A5003133336- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Ear and Head Tumors
- Cancer Diagnosis and Treatment
- Nasal Surgery and Airway Studies
- Lung Cancer Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Radiomics and Machine Learning in Medical Imaging
- Anesthesia and Pain Management
- Head and Neck Surgical Oncology
- Reconstructive Surgery and Microvascular Techniques
- Immunotherapy and Immune Responses
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Brain Metastases and Treatment
- Voice and Speech Disorders
- Lung Cancer Treatments and Mutations
- Reconstructive Facial Surgery Techniques
- Facial Nerve Paralysis Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Vestibular and auditory disorders
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2025
Universitätsklinikum Erlangen
2018-2025
Comprehensive Cancer Center Erlangen
2020-2025
Barmherzige Brüder Klinikum St. Elisabeth in Straubing
2023-2024
Krankenhaus Barmherzige Brüder
2024
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2024
Medical University of Vienna
2023
Bayer (Germany)
2020-2022
German Climate Computing Centre
2022
Else Kröner-Fresenius-Stiftung
2021
Deep learning-based head and neck lymph node level (HN_LNL) autodelineation is of high relevance to radiotherapy research clinical treatment planning but still underinvestigated in academic literature. In particular, there no publicly available open-source solution for large-scale autosegmentation HN_LNL the setting.An expert-delineated cohort 35 CTs was used training an nnU-net 3D-fullres/2D-ensemble model 20 different HN_LNL. A second acquired at same institution later time served as test...
Background To determine safety and efficacy of single cycle induction treatment with cisplatin/docetaxel durvalumab/tremelimumab in stage III-IVB head neck cancer. Methods Patients received a cisplatin 30 mg/m² on days 1–3 docetaxel 75 day 1 combined durvalumab 1500 mg fix dose 5 tremelimumab 5. pathologic complete response (pCR) the rebiopsy after or at least 20% increase intratumoral CD8+ cell density compared baseline entered radioimmunotherapy concomitant durvalumab/tremelimumab. The...
Purpose The first aim of the trial is to study feasibility combined programmed death protein ligand 1/cytotoxic T-lymphocyte-associated 4 inhibition concomitant radiotherapy. In addition, efficacy entire treatment scheme consisting induction chemoimmunotherapy followed by chemotherapy-free radioimmunotherapy (RIT) after intratumoral CD8 +immune cell-based patient selection will be analyzed. Methods Patients with stage III–IVB head and neck squamous cell carcinoma were eligible for this...
Abstract Background Head and neck cancer (HNC) patients experience a variety of post-treatment symptoms that affect their quality life (QoL). This study aims to assess the most prevalent relationship stage (UICC I–IV) while identifying areas for targeted intervention. Methods A cross-sectional was conducted involving 340 HNC at University Hospital Erlangen from January December 2019. QoL its domains were assessed using German version Washington Quality Life Questionnaire Version 4 (UW-QoL...
To investigate the prognostic significance of various factors in hearing preservation after traditional cochlear implantation (CI).Retrospective case review.Academic tertiary referral center.A total 153 implantations with mean patient age at 36 years (from 10 mo to 83 yr) and residual frequencies 250, 500, 1,000 Hz on unaided preoperative pure-tone audiometry were included.CI a conventional full-length electrode.The changes 3 months analyzed regarding patients' demographic factors, shape...
Individual prediction of treatment response is crucial for personalized in multimodal approaches against head-and-neck squamous cell carcinoma (HNSCC). So far, no reliable predictive parameters schemes containing immunotherapy have been identified. This study aims to predict induction chemo-immunotherapy based on the peripheral blood immune status patients with locally advanced HNSCC. The phenotype was assessed whole samples treated phase II CheckRad-CD8 trial as part pre-planned...
Evaluation of morphologic and functional long-term results palisade cartilage tympanoplasty (PCT) combined with titanium ossicular replacement prostheses.Retrospective review tympanoplasties.Tertiary referral center.Twenty-nine patients (12 women 17 men; mean age, 39 yr; range, 17-72 yr) operated on more than 9 years ago (mean follow up, 9.1 because cholesteatoma, adhesive otitis, chronic otitis media, subtotal tympanic membrane defects, fibrosis requiring tympanoplasty.Tympanoplasty,...
