A5010448955- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Colorectal and Anal Carcinomas
- Salivary Gland Tumors Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Meningioma and schwannoma management
- Cytomegalovirus and herpesvirus research
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Surgical Treatments
- Neurological Complications and Syndromes
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Medical Imaging Techniques and Applications
- Cardiac pacing and defibrillation studies
Universitätsklinikum Erlangen
2016-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Comprehensive Cancer Center Erlangen
2019-2025
Bayer (Germany)
2020-2022
Radiation Oncology Associates
2019
Universitätsklinik für Strahlentherapie
2013-2015
American Society of Clinical Oncology
2015
Sabin Vaccine Institute
2014
University of Rostock
2003-2010
Berlin Heart (Germany)
1997-1998
To more fully characterize the clinical and pathologic spectrum of a recently described tumor entity sinonasal tract characterized by loss nuclear expression SMARCB1 (INI1), we analyzed 39 SMARCB1-deficient carcinomas collected from multiple medical centers. The tumors affected 23 males 16 females with an age range 19 to 89 years (median, 52). All patients presented locally advanced disease (T3, n=5; T4, n=27) involving sinuses (mainly ethmoid) variable involvement nasal cavity. Thirty...
4008 Background: Chemotherapy (CT) is the standard of care in nonresectable locally advanced pancreatic cancer. The CONKO-007 trial studied role sequential CT and chemoradiotherapy (CRT). Methods: In this randomized multicenter phase III resectability was judged by an independent surgical board. Patients (pts) received induction chemotherapy (IC) for 3 months (3 cycles gemcitabine (Gem, 1000 mg/m² d1, 8, 15, q4w) or FOLFIRINOX (6 cycles, q2w)). After IC pts without progression were to either...
The potential of large language models in medicine for education and decision-making purposes has been demonstrated as they have achieved decent scores on medical exams such the United States Medical Licensing Exam (USMLE) MedQA exam. This work aims to evaluate performance ChatGPT-4 specialized field radiation oncology.
Background Implantation of mechanical cardiac support systems (MCSS) in patients with idiopathic dilated cardiomyopathy (IDC) may improve function and allow explantation the device. We report long-term effects ventricular unloading on function, humoral anti-β1-adrenoceptor autoantibodies (A-β 1 -AABs), myocardial fibrosis. Methods Results Seventeen New York Heart Association functional class IV nonischemic IDC received MCSS. All had a index <1.6 L · min −1 m −2 body surface area, left...
Poorly differentiated sinonasal carcinomas are a heterogenous group of aggressive neoplasms that encompasses squamous cell carcinoma including basaloid variant, lymphoepithelial carcinoma, undifferentiated and neuroendocrine-type small carcinoma. We herein describe 3 cases hitherto unreported variant combining features with variable intermingled rhabdoid cells. Patients were 2 women (aged 28 35) man (52 y) who presented masses. All had advanced local disease bone involvement (pT4). None...
Deep learning-based head and neck lymph node level (HN_LNL) autodelineation is of high relevance to radiotherapy research clinical treatment planning but still underinvestigated in academic literature. In particular, there no publicly available open-source solution for large-scale autosegmentation HN_LNL the setting.An expert-delineated cohort 35 CTs was used training an nnU-net 3D-fullres/2D-ensemble model 20 different HN_LNL. A second acquired at same institution later time served as test...
Background To determine safety and efficacy of single cycle induction treatment with cisplatin/docetaxel durvalumab/tremelimumab in stage III-IVB head neck cancer. Methods Patients received a cisplatin 30 mg/m² on days 1–3 docetaxel 75 day 1 combined durvalumab 1500 mg fix dose 5 tremelimumab 5. pathologic complete response (pCR) the rebiopsy after or at least 20% increase intratumoral CD8+ cell density compared baseline entered radioimmunotherapy concomitant durvalumab/tremelimumab. The...
