A5089678051- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Oral and Maxillofacial Pathology
- Reconstructive Surgery and Microvascular Techniques
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Tracheal and airway disorders
- Augmented Reality Applications
- 3D Shape Modeling and Analysis
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Obstructive Sleep Apnea Research
- Tumors and Oncological Cases
- Healthcare Operations and Scheduling Optimization
- Radiomics and Machine Learning in Medical Imaging
- Bone Tumor Diagnosis and Treatments
- Lung Cancer Treatments and Mutations
- Cardiac, Anesthesia and Surgical Outcomes
- Facial Nerve Paralysis Treatment and Research
- Vascular Procedures and Complications
University Hospital Heidelberg
2019-2025
Heidelberg University
2019-2025
University Medical Centre Mannheim
2020-2024
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2020-2024
Medizinische Fakultät Mannheim
2021-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2023
Universitäts HNO Klinik Mannheim
2020-2023
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2021-2023
University of Mannheim
2019-2021
Universitätsklinikum Erlangen
2015-2021
The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly understood. secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 encodes structurally related phosphoproteins which some are specifically expressed high levels in the glands and constitute major components saliva. Here we report on recurrent rearrangements [t(4;9)(q13;q31)] AciCC that translocate active enhancer regions from SCPP to region upstream Nuclear Receptor Subfamily 4 Group A Member 3...
ABSTRACT Background The purpose of this study was to evaluate risk factors that influence overall survival (OS)/disease‐free (DFS)/locoregional recurrence‐free (LRFS), and distant metastases‐free (DMFS) in patients with high‐risk primary salivary gland carcinoma who underwent surgery postoperative (chemo)radiotherapy curative intention. Methods We reviewed data 63 a retrospective single‐center audit. Results At median follow‐up 31 months (range, 5–145 months), cumulative OS DFS were 91.7%,...
<b><i>Introduction:</i></b> Augmented reality can improve planning and execution of surgical procedures. Head-mounted devices such as the HoloLens® (Microsoft, Redmond, WA, USA) are particularly suitable to achieve these aims because they controlled by hand gestures enable contactless handling in a sterile environment. <b><i>Objectives:</i></b> So far, systems have not yet found their way into operating room for surgery parotid gland. This...
Abstract Small extracellular vesicles from saliva (SEVs) have high potential as biomarkers in Head and Neck cancer (HNC). However, there is no common consensus on the ideal method for their isolation. This study compared different ultracentrifugation (UC) methods (durations + /− additional purification) with size exclusion chromatography (SEC) investigated of SEVs diagnostic biological activity NK CD8 T cells. 19 HNC patients 8 healthy donors (HDs) were thoroughly characterized. Transmission...
<b><i>Introduction:</i></b> A 2½ D point cloud registration method was developed to generate digital twins of different tissue shapes and resection cavities by applying a machine learning (ML) approach. This demonstrates the feasibility quantifying soft shifts. <b><i>Methods:</i></b> An ML model trained using simulated surface scan data obtained from tumor resections in pig head cadaver model. It hereby uses 438 scans surface. Tissue shift...
Background Current standard treatment concepts in head and neck squamous cell carcinoma (HNSCC) are based on former studies using 2D 3D plans. However, modern radiation techniques allow for a more precise individual dose application. Therefore, clearly defined patient population, de-intensified risk-adapted is investigated. Methods Patients with newly diagnosed HNSCC after surgery (with resection margins ≥1 mm cM0) the following tumor stages (TNM 7th Edition) were eligible study: oral...
Soft-tissue surgeries, such as tumor resections, are complicated by tissue deformations that can obscure the accurate location and shape of tissues. By representing surfaces point clouds applying non-rigid cloud registration (PCR) methods, surgeons better understand before, during, after surgery. Existing PCR feature-based approaches, struggle with robustness against challenges like noise, outliers, partial data, large deformations, making correspondence difficult. Although learning-based...
Bell´s palsy is the most common cause of facial paralysis worldwide and disorder cranial nerves. It a diagnosis exclusion, accounting for 60-75% all acquired peripheral nerve palsies. Our case shows first microcystic adnexal carcinoma-like squamous cell carcinoma as palsy.The patient, 70-year-old Caucasian male, experienced subsequent functional impairment trigeminal glossopharyngeal about 1½ years after refractory palsy. An extensive clinical work-up tissue biopsy surrounding parotid gland...