Superparamagnetic iron oxide nanoparticles (SPIONs) feature distinct magnetic properties that make them useful and effective tools for various diagnostic, therapeutic theranostic applications. In particular, their use in drug targeting (MDT) promises to be an approach the treatment of diseases such as cancer. At cellular level, SPION uptake, along with SPION-mediated toxicity, represents most important prerequisite successful application. Thus, present study determines toxicity...
Objective Assessment of the value transoral laser microsurgery (TLM) compared with open surgery (OS) for early stage squamous cell carcinoma glottic larynx special regard to involvement anterior commissure (AC). Study Design Case series chart review. Setting Tertiary care otolaryngology clinic. Subjects and Methods Review clinicopathological data all patients previously untreated T1a, T1b, T2 who were consecutively enrolled over a 10-year period (January 1, 1992, December 31, 2002). Results...
The lacrimal gland is crucial for maintaining ocular health by producing the aqueous component of tear film, which hydrates and nourishes surface. Decreased production this results in dry eye disease, a condition affecting over 250 million people worldwide. However, scarcity primary human material studying its underlying mechanisms absence cell model epithelial cells present significant challenges. Here, we describe generation immortalized lines through introduction an SV40 antigen. We...
Head and neck cancer (HNC) is a critical concern in oncology, with notable disparities survival rates. While the long-term symptom burden HNC survivors its impact on quality of life (QoL) has been explored, there limited understanding influence localizations these aspects. This study aims to elucidate role shaping outcomes patients.
Abstract Background We aimed to validate the prognostic significance of tumor budding (TB) in p16-positive oropharyngeal squamous cell carcinomas (OPSCC). Methods analyzed digitized H&E-stained slides from a multicenter cohort five large university centers consisting n = 275 cases OPSCC. evaluated TB along with other histological parameters (morphology, tumor-stroma-ratio, lymphovascular invasion (LVI), perineural invasion) and calculated survival outcomes using both univariate...
Conclusion: In detecting a thin bony coverage of superior semicircular canal (SSC), digital volume tomography (DVT) scans in Poeschl projection seem to be high-resolution computed (CT) scans. Still, definite diagnosis SSC dehiscence (SSCD) is not possible with any radiologic imaging technique. Objective: To compare CT and DVT find out whether equal, better or worse showing layer on top an SCC. Methods: 11 human temporal bone specimens, the was microscopically blue-lined leaving it. All...
To describe a method of cochlear implantation in which the opening cochlea and electrode array insertion are performed under water (underwater technique).Retrospective patient review.Academic tertiary referral center.Fifteen implantations children adult patients with residual hearing at frequencies 250, 500, 1000 Hz on unaided preoperative pure-tone audiometry were included this study.Cochlear conventional full-length electrode, after tympanic cavity was filled body-temperature Ringer...
Mucus consistency affects voice physiology and is connected to disorders. Nevertheless, the rheological characteristics of human laryngeal mucus from vocal folds remain unknown. Knowledge about viscoelasticity enables fabrication artificial with natural properties, more realistic ex-vivo experiments promotes a better understanding improved treatment dysphonia regard consistency. We studied samples two complementary approaches: 19 were successfully applied particle tracking microrheology...
To determine whether a single dose of double immune checkpoint blockade (induction chemoimmunotherapy (ICIT)) adds benefit to induction single-cycle platinum doublet chemotherapy (IC)) in locally advanced head and neck squamous cell carcinoma (HNSCC), patients treated with cisplatin 30 mg/m2 d1-3 docetaxel 75 d1 combined durvalumab 1500 mg fixed d5 tremelimumab (ICIT) within the CheckRad-CD8 trial were compared retrospective cohort receiving same (IC) without immunotherapy. The endpoint this...
Abstract Background Immune checkpoint inhibitors (ICI) have become standard treatment in different tumor entities. However, safe with ICI targeting the PD-1/PD-L1 axis requires early detection of immune-related adverse events (irAE). There exist questionnaires drug manufacturers for irAE that not been validated so far. Methods The prospective non-interventional ST-ICI trial studied alone or combined radiotherapy. In current analysis, rate self-reported a patient questionnaire containing 41...
To assess the predictive value of multiparametric MRI for treatment response evaluation induction chemo-immunotherapy in locally advanced head and neck squamous cell carcinoma.Twenty-two patients with advanced, histologically confirmed carcinoma who were enrolled prospective multicenter phase II CheckRad-CD8 trial included current analysis. In this unplanned secondary single-center analysis, all received contrast-enhanced at baseline week 4 after single-cycle therapy cisplatin/docetaxel...