A5040602619- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Inflammatory Biomarkers in Disease Prognosis
- Cardiac tumors and thrombi
- Bone Tumor Diagnosis and Treatments
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Cancer, Lipids, and Metabolism
- Pancreatitis Pathology and Treatment
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Testicular diseases and treatments
- Management of metastatic bone disease
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Soft tissue tumor case studies
- CAR-T cell therapy research
- Urologic and reproductive health conditions
- Epigenetics and DNA Methylation
- Venous Thromboembolism Diagnosis and Management
Medical University of Graz
2016-2025
University of Opole
2020-2022
Erasmus MC Cancer Institute
2020-2021
Graz University Hospital
2014
PharmacoGenetics (China)
2014
University of Graz
2009-2014
Taipei Institute of Pathology
2014
The neutrophil-lymphocyte ratio (NLR) has been proposed as an indicator of systemic inflammatory response. Previous findings from small-scale studies revealed conflicting results about its independent prognostic significance with regard to different clinical end points in pancreatic cancer (PC) patients. Therefore, the aim our study was external validation NLR a large cohort PC patients.Data 371 consecutive patients, treated between 2004 and 2010 at single centre, were evaluated...
Inflammation has a critical role in the pathogenesis and progression of cancer. The lymphocyte to monocyte ratio (LMR) could be shown prognostic haematologic neoplasia. In this study, we analysed LMR with clinical outcome stage II III colon cancer patients. Three hundred seventy-two patients were included retrospective study. Kaplan–Meier curves multivariate Cox-regression analyses calculated for time recurrence (TTR) overall survival (OS). Including all patients, elevated preoperative was...
Tertiary lymphoid structures (TLS) are associated with favorable outcome in non-metastatic colorectal carcinoma (nmCRC), but the dynamics of TLS maturation and its association effective anti-tumor immune surveillance nmCRC unclear. Here, we hypothesized that not only number also their composition harbors information on recurrence risk nmCRC. In a comprehensive molecular, tissue, laboratory, clinical analysis 109 patients stage II/III nmCRC, assessed numbers degree surgical specimens by...
Inflammation has a critical role in the pathogenesis and progression of cancer. Recently, derived neutrophil to lymphocyte ratio (absolute count neutrophils divided by absolute white cell minus neutrophils; dNLR) been shown influence clinical outcome various cancer entities. In this study, we analysed dNLR with stage II III colon patients. Three-hundred seventy-two patients were included retrospective study. Kaplan–Meier curves multivariate Cox proportion analyses calculated for time...
Recent evidence indicates that the host inflammatory response has an important role in tumour progression. Elevated C-reactive protein (CRP) levels have been previously associated with poor prognosis several cancer types including small-scale studies pancreatic (PC) patients. The purpose of present study was to validate prognostic impact plasma CRP at date diagnosis on cancer-specific survival (CSS) a large cohort PC Data from 474 consecutive patients adenocarcinoma pancreas, treated between...
Increasing evidence indicates the involvement of inflammation and coagulation in cancer progression metastases. Inflammatory biomarkers hold great promise for improving predictive ability existing prognostic tools patients. In present study, we investigated several inflammatory indices with regard to their relevance predicting clinical outcome soft tissue sarcoma (STS) Three hundred forty STS patients were divided into a training set (n = 170) validation 170). Besides well-established...
Recent data indicate that tumour microenvironment, which is influenced by inflammatory cells, has a crucial role in cancer progression and clinical outcome of patients. In the present study, we investigated prognostic relevance preoperative neutrophil/lymphocyte (N/L) ratio on time to recurrence (TTR) overall survival (OS) soft-tissue sarcoma (STS) patients who underwent curative surgical resection.In all, 260 STS were included this retrospective study. Kaplan-Meier curves multivariate Cox...
Fusions involving NTRK1, NTRK2, and NTRK3 are oncogenic drivers occurring in a spectrum of mesenchymal neoplasms ranging from benign to highly malignant tumors. To gain further insights into the staining profile with pan-TRK assay, we analyzed large number soft tissue sarcomas correlated our findings molecular testing. Additionally, expand NTRK-fusion tumors by reporting lesion lung as well skin fibrous histiocytoma NTRK-fusion. We retrospectively reviewed diagnosed at Diagnostic Research...
