A5002050163- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Treatments and Studies
- Nutrition and Health in Aging
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Frailty in Older Adults
- Abdominal Trauma and Injuries
- Esophageal and GI Pathology
- Neuroblastoma Research and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Gastric Cancer Management and Outcomes
- Biliary and Gastrointestinal Fistulas
- Appendicitis Diagnosis and Management
- Radiomics and Machine Learning in Medical Imaging
- Hernia repair and management
- Gastrointestinal disorders and treatments
- Clinical Nutrition and Gastroenterology
- Cancer, Lipids, and Metabolism
Medical University of Graz
2015-2024
Universitätsklinik für Chirurgie Wien
2003-2024
Azienda Ospedaliera Universitaria Pisana
2022
Humanitas University
2021
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2017
Bayreuth Medical Center
2011
Memorial Sloan Kettering Cancer Center
2006-2010
University of California, Los Angeles
2007
VA Greater Los Angeles Healthcare System
2007
University Medical Center
2006
Resection of colorectal liver metastases (CLM) in selected patients has evolved as the standard care during last 20 years. In absence prospective randomized clinical trials, a survival benefit been deduced relative to historical controls based on actuarial data. There is now sufficient follow-up significant number address curative intent resecting CLM.Retrospective review prospectively maintained database was performed who underwent resection CLM from 1985 1994. Postoperative deaths were...
The neutrophil-lymphocyte ratio (NLR) has been proposed as an indicator of systemic inflammatory response. Previous findings from small-scale studies revealed conflicting results about its independent prognostic significance with regard to different clinical end points in pancreatic cancer (PC) patients. Therefore, the aim our study was external validation NLR a large cohort PC patients.Data 371 consecutive patients, treated between 2004 and 2010 at single centre, were evaluated...
Abstract BACKGROUND: Blood vessel invasion has been associated with poor outcome in colorectal cancer (CRC), whereas the prognostic impact of lymphatic is less clear. The authors this report evaluated venous and as potential indicators patients CRC focusing on lymph node‐negative compared routine review pathology diagnoses. METHODS: In total, 381 tumors from randomly selected were retrospectively reviewed. presence vascular was related to disease‐free cancer‐specific survival using...
The aim of this study was to determine the results liver resection for patients with bilateral hepatic metastases from colorectal cancer. We aimed assess evolution technical approach over time and correlations morbidity, mortality, oncologic outcome.Although isolated is thought be beneficial when feasible, carries unique issues often associated more aggressive tumor biology. Little has been written specifically about achieved in subset patients.Data a prospectively maintained database...
Recent evidence indicates that the host inflammatory response has an important role in tumour progression. Elevated C-reactive protein (CRP) levels have been previously associated with poor prognosis several cancer types including small-scale studies pancreatic (PC) patients. The purpose of present study was to validate prognostic impact plasma CRP at date diagnosis on cancer-specific survival (CSS) a large cohort PC Data from 474 consecutive patients adenocarcinoma pancreas, treated between...
Mucin glycoprotein expression can be altered during the carcinogenic process. The impact on prognosis of patients with colorectal cancer (CRC) is controversial. We analyzed tumors from 381 for MUC1, MUC2, MUC5AC, and MUC6 by immunohistochemical staining, using tissue microarrays. Progression-free cancer-specific survival were determined Kaplan-Meier method. Expression intestinal mucin MUC2 was lost in 85 (23 %) CRCs, MUC6-negative showed shorter progression-free (PFS, p = 0.043). Gastric...
Vertical tumor growth, reflected by T classification, represents the most important prognostic variable in colorectal cancer. Our study aimed to investigate impact of size, particularly maximum diameter, on outcome affected patients.A total 381 cancer specimens were re-evaluated. Tumor size and location extracted from medical history known for 359 patients (94%). Receiver-operator characteristic analysis was applied identify optimal (maximum sum sensitivity specificity) cut-off values with...
With growing evidence on the role of inflammation in cancer biology, presence a systemic inflammatory response has been postulated as having prognostic significance wide range types. The derived neutrophil to lymphocyte ratio (dNLR), which represents an easily determinable potential marker daily practise and clinical trials, never externally validated pancreatic (PC) patients.Data from 474 consecutive PC patients, treated between 2004 2012 at single centre, were evaluated retrospectively....
