A5065485846- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Hemoglobin structure and function
- Colorectal Cancer Treatments and Studies
- Liver Disease Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Liver Disease and Transplantation
- Neuroendocrine Tumor Research Advances
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- Neonatal Health and Biochemistry
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Protein Structure and Dynamics
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Organ Transplantation Techniques and Outcomes
- Renal cell carcinoma treatment
- Mass Spectrometry Techniques and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Cells and Metastasis
Kumamoto University
2016-2025
Hôpital Paul-Brousse
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Université Paris-Saclay
2020-2024
Yokohama City University
2022
Kumamoto University Hospital
2022
The University of Texas MD Anderson Cancer Center
2020
Charité - Universitätsmedizin Berlin
2018
Johns Hopkins Medicine
2018
Johns Hopkins University
2018
In order to solve the problem of an apparent discrepancy between pH variance shape oxygen equilibrium curve and linear relation number released Bohr protons degree ligation, precise curves human hemoglobin were determined at a values from 6.5 8.8.From data individual constants for four oxygenation steps (Adair constants), ki (i = 1, 2, 3, 4), obtained (AH~+) on ith stage was estimated.The dependence k4 very small, while other ks strongly depended over range examined.As consequence,...
Inflammation and immune characteristics of the tumour microenvironment have therapeutic significance. The aim this study was to investigate clinical impact on disease progression in human extrahepatic cholangiocarcinoma (ECC). A total 114 consecutive ECC patients with curative resection between 2000 2014 were enrolled. Tumour infiltrating CD66b+ neutrophils (TANs; associated neutrophils), CD163+ M2 macrophages (TAMs; macrophages), CD8+ T cells, FOXP3+ regulatory cells (Tregs) assayed by...
Abstract Background Although associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been increasingly adopted by many centres, the oncological outcome colorectal metastases compared with that after two-stage is still unknown. Methods Between January 2010 June 2014, all consecutive patients who underwent either ALPPS or in a single institution were included study. Morbidity, mortality, disease recurrence survival compared. Results The two groups comparable...
The purpose of this study was to determine the optimal definition and elucidate predictive factors early recurrence after surgery for colorectal liver metastases (CRLM).Among 987 patients who underwent curative CRLM from 1990 2012, 846 with a minimum follow-up period 24 months were eligible study. p value approach survival initial used cutoff recurrence. prognostic analyzed.For 667 (79%) developed recurrence, point determined be 8 surgery. impact on demonstrated mainly in received...
Combining radiofrequency ablation (RFA) with hepatectomy may enable treatment curative intent for patients colorectal liver metastasis (CRLM). However, the oncological outcomes in comparison resection alone remain to be clarified.Patients who underwent a first between 2001 and 2012 CRLM were enrolled. Short- long-term of plus RFA compared those had using propensity score matching.Of total 553 patients, + performed 37 516 respectively. Before matching, group characterized primarily by larger...
Glycolysis is highly enhanced in Pancreatic ductal adenocarcinoma (PDAC) cells; thus, glucose restrictions are imposed on nontumor cells the PDAC tumor microenvironment (TME). However, little known about how such competition alters metabolism and confers phenotypic changes stromal TME. Here, we report that cancer-associated fibroblasts (CAFs) with restricted availability utilize lactate from glycolysis-enhanced cancer as a fuel exert immunosuppressive activity The expression of dehydrogenase...
Abstract Purpose: To establish cancer immunotherapy, it is important to identify the tumor-associated antigens (TAA) that are strongly expressed in tumor cells but not normal cells. In this study, an effective anticancer we tried useful TAA of pancreatic cancer. Experimental Design: Based on a previous genome-wide cDNA microarray analysis cancer, focused cadherin 3 (CDH3)/P-cadherin as novel candidate for immunotherapy. HLA-A2 (A*0201)–restricted CTL epitopes CDH3, used HLA-A2.1 (HHD)...
Precise oxygen equilibrium
Abstract Fusobacterium nucleatum has been detected in 8%‐13% of human colorectal cancer, and shown to inhibit immune responses against primary tumors animal models. Thus, we hypothesized that the presence F . might be associated with reduced T cell density cancer liver metastases (CRLM). We quantified DNA 181 CRLM specimens using quantitative PCR assay. The densities CD8 + cells, CD33 cells (marker for myeloid‐derived suppressor [MDSCs]), CD163 tumor‐associated macrophages [TAMs]) tissue...
Abstract Toward the development of a novel cancer immunotherapy, we have previously identified several tumor‐associated antigens (TAAs) and epitopes recognized by human histocompatibility leukocyte (HLA)‐A2/A24‐restricted cytotoxic T lymphocyte (CTL). In this study, tried to identify TAA lung (LC) its HLA‐A2 restricted CTL provide target antigen useful for immunotherapy LC. We testis antigen, cell division cycle associated gene 1 (CDCA1), overexpressed in nonsmall LC using cDNA microarray...
Identification of tumour-associated antigens (TAAs) that induce cytotoxic T lymphocytes (CTLs) specific to cancer cells is critical for the development anticancer immunotherapy. In this study, we aimed at identifying a novel TAA pancreatic On basis genome-wide cDNA microarray analysis, focused on KIF20A (also known as RAB6KIFL/MKlp2) candidate in cells. The HLA-A2 (A*02:01)-restricted CTL epitopes were identified using transgenic mice (Tgm) and peptides examined check whether they could...
Circulating tumour cells (CTCs) have an important role in metastatic processes, but details of their basic characteristics remain elusive. We hypothesised that CD44-expressing CTCs show a mesenchymal phenotype and high potential for survival hepatocellular carcinoma (HCC).Circulating CD44(+)CD90(+) cells, previously shown to be tumour-initiating were sorted from human blood genetic compared with those primary tissues. The mechanism underlying the circulatory system was investigated...
Immunotherapy using anti‐ PD ‐1/ ‐L1 antibodies for several types of cancer has received considerable attention in recent decades. However, the molecular mechanism underlying expression pancreatic ductal adenocarcinoma ( PDAC ) cells not been clearly elucidated. We investigated clinical significance and regulatory cells. Among various cytokines tested, tumor necrosis factor TNF )‐α upregulated through NF ‐κB signaling. The induction was also caused by co‐culture with activated macrophages,...
The aim of the study was to identify predictive factors failure 2-stage hepatectomy (TSH) for selection patients with extensive bilobar colorectal liver metastases (CRLM), who are candidates TSH.The main weakness TSH is risk complete both sequential procedures.Between 2000 and 2012, from a total cohort 845 resected CRLM, 125 (14.8%) CRLM were planned TSH. All related analyzed, model built utilizing independent failure.Forty-four (35.2%) could not proceed second stage, their overall survival...