Background: While the role of stereotactic radiotherapy for brain metastases is increasing, evidence on comparative efficacy and safety fractionated (FSRT) single-session radiosurgery (SRS) scarce. Methods: Longitudinal volumetric analysis was performed in a consecutive cohort 120 patients 190 (>0.065 cm³ volume / >~5 mm diameter) treated exclusively with FSRT (n=98) SRS (n=92), respectively. A total 972 tumor segmentations used, averaging 5.1 time points per metastasis. Progression defined...
Purpose The first aim of the trial is to study feasibility combined programmed death protein ligand 1/cytotoxic T-lymphocyte-associated 4 inhibition concomitant radiotherapy. In addition, efficacy entire treatment scheme consisting induction chemoimmunotherapy followed by chemotherapy-free radioimmunotherapy (RIT) after intratumoral CD8 +immune cell-based patient selection will be analyzed. Methods Patients with stage III–IVB head and neck squamous cell carcinoma were eligible for this...
Abstract Background Promptable foundation auto-segmentation models like Segment Anything (SA, Meta AI, New York, USA) represent a novel class of universal deep learning that could be employed for interactive tumor auto-contouring in RT treatment planning. Methods was evaluated an point-to-mask task glioma brain 16,744 transverse slices from 369 MRI datasets (BraTS 2020 dataset). Up to nine point prompts were automatically placed per slice. Tumor boundaries auto-segmented on contrast-enhanced...
Abstract With the increasing use of innovative next generation sequencing (NGS) platforms in routine diagnostic and research settings, genetic landscape uterine sarcomas has been dynamically evolving during last two decades. Notably, majority recently recognized genotypes represent gene fusions, while recurrent oncogene mutations and/ or therapeutic value have rare. Recently, a distinctive aggressive sarcoma expressing S100 SOX10, but otherwise lacking morphological, immunophenotypic...
This research aims to improve glioblastoma survival prediction by integrating MR images, clinical, and molecular-pathologic data in a transformer-based deep learning model, addressing heterogeneity performance generalizability.
ABSTRACT Background The purpose of this study was to evaluate risk factors that influence overall survival (OS)/disease‐free (DFS)/locoregional recurrence‐free (LRFS), and distant metastases‐free (DMFS) in patients with high‐risk primary salivary gland carcinoma who underwent surgery postoperative (chemo)radiotherapy curative intention. Methods We reviewed data 63 a retrospective single‐center audit. Results At median follow‐up 31 months (range, 5–145 months), cumulative OS DFS were 91.7%,...
Chemotherapy with or without radiotherapy is the standard in patients initially nonmetastatic unresectable pancreatic cancer. Additional surgery discussion. The CONKO-007 multicenter randomized trial examines value of radiotherapy. Our interim analysis showed a significant effect surgery, which may be relevant to clinical practice.One hundred eighty received induction chemotherapy (gemcitabine FOLFIRINOX). Patients tumor progression were either alone concurrent chemoradiotherapy. At end...
Small blue round cell sarcomas (SBRCSs) are a heterogeneous group of tumors with overlapping morphologic features but markedly varying prognosis. They characterized by distinct chromosomal alterations, particularly rearrangements leading to gene fusions, whose detection currently represents the most reliable diagnostic marker. Ewing (ESs) common SBRCSs, defined fusions involving EWSR1 and transcription factors ETS family, while frequent non-EWSR1-rearranged SBRCSs harbor CIC rearrangement....
Background Current standard treatment concepts in head and neck squamous cell carcinoma (HNSCC) are based on former studies using 2D 3D plans. However, modern radiation techniques allow for a more precise individual dose application. Therefore, clearly defined patient population, de-intensified risk-adapted is investigated. Methods Patients with newly diagnosed HNSCC after surgery (with resection margins ≥1 mm cM0) the following tumor stages (TNM 7th Edition) were eligible study: oral...
Abstract Purpose The management of soft tissue sarcoma (STS) at reference centers with specialized multidisciplinary tumor boards (MTB) improves patient survival. German Cancer Society (DKG) certifies in German-speaking countries, promoting high standards care. This study investigated the variability treatment recommendations for localized STS across different tertiary centers. Methods In this cross-sectional case-based survey study, 5 anonymized cases imaging data were presented to MTBs 21...