A5011935671- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Molecular Biology Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Renal and related cancers
- Sarcoma Diagnosis and Treatment
- Testicular diseases and treatments
- Colorectal Cancer Treatments and Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cutaneous Melanoma Detection and Management
- Genetic factors in colorectal cancer
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Urinary and Genital Oncology Studies
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
University of Bologna
2016-2025
Azienda USL di Bologna
2018-2025
Harvard University
2013-2024
March of Dimes
2023
Policlinico S.Orsola-Malpighi
2013-2022
Agostino Gemelli University Polyclinic
2022
Università Cattolica del Sacro Cuore
2022
Memorial Sloan Kettering Cancer Center
2022
Massachusetts General Hospital
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2022
Detection of critical cancer gene mutations in clinical tumor specimens may predict patient outcomes and inform treatment options; however, high-throughput mutation profiling remains underdeveloped as a diagnostic approach. We report the implementation genotyping validation algorithm that enables robust setting.We developed implemented an optimized platform ("OncoMap") to interrogate approximately 400 33 known oncogenes suppressors, many which are response or resistance targeted therapies....
Purpose Gleason grading is an important predictor of prostate cancer (PCa) outcomes. Studies using surrogate PCa end points suggest outcomes for score (GS) 7 cancers vary according to the predominance pattern 4. These studies have influenced clinical practice, but it unclear if rates mortality differ 3 + 4 and tumors. Using as primary point, we compared in cancers, predictive ability GS from a standardized review versus original scoring. Patients Methods Three study pathologists conducted...
Overexpression of the fatty acid synthase (FASN) gene has been implicated in prostate carcinogenesis. We sought to directly assess oncogenic potential FASN. used immortalized human epithelial cells (iPrECs), androgen receptor–overexpressing iPrECs (AR-iPrEC), and adenocarcinoma LNCaP that stably overexpressed FASN for cell proliferation assays, soft agar tests tumor formation immunodeficient mice. Transgenic mice expressing were generated effects on histology. Apoptosis was evaluated by...
Background: PTEN is a tumor suppressor frequently deleted in prostate cancer that may be useful prognostic biomarker.However, the association of loss with lethal disease has not been tested large, predominantly surgically treated cohort. Methods:In Health Professionals Follow-up Study and Physicians' Study, we followed 1044 incident cases diagnosed between 1986 2009 for cancer-specific all-cause mortality.A genetically validated immunohistochemistry (IHC) assay was performed on tissue...
Anticancer therapies have been limited by the emergence of mutations and other adaptations. In bacteria, antibiotics activate SOS response, which mobilizes error-prone factors that allow for continuous replication at cost mutagenesis. We investigated whether treatment lung cancer with EGFR inhibitors (EGFRi) similarly engages hypermutators. cycling drug-tolerant persister (DTP) cells in EGFRi-treated patients presenting residual disease, we observed upregulation GAS6, whereas ablation GAS6's...
Purpose Prostate-specific antigen screening has led to enormous overtreatment of prostate cancer because the inability distinguish potentially lethal disease at diagnosis. We reasoned that by identifying an mRNA signature Gleason grade, best predictor prognosis, we could improve prediction among men with moderate 7 tumors, most common and indeterminate in terms prognosis. Patients Methods Using complementary DNA–mediated annealing, selection, extension, ligation assay, measured expression...
Abstract Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked risk prostate cancer progression mortality, but the molecular underpinnings this association poorly understood. Here, we demonstrate in a murine model, that high-fat diet (HFD) enhances MYC transcriptional program through favour histone H4K20 hypomethylation at promoter regions regulated genes, leading to cellular proliferation tumour burden. Saturated intake (SFI) is also an...
Purpose Data suggest that circulating 25-hydroxyvitamin D [25(OH)D] interacts with the vitamin receptor (VDR) to decrease proliferation and increase apoptosis for some malignancies, although evidence prostate cancer is less clear. How VDR expression in tumor tissue may influence progression has not been evaluated large studies. Patients Methods We examined protein of among 841 patients relation risk lethal within two prospective cohorts, Physicians' Health Study Professionals Follow-Up...
Fatty acid synthase (FASN) regulates de novo lipogenesis, body weight, and tumor growth. We examined whether common germline single nucleotide polymorphisms (SNPs) in the FASN gene affect prostate cancer (PCa) risk or PCa-specific mortality these effects vary by mass index (BMI).
Abstract Colorectal cancer ( CRC ) is the second leading cause of cancer‐related mortality in Western countries. Although aberrant expression several microRNAs oncomiRs associated with progression, molecular mechanisms this phenomenon are still under investigation. Here we show that miR ‐101 differentially impaired specimens, depending on tumour grade. re‐expression suppresses cell growth 3D , hypoxic survival and invasive potential cells showing low levels . Additionally, provide evidence a...
While progression from normal prostatic epithelium to invasive cancer is driven by molecular alterations, tumor cells and in the microenvironment are co-dependent co-evolve. Few human studies date have focused on stroma. Here, we performed gene expression profiling of laser capture microdissected non-neoplastic prostate epithelial tissue compared it non-transformed neoplastic low-grade high-grade radical prostatectomies, each with its immediately surrounding Whereas benign prostates without...
Abstract Background: Overexpression of prostate-specific membrane antigen (PSMA) in tumor tissue and serum has been linked to increased risk biochemical recurrence surgically treated prostate cancer patients, but none the studies have assessed its association with disease-specific mortality. Methods: We examined whether high PSMA protein expression was associated lethal disease, biomarkers progression, among participants two U.S.-based cohorts (n = 902, diagnosed 1983–2004). used Cox...
Abstract Italy was the first European nation to be massively infected by SARS‐CoV‐2. Up end of May 2020, more than 33,000 deaths had been recorded in Italy, with a large prevalence among males, those over 75 years age, and association co‐morbidities. We describe lung pathological immunohistochemical post‐mortem findings at autopsy nine patients who died SARS‐CoV‐2‐associated disease. found tissues all histological changes consistent diffuse alveolar damage various evolution phases ranging...
Background Ultra-short coeliac disease (USCD) is defined as villous atrophy only present in the duodenal bulb (D1) with concurrent positive serology. We first, multicentre, international study of patients USCD. Methods Patients USCD were identified from 10 tertiary hospitals (6 Europe, 2 Asia, 1 North America and Australasia) compared age-matched sex-matched conventional disease. Findings (n=137, median age 27 years, IQR 21–43 years; 73% female) younger than those (27 vs 38 respectively,...
To analyze the potential diagnostic relevance of free plasma DNA (FPDNA), we enrolled 64 patients with localized prostate cancer (CaP). FPDNA was quantified by real-time polymerase chain reaction assessment HTERT gene in blood samples from CaP and 45 healthy males. Methylation GSTP1 used to confirm neoplastic origin selected cases. The mean +/- SD levels were higher (15.4 10.9 ng/mL) than control subjects (5.5 3.5 ng/mL; P <.001). By using best cutoff value, sensitivity test 80%, specificity...