Intra-tumoral macrophages have been involved as important players in the pathogenesis and progression of cancer. Recently, inflammatory parameters systemic response also proposed usefully prognostic biomarkers. One these, lymphocyte to monocyte ratio (LMR) peripheral blood has shown a factor hematologic some solid tumors. In this study we analyzed for first time value LMR large middle European cohort pancreatic cancer (PC) patients.Data from 474 consecutive patients with ductal...
To analyse the prognostic impact of mucinous differentiation in colorectal adenocarcinomas and with a component. A total 381 tumours were reviewed for by two independent pathologists. Mismatch repair status was assessed immunohistochemistry. Prognostic significance univariate multivariate analyses. Eighty-one (21%) Union Internationale Contre le Cancer (UICC) Stage I, 120 (31%) II, 126 (33%) III 54 (14%) IV. Mucinous accounted 12% component 19% tumours. associated significantly mismatch...
SOX9 has been previously shown to be involved in hepatocellular carcinoma (HCC) and other types of cancer. However, prognostic studies so far rather small cohorts or lack external validation experimental data. In this study, we firstly determined the histological expression pattern human HCC by immunohistochemistry (n = 84) evaluated its value. External publicly available datasets were used validate relevance 359) cancer including breast 3951), ovarian 1306), lung 1926) gastric 876)....
The study aimed to analyze clinicopathological factors that determine the extent of lymph node retrieval and evaluate its prognostic impact in patients with colorectal cancer (CRC).The number retrieved nodes was analyzed 381 CRC specimens. Lymph count related different variables by binary logistic regression. Progression-free survival (PFS) cancer-specific (CSS) were determined using Kaplan-Meier method Cox regression models.The median 20 (mean 21 ± 10, range 1-65) right-sided, 13 (16 1-66)...
<h3>Importance</h3> In patients with resectable colorectal cancer liver metastases (CRLM), the choice of surgical technique and resection margin are only variables that under surgeon's direct control may influence oncologic outcomes. There is currently no consensus on optimal width. <h3>Objective</h3> To determine width in CRLM by using artificial intelligence–based techniques developed Massachusetts Institute Technology to assess whether should be individualized based patient...
Thermoablation, either cryosurgical ablation (CSA) or radiofrequency (RFA), combined with resection is effective in the treatment of extensive bilobar colorectal metastasis.Retrospective analysis a prospective hepatobiliary surgical database.Tertiary care referral center.Consecutive patients hepatic metastases selected for treatment.All underwent CSA RFA.Local recurrence rates at sites, overall survival, disease-free and survival.Between January 1, 1998, December 31, 2003, 665 resection. Of...
Recently, chemical blood parameters gain more attraction as potential prognostic in pancreatic cancer (PC). In the present study we investigated relevance of uric acid (UA) level plasma at time diagnosis for overall survival (OS) a large cohort patients with PC.Data from 466 consecutive ductal adenocarcinoma pancreas were evaluated retrospectively. Overall was analysed using Kaplan-Meier method. To further evaluate significance UA level, univariate and multivariate Cox regression models...
Tumour markers including carcinoembryonic antigen (CEA) or carbohydrate 19-9 (CA19-9) are frequently determined at the time of diagnosis in patients with pancreatic cancer. Several studies indicate a prognostic relevance these cancer, but space for improvement regard to predictive accuracy and ability is given. In this work, main focus on mathematical combinations two tumour order validate an test results terms sensitivity specificity.This retrospective study includes 393 who were treated...
Abstract Background The potential for a fibrin sealant patch to reduce the risk of postoperative pancreatic fistula (POPF) remains uncertain. aim this study was evaluate whether is able POPF in patients undergoing pancreatoduodenectomy with pancreatojejunostomy. Methods In multicentre trial, were randomized receive either (patch group) or no (control group), and stratified by gland texture, duct size neoadjuvant treatment. primary endpoint POPF. Secondary endpoints included complications,...