hospital, Unit Molecular Bases Genetic Risk Testing, Department Preventive Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei...
Quadruple wild-type (WT) gastrointestinal stromal tumor (GIST) is a genomic subgroup lacking KIT/PDGFRA/RAS pathway mutations, with an intact succinate dehydrogenase (SDH) complex. The aim of this work to perform wide comprehensive study on quadruple WT GIST improve the characterization these patients. We selected 14 clinical cases GIST, which nine showed sufficient DNA quality for whole exome sequencing (WES). NF1 alterations were identified directly by WES. Gene expression from...
Next generation sequencing (NGS) technology has been rapidly introduced into basic and translational research in oncology, but the reduced availability of fresh frozen (FF) tumor tissues poor quality DNA extracted from formalin-fixed, paraffin-embedded (FFPE) significantly impaired this process field solid tumors. To evaluate if data generated FFPE material can be reliably produced potentially used routine clinical settings, we performed whole exome (WES) samples Gastrointestinal stromal...
Few studies were conducted investigating the immunological profiles in gastrointestinal stromal tumors (GIST). Adaptive and innate immune cells are present tumor microenvironment, indicating GIST as inflamed tumors. In addition, murine models suggested a potential interaction between components imatinib. this retrospective study, profile was investigated through silico analysis immunohistochemistry (IHC), exploring basis for immunotherapy approaches. Gene expression (GEP) from 31...
Long non-coding RNAs (lncRNAs) are ncRNAs more than 200 nucleotides long that participate to a wide range of biological functions. However, their role in cancer is poorly known. By using an NGS-based approach we analyzed the intragenic and poliA-lncRNAs hepatocellular carcinoma (HCC) assayed relationships between deregulated expression clinical-pathological characteristics. The profile lncRNAs was studied discovery series 28 HCC matched cirrhosis validated independent cohort 32 patients both...
Extraskeletal myxoid chondrosarcoma (EMC) is a very rare sarcoma most often arising in the soft tissue. Rare EMC of bone have been reported. exhibits distinctive clinico-pathological and genetic features; however, despite name, it lacks any feature cartilaginous differentiation. characterized by rearrangement NR4A3, which, cases (about 62-75%), fused with EWSR1 less frequently other partners, including TAF15 (27%), TCF12 (4%), TFG, FUS. We herein report identification whole-transcriptome...
Nowadays functional ingredients have a significant potential for improving current low fish meal (FM) aquafeed formulation in sustaining growth and enhancing animal robustness Mediterranean aquaculture. Among them, nucleotides (NT) nucleic acids (NA) drew attention their application the last two decades. NT are organic molecules involved many life-supporting pathways, building blocks of NA, which stand as genetic repositories. naturally present ingredients, among them FM is known to be one...
The assessment of histamine levels in fishery products has emerged as a paramount issue the context global food safety, given its profound implications for human health and consequential impact on quality trade. Histamine intoxication, stemming from ingestion foods containing heightened levels, results bacterial decarboxylation histidine under conditions improper handling, processing, or storage. This study endeavors to provide thorough examination contamination frozen-thawed tuna (Thunnus...
In this study, the antimicrobial effect of Citrus limon peel extract against Listeria monocytogenes was analyzed in silico, tested vitro, and validated fermented cow milk during cold storage. The silico analysis revealed that 4,5-di-O-caffeoyquinic acid interacts with L. proteins involved colonization intracellular survival. vitro experiments demonstrated anti-Listeria activity is primarily attributed to limonene phenolic compounds. stored at 4 °C for 7 days, addition resulted a 2 Log...
CBFA2T3-GLIS2 is a fusion gene found in 17% of non-Down syndrome acute megakaryoblastic leukemia (non-DS AMKL, FAB M7) and 8% pediatric cytogenetically normal myeloid (CN-AML, association with several French-American-British (FAB) subtypes). Children AML harboring this aberration have poor outcome, regardless the subtype. This drives peculiar expression pattern leads to overexpression some Hedgehog-related genes. GLI-similar protein 2 (GLIS2) closely related GLI family, final effectors...