Detlef Imhoff
A5032037681- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Management of metastatic bone disease
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
- Glioma Diagnosis and Treatment
- Diet and metabolism studies
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Brain Metastases and Treatment
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Medical Imaging and Analysis
- Radiation Therapy and Dosimetry
- Medical Imaging and Pathology Studies
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Pulmonary Hypertension Research and Treatments
- MRI in cancer diagnosis
- Tissue Engineering and Regenerative Medicine
- Nutrition, Genetics, and Disease
Goethe University Frankfurt
2014-2025
University Hospital Frankfurt
2004-2024
SAPHIR Radiochirurgie
2016-2023
Frankfurt Cancer Institute
2020
Deutschen Konsortium für Translationale Krebsforschung
2020
German Cancer Research Center
2020
Heidelberg University
2020
Klinikum Frankfurt Höchst
2017
Total neoadjuvant therapy has been increasingly adopted for multimodal rectal cancer treatment. The optimal sequence of chemoradiotherapy (CRT) and chemotherapy needs to be established. To report the long-term results secondary end points prespecified in Randomized Phase 2 Trial Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Neoadjuvant Therapy (CAO/ARO/AIO-12 trial) Locally Advanced Rectal Cancer. This analysis a randomized clinical trial included 311 patients who were...
The aim of this analysis was to model the effect local control (LC) on overall survival (OS) in patients treated with stereotactic body radiotherapy (SBRT) for liver or lung metastases from colorectal cancer.The is based pooled data two retrospective SBRT databases pulmonary and hepatic 27 centers Germany Switzerland. Only cancer were considered avoid histology as a confounding factor. An illness-death employed relationship between LC OS.Three hundred eighty-eight 500 metastatic lesions...
Chemotherapy with or without radiotherapy is the standard in patients initially nonmetastatic unresectable pancreatic cancer. Additional surgery discussion. The CONKO-007 multicenter randomized trial examines value of radiotherapy. Our interim analysis showed a significant effect surgery, which may be relevant to clinical practice.One hundred eighty received induction chemotherapy (gemcitabine FOLFIRINOX). Patients tumor progression were either alone concurrent chemoradiotherapy. At end...
Stereotactic radiosurgery (SRS) is the accurate, conformal delivery of high‐dose radiation to well‐defined targets while minimizing normal structure doses via steep dose gradients. While inverse treatment planning (ITP) with computerized optimization algorithms are routine, many aspects process remain user‐dependent. We performed an international, multi‐institutional benchmark trial study variability and analyze preferable ITP practice for spinal robotic radiosurgery. 10 SRS plans were...
We retrospectively evaluated the efficacy and toxicity of gross tumor volume (GTV) mean-dose-optimized real-time motion-compensated robotic stereotactic body radiation therapy (SBRT) in treatment liver metastases. Between March 2011 July 2015, 52 patients were treated with SBRT for a total 91 metastases (one to four per patient) median GTV 12 cc (min 1 cc, max 372 cc). The optimization mean dose was prioritized during planning at potential cost target (PTV) coverage reduction while adhering...
We retrospectively evaluated the efficacy and toxicity of gross tumor volume (GTV) mean dose optimized stereotactic body radiation therapy (SBRT) for primary secondary lung tumors with without robotic real-time motion compensation.Between 2011 2017, 208 patients were treated SBRT 111 163 metastases a median GTV 8.2 cc (0.3-174.0 cc). Monte Carlo optimization was performed prioritizing at potential cost planning target (PTV) coverage reduction while adhering to safe normal tissue constraints....
Background: The ERGO2 (Ernaehrungsumstellung bei Patienten mit Rezidiv eines Glioblastoms) MR-spectroscopic imaging (MRSI) subtrial investigated metabolism in patients randomized to calorically restricted ketogenic diet/intermittent fasting (crKD-IF) versus standard diet (SD) addition re-irradiation (RT) for recurrent malignant glioma. Intracerebral concentrations of ketone bodies (KB), intracellular pH (pHi), and adenosine triphosphate (ATP) were non-invasively determined. Methods: 50...
The aim of this study was to evaluate interobserver agreement (IOA) on target volume definition for pancreatic cancer (PACA) within the Radiosurgery and Stereotactic Radiotherapy Working Group German Society Radiation Oncology (DEGRO) identify influence imaging modalities volumes.Two cases locally advanced PACA one local recurrence were selected from a large SBRT database. Delineation based either planning 4D CT with or without (w/wo) IV contrast, w/wo PET/CT, diagnostic MRI. Novel compared...
For prostate cancer treatment, treatment options with minimal side effects are desired. External beam radiation therapy (EBRT) is non-invasive, standard of care and delivered in either conventional fractionation over 8 weeks or moderate hypo-fractionation about 5 weeks. Recent advances radiotherapy technology have made extreme hypo-fractionated stereotactic body (SBRT) feasible, which has not yet been introduced as a method Germany. Initial results from other countries promising, but...
Abstract Purpose We report results of the first German prospective multicenter single-arm phase II trial (ARO 2013-06; NCT02635256) hypofractionated robotic stereotactic body radiotherapy (SBRT) for patients with localized prostate cancer (HYPOSTAT). Methods Patients eligible HYPOSTAT study had (cT1‑3 cN0 cM0), Gleason score ≤ 7, prostate-specific antigen (PSA) 15 ng/ml, volume 80 cm 3 , and an International Prostate Symptom Score (IPSS) 12. Initially, inclusion was limited to ≥ 75 years or...
Abstract Purpose The present study comparatively evaluates the impact of energy-matched flattening filter-free (FFF) photon beams with different energy levels on physical-dosimetric quality lung and liver stereotactic body radiotherapy (SBRT) treatment plans. Methods For this purpose, 54 lesions from 44 patients who had already received SBRT combined volumetric modulated arc therapy (VMAT) were included in retrospective planning study. Planning computed tomography scans available used for...
Background: Spontaneous remission (SR) is the complete or incomplete disappearance of a disease cancer despite no inadequate treatment. SR rare event,and only 5 cases carcinoma uterine cervix have been reported so far. Case Report: We report case young woman suffering from metastasized to lung, pleura, bone,skin and brain. The primary tumor was removed. After diagnosis histologically proven metastases, further palliative treatment inadequate, except for radiotherapy In all other spontaneous...