A5016727101- HER2/EGFR in Cancer Research
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
- Gene expression and cancer classification
- Advanced Biosensing Techniques and Applications
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Lung Cancer Treatments and Mutations
- Molecular Biology Techniques and Applications
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Advanced Proteomics Techniques and Applications
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Advanced Breast Cancer Therapies
German Cancer Research Center
2016-2025
Heidelberg University
2016-2025
DKFZ-ZMBH Alliance
2005-2024
Deutschen Konsortium für Translationale Krebsforschung
2020-2024
German Cancer Society
2024
Charité - Universitätsmedizin Berlin
2024
Weizmann Institute of Science
2023
Imperial College London
2023
Heidelberg University
2004-2021
Institut Cochin
2014
Medulloblastoma is the most common brain tumour in children; using whole-genome sequencing of samples authors show that clinically challenging Group 3 and 4 tumours can be tetraploid, reveal expression first medulloblastoma fusion genes identified. malignant children. Four papers published 2 August 2012 issue Nature use other techniques to produce a detailed picture genetics genomics this condition. Notable findings include identification recurrent mutations not previously implicated...
In breast cancer, overexpression of the transmembrane tyrosine kinase ERBB2 is an adverse prognostic marker, and occurs in almost 30% patients. For therapeutic intervention, targeted by monoclonal antibody trastuzumab adjuvant settings; however, de novo resistance to this still a serious issue, requiring identification additional targets overcome resistance. study, we have combined computational simulations, experimental testing simulation results, finally reverse engineering protein...
KEGG PATHWAY is a service of Kyoto Encyclopedia Genes and Genomes (KEGG), constructing manually curated pathway maps that represent current knowledge on biological networks in graph models. While valuable tools have been implemented R/Bioconductor, to our there currently no software package parse analyze pathways with theory.We introduce the KEGGgraph R Bioconductor, an interface between models as well collection for these graphs. Superior existing approaches, captures topology allows...
Epithelial-mesenchymal transition (EMT) is an initiating event in tumor cell invasion and metastasis. It has been shown to occur resistance a range of cancer therapies, including tamoxifen. MicroRNAs (miRNAs) have associated with EMT as well standard therapies. To investigate the role miRNAs development tamoxifen accompanying EMT-like properties, we established tamoxifen-resistant (TamR) model by continually exposing MCF-7 breast cells In addition molecular changes known be involved acquired...
MicroRNAs (miRNAs) as modulators of gene expression have been described to display both tumor-promoting and tumor-suppressive functions. Although their role has studied in different tumor types, little is known about how they regulate nuclear factor κB (NF-κB) signaling breast cancer. Here, we performed an unbiased whole genome miRNA (miRome) screen identify novel NF-κB pathway The identified 13 families whose members induced consistent effects on activity. Among those, the miR-520/373...
The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly understood. secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 encodes structurally related phosphoproteins which some are specifically expressed high levels in the glands and constitute major components saliva. Here we report on recurrent rearrangements [t(4;9)(q13;q31)] AciCC that translocate active enhancer regions from SCPP to region upstream Nuclear Receptor Subfamily 4 Group A Member 3...
The tumor microenvironment (TME) plays key roles in promoting disease progression the aggressive triple-negative subtype of breast cancer (TNBC; Basal/Basal-like). Here, we took an integrative approach and determined impact tumor-stroma-inflammation networks on pro-metastatic phenotypes TNBC. With TCGA dataset found that pro-inflammatory cytokines necrosis factor α (TNFα) interleukin 1β (IL-1β), as well their target chemokines CXCL8 (IL-8), CCL2 (MCP-1), CCL5 (RANTES) were expressed at...
Anticancer therapies have been limited by the emergence of mutations and other adaptations. In bacteria, antibiotics activate SOS response, which mobilizes error-prone factors that allow for continuous replication at cost mutagenesis. We investigated whether treatment lung cancer with EGFR inhibitors (EGFRi) similarly engages hypermutators. cycling drug-tolerant persister (DTP) cells in EGFRi-treated patients presenting residual disease, we observed upregulation GAS6, whereas ablation GAS6's...
MicroRNA-200c (miR-200c) has been shown to suppress epithelial-mesenchymal transition (EMT), which is attributed mainly targeting of ZEB1/ZEB2, repressors the cell-cell contact protein E-cadherin. Here we demonstrated that modulation miR-200c in breast cancer cells regulates cell migration, elongation, and transforming growth factor β (TGF-β)-induced stress fiber formation by impacting reorganization cytoskeleton independent ZEB/E-cadherin axis. We identified FHOD1 PPM1F, direct regulators...
Cell migration is essential during development and in human disease progression including cancer. Most cell studies concentrate on known or predicted components of pathways.
Carney triad (CT) is a rare condition with synchronous or metachronous occurrence of gastrointestinal stromal tumors (GISTs), paragangliomas (PGLs), and pulmonary chondromas in patient. In contrast to Carney–Stratakis syndrome (CSS) familial PGL syndromes, no germline somatic mutations the succinate dehydrogenase ( SDH ) complex subunits A , B C D have been found most and/or patients CT. Nonetheless, arising among CT, CSS, share similar morphology loss SDHB subunit on protein level. For...
Non-coding RNAs are much more common than previously thought. However, for the vast majority of non-coding RNAs, cellular function remains enigmatic. The two long RNA (lncRNA) genes DLEU1 and DLEU2 map to a critical region at chromosomal band 13q14.3 that is recurrently deleted in solid tumors hematopoietic malignancies like chronic lymphocytic leukemia (CLL). While no point mutations have been found protein coding candidate 13q14.3, they deregulated malignant cells, suggesting an epigenetic...