A5081489767- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Medical Imaging Techniques and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Brain Tumor Detection and Classification
- Vascular Malformations Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Digital Imaging for Blood Diseases
- Functional Brain Connectivity Studies
- Neurofibromatosis and Schwannoma Cases
- Radiopharmaceutical Chemistry and Applications
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Management of metastatic bone disease
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Neurobiology of Language and Bilingualism
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroblastoma Research and Treatments
- Advanced X-ray and CT Imaging
- Cancer Immunotherapy and Biomarkers
- Spinal Fractures and Fixation Techniques
- Cancer-related cognitive impairment studies
University of Cologne
2016-2025
University Hospital Cologne
2016-2025
Universitätsklinik für Stereotaktische Neurochirurgie
2013-2024
Integrated Oncology (United States)
2024
Klinikum Fulda
2024
Forschungszentrum Jülich
2024
University Medical Center Hamburg-Eppendorf
2024
Universität Hamburg
2024
Heidelberg University
2017
LVR-Klinik Köln
2017
Terminology to describe extent of resection in glioblastoma is inconsistent across clinical trials. A surgical classification system was previously proposed based upon residual contrast-enhancing (CE) tumor. We aimed (1) explore the prognostic utility and (2) define how much removed non-CE tumor translates into a survival benefit.The international RANO resect group retrospectively searched compiled databases from 7 neuro-oncological centers USA Europe for patients with newly diagnosed per...
To evaluate an integrated battery of preoperative functional magnetic resonance imaging (fMRI) tasks developed to identify cortical areas associated with tactile, motor, language, and visual functions.Sensitivity each task was determined by the probability that a targeted region activated for both healthy volunteers (n = 63) surgical patients lesions in these critical 125). Accuracy correspondence between fMRI maps intraoperative electrophysiological measurements, including somatosensory...
The aim of this study was to investigate the potential <i>O</i>-(2-<sup>18</sup>F-fluoroethyl)-l-tyrosine (<sup>18</sup>F-FET) PET for differentiating local recurrent brain metastasis from radiation necrosis after therapy because use contrast-enhanced MRI issue is often difficult. <b>Methods:</b> Thirty-one patients (mean age ± SD, 53 11 y) with single or multiple contrast-enhancing lesions (<i>n</i> = 40) on metastases were investigated dynamic <sup>18</sup>F-FET PET. Maximum and mean...
The aim of this study was to investigate the potential combined textural feature analysis contrast-enhanced MRI (CE-MRI) and static O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET for differentiation between local recurrent brain metastasis radiation injury since CE-MRI often remains inconclusive. Fifty-two patients with new or progressive contrast-enhancing lesions on after radiotherapy (predominantly stereotactic radiosurgery) metastases were additionally investigated using FET PET. Based...
The aim of this study was to investigate the potential dynamic O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) PET for differentiating local recurrent brain metastasis from radiation injury after radiotherapy since contrast-enhanced MRI often remains inconclusive.Sixty-two patients (mean age, 55 ± 11 y) with single or multiple contrast-enhancing lesions (n = 76) on metastases (predominantly stereotactic radiosurgery) were investigated 18F-FET PET. Maximum and mean tumor-to-brain ratios (TBRmax,...
In patients with low-grade glioma (LGG) of World Health Organization (WHO) grade II, early detection progression to WHO III or IV is high clinical importance because the initiation a specific treatment depends mainly on grade. significant number LGG, however, information tumor activity and malignant cannot be obtained basis