A5008926152- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Neurological disorders and treatments
- Vascular Malformations Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Neurofibromatosis and Schwannoma Cases
- Radiation Dose and Imaging
- Advanced Neuroimaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Management of metastatic bone disease
- Radiation Therapy and Dosimetry
- Genetic Neurodegenerative Diseases
- Pituitary Gland Disorders and Treatments
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Head and Neck Surgical Oncology
- Medical Image Segmentation Techniques
- Radiopharmaceutical Chemistry and Applications
- Botulinum Toxin and Related Neurological Disorders
- MRI in cancer diagnosis
University Hospital Cologne
2015-2024
University of Cologne
2012-2024
LVR-Klinik Köln
2017-2018
Universitätsklinik für Stereotaktische Neurochirurgie
1993-2017
Stereotaxis (United States)
2011-2015
National Institute of Neurological Disorders and Stroke
2015
University of Virginia
2015
Centrum für Integrierte Onkologie
2014
Centre for Sight
2013
Fachkrankenhaus Hubertusburg
2013
ABSTRACT Objective The objective of this study was to investigate whether directional deep brain stimulation (DBS) the subthalamic nucleus in Parkinson's disease (PD) offers increased therapeutic windows, side‐effect thresholds, and clinical benefit. Methods In 10 patients, 20 monopolar reviews were conducted a prospective, randomized, double‐blind design identify best directions compare them conventional circular DBS regarding motor improvement, window. addition, best‐directional directly...
We treated a thirteen year old boy for life-threatening self-injurious behavior (SIB) and severe Kanner's autism with Deep Brain Stimulation (DBS) in the amygdaloid complex as well supra-amygdaloid projection system. Two DBS-electrodes were placed both structures of each hemisphere. The stimulation contacts targeted paralaminar, basolateral, central amygdala DBS was applied to these structures, but only baso-lateral part proved effective improving SIB core symptoms spectrum emotional, social...
Deep learning-based algorithms have demonstrated enormous performance in segmentation of medical images. We collected a dataset multiparametric MRI and contour data acquired for use radiosurgery, to evaluate the deep convolutional neural networks (DCNN) automatic brain metastases (BM).A conventional U-Net (cU-Net), modified (moU-Net) trained only on BM smaller than 0.4 ml (sU-Net) were implemented. Performance was assessed separate test set employing sensitivity, specificity, average false...
Abstract Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation varying frequencies 1 to 3 years after implantation electrodes. STN induced significant worsening symptoms, especially akinesia, compared no and therapeutic (≥130 Hz). This finding indicates relevance synchronization PD. © 2004 Movement Disorder Society
OBJECTIVE: Long-term follow-up data were analyzed to assess the value of intracavitary irradiation with stereotactically applied β-emitting radioisotopes for treatment craniopharyngioma cysts. METHODS: Sixty-two 70 consecutive patients predominantly cystic craniopharyngiomas selected retrospective analysis. β-Emitting isotopes injected intracystically using a computed tomography-guided and computer-assisted three-dimensional stereotactic planning application system (cumulative dose inner...
To determine histological correlates of the variability glucose consumption in astrocytomas, authors performed positron emission tomography (PET) with 18F-2-fluoro-2-deoxy-D-glucose (FDG) and matched PET scans three-dimensionally computerized obtained a stereotactic frame before biopsy. Ten patients astrocytomas World Health Organization Grade 2 or 3 were studied; glioblastomas, oligodendrogliomas, oligoastrocytomas excluded from study to avoid any confounding effects different cell types...
<h3>Background</h3> High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor functions in those with Parkinson disease but may worsen frontal such as verbal fluency (VF). In contrast, low-frequency DBS leads to deterioration functions. It is not known whether STN also has an effect on <h3>Objective</h3> To examine contrast high-frequency a positive basis VF test results. <h3>Design</h3> A double-blind randomized crossover experiment compare performance 4...
Directional deep brain stimulation (DBS) allows steering the in an axial direction which offers greater flexibility programming. However, accurate anatomical visualization of lead orientation is required for interpreting observed effects and to guide programming.In this study we aimed develop test robust algorithm determining segmented electrodes based on standard postoperative CT imaging used DBS.Orientation angles directional leads (CartesiaTM; Boston Scientific, Marlborough, MA, USA) were...
Purpose Orientating the angle of directional leads for deep brain stimulation ( DBS ) in an axial plane introduces a new degree freedom that is indicated by embedded anisotropic markers. Our aim was to develop algorithms determine lead orientation angles from computed tomography CT and stereotactic x‐ray imaging using standard clinical protocols, subsequently assess accuracy both methods. Methods In marker artifact taken as signature analyzed discrete Fourier transform circular intensity...
Resection is generally considered the gold standard for treatment of low-grade (WHO grades I and II) gliomas (LGGs) in childhood. However, approximately 30% to 50% these tumors are inoperable because their localization highly eloquent brain areas. A few reports have suggested stereotactic brachytherapy (SBT) with implantation iodine-125 ((125)I) seeds as a safe effective local alternative. This single-center study provides summary long-term outcome after SBT one largest reported patient...
Open questions remain regarding the optimal target, or sweetspot, for deep brain stimulation (DBS) in, example, Parkinson's disease. Previous studies introduced different methods of mapping DBS effects to determine sweetspots. While having a direct impact on surgical targeting and postoperative programming in DBS, these so far have not been compared.This study investigated five previously published approaches their potential correctly identify predefined target. Methods were silico eight...
This is a single case report of patient with spinocerebellar ataxia type 2 (SCA2) and severe tremor. Whereas disease progression prevailing dysmetria was slow over the first symptomatic 6 years, months prior to operation were characterized by development severe, debilitating postural tremor rendering unable independently sit, stand, speak, or swallow. Deep brain stimulation (DBS) at subthalamic-thalamic electrode position almost completely arrested her The regained functional state rapid...
Background: The spinothalamocortical tract (STC) is seen as a neural responsible for or involved in the generation transmission of thalamic pain. Either thalamus itself posterior limb internal capsule (PLIC) are targets deep brain stimulation (DBS) patients with pain, but due to its low contrast, conventional MRI cannot visualize STC directly. Objectives: To show feasibility integrating diffusion tensor imaging-based tractography into stereotactic treatment planning identification an...
Forty-six patients with suspected brain tumors were investigated by positron emission tomography (PET). Using 11C-methionine PET, the spatial extent of increased uptake in gliomas was larger than that contrast enhancement on CT/ MR images 67% or same 33%. Ten 46 treated brachytherapy for low-grade also 18F-2-fIuorodeoxyglucose (FDG)-PET. One year after seed implantation, glucose metabolism had not changed, but decline methionine significant. In conclusion, PET may improve tumor delineation...