The ideal extent of surgical intervention for benign parotid tumors remains a matter controversy. purpose this study was to examine the existing arguments against extracapsular dissection and present our experience over last 16 years.A retrospective evaluation carried out on records all patients who underwent at tertiary referral center between 2000 2015.A total 1359 cases were included in study. Temporary postoperative facial palsy detected 68 (5%), permanent 5 (0.37%), Frey's syndrome 31...
Objectives/Hypothesis To evaluate the demographics, clinical features, management, and prognostic indicators of tracheoesophageal puncture complications in patients undergoing placement voice prosthesis following cancer treatment. Study Design Retrospective analysis. Methods A retrospective analysis was conducted cases from a tertiary referral center diagnosed between 1996 2015. Multivariate logistic regression used to determine factors associated with (TEP) prostheses–complication‐free...
Although checkpoint inhibitors (CPI) have recently extended the treatment options and improved clinical response of advanced stage head neck squamous cell carcinoma (HNSCC), success remains unpredictable. Programmed death ligand‑1 (PD‑L1) is a key player in immunotherapy. Tumor cells, exosomes derived therefrom, are carriers PD‑L1 efficiently suppress immune responses. The aim present study was to analyze influence established therapies on expression HNSCC lines their exosomes. lines,...
Salivary duct carcinomas (SDC) of the parotid gland are rarely occurring highly malignant tumors. A 65-year-old man presented with a preauricular mass. After surgical treatment and histologic examination, findings were interpreted as squamous cell carcinoma (SCC) metastasis deriving from cancer unknown primary DD SCC gland. Adjuvant platinum-based radiochemotherapy was administered in domo. However, re-staging revealed multiple size-progressive pulmonary round lesions. resection histological...
The aim of this study was to establish a standardized protocol for drug-induced sleep endoscopy (DISE) differentiate obstruction patterns in obstructive apnea (OSA). Target-controlled infusion (TCI) the sedative propofol combined with real-time monitoring depth sedation using bispectral analysis. In an observational 57 patients (mean age 44.8 years, ± SD 10.5; mean hypopnea Index (AHI) 30.8/hr, 21.6, BMI 28.2 kg/m2, 5.3) underwent cardiorespiratory polysomnography followed by DISE TCI and...
Abstract Purpose Free flap reconstruction is a valuable technique to preserve function in oncological head and neck surgery. Postoperative graft thrombosis dreaded risk. This study aims compare low-dose unfractionated heparin (UFH) low-molecular-weight (LMWH) perioperative prophylaxis. Methods retrospective analysis of 266 free flaps performed at our academic center. A comparison was made between 2 patient groups, based on their respective postoperative prophylaxis protocols either with UFH...
<b><i>Background:</i></b> Nicotine contributes to tumorigenesis through stimulation of nicotinic acetylcholine receptors (nAChRs) in head and neck squamous cell carcinoma (SCC). Although many factors have been found be involved the pathogenesis cancer, effect nAChRs is still unclear. The study provides information on different subtypes SCC normal mucosa (NM) their clinicopathological correlation tumor progression. <b><i>Methods:</i></b> (n =...
Introduction The kinetic of C-reactive protein (CRP) in the early phase therapy with checkpoint inhibitors (CPI) and its prognostic value has already been investigated several tumor entities. In particular, flare dynamics have described as a positive parameter. aim this retrospective study is to examine extent which such an application can also be transferred patients recurrent or metastatic squamous cell carcinoma head neck region (R/M-HNSCC). Material Methods All treated CPI for R/M-HNSCC...
Background A limited number of single institutions have published retrospective cohort studies on transoral laser microsurgery for supraglottic laryngectomy (TLM-SGL). These shown that the oncologic outcomes TLM-SGL are comparable to those open SGL. However, there is information available regarding swallowing rehabilitation and quality life (QoL). Patients methods SUPRATOL a prospective, multicenter trial assessing functional +/− adjuvant radio-(chemo)-therapy. The primary endpoint was...