Introduction Since its introduction in November 2022, the artificial intelligence large language model ChatGPT has taken world by storm. Among other applications it can be used patients as a source of information on diseases and their treatments. However, little is known about quality sarcoma-related provides. We therefore aimed at analyzing how sarcoma experts evaluate ChatGPT’s responses inquiries assess bot’s answers specific evaluation metrics. Methods The to sample 25 questions (5...
Abstract Purpose The management of soft tissue sarcoma (STS) at reference centers with specialized multidisciplinary tumor boards (MTB) improves patient survival. German Cancer Society (DKG) certifies in German-speaking countries, promoting high standards care. This study investigated the variability treatment recommendations for localized STS across different tertiary centers. Methods In this cross-sectional case-based survey study, 5 anonymized cases imaging data were presented to MTBs 21...
With growing evidence on the role of inflammation in cancer biology, presence a systemic inflammatory response has been postulated as having prognostic significance wide range types. The derived neutrophil to lymphocyte ratio (dNLR), which represents an easily determinable potential marker daily practise and clinical trials, never externally validated pancreatic (PC) patients.Data from 474 consecutive PC patients, treated between 2004 2012 at single centre, were evaluated retrospectively....
The concept of the involvement systemic inflammation in cancer progression and metastases has gained attraction within past decade. C-reactive protein (CRP), a non-specific blood-based marker inflammatory response, been associated with decreased survival several types. aim present study was to validate prognostic value pre-operative plasma CRP levels on clinical outcome large cohort soft-tissue sarcoma (STS) patients.Three hundred four STS patients, operated between 1998 2010, were...
Unplanned excisions (UE) of soft tissue sarcomas (STS) carry a high risk for local recurrence (LR) due to marginal/intralesional resections. However, there are reports about improved prognosis UE patients who have re-resection compared with undergo planned surgery. The present multicentre study was designed define characteristics and investigate the impact on subsequent therapy patient outcomes. A total 728 STS (376 males, 352 females; mean age: 58 years) underwent definite surgery at one...
Intra-tumoral macrophages have been involved as important players in the pathogenesis and progression of cancer. Recently, inflammatory parameters systemic response also proposed usefully prognostic biomarkers. One these, lymphocyte to monocyte ratio (LMR) peripheral blood has shown a factor hematologic some solid tumors. In this study we analyzed for first time value LMR large middle European cohort pancreatic cancer (PC) patients.Data from 474 consecutive patients with ductal...
Prognostic nomograms for patients with extremity soft tissue sarcoma (eSTS) typically predict survival or the occurrence of local recurrence distant metastasis at time surgery. Our aim was to develop and externally validate a dynamic prognostic nomogram overall in eSTS survivors use during follow-up.All primary operated curative intent between 1994 2013 three European one Canadian centers formed development cohort. Patients Fédération Française des Centres de Lutte Contre le Cancer (FNCLCC)...
Metastatic testicular germ cell tumors (TGCTs) are a potentially curable disease by administration of risk-adapted cytotoxic chemotherapy. Nevertheless, disease-relapse after curative chemotherapy needs more intensive salvage and significantly worsens the prognosis TGCT patients. Circulating tumor markers (β-subunit human chorionic gonadotropin (β-HCG), alpha-Fetoprotein (AFP), Lactate Dehydrogenase (LDH)) frequently used for monitoring recurrence in patients, though they lack diagnostic...
The relatively low incidence and often atypical clinical presentation of soft-tissue sarcomas (STS) impedes early adequate diagnosis. Patients may report on recently enlarged swellings, infrequently complain painful lesions, or even have no symptoms at all.A thorough diagnostic work-up is essential in order to distinguish between benign tumours STSs. Patient history, features radiological findings all help assessing the underlying pathology. 'Worrying' such as recent increase size, deep...
Recently, chemical blood parameters gain more attraction as potential prognostic in pancreatic cancer (PC). In the present study we investigated relevance of uric acid (UA) level plasma at time diagnosis for overall survival (OS) a large cohort patients with PC.Data from 466 consecutive ductal adenocarcinoma pancreas were evaluated retrospectively. Overall was analysed using Kaplan-Meier method. To further evaluate significance UA level, univariate and multivariate Cox regression models...
Tumour markers including carcinoembryonic antigen (CEA) or carbohydrate 19-9 (CA19-9) are frequently determined at the time of diagnosis in patients with pancreatic cancer. Several studies indicate a prognostic relevance these cancer, but space for improvement regard to predictive accuracy and ability is given. In this work, main focus on mathematical combinations two tumour order validate an test results terms sensitivity specificity.This retrospective study includes 393 who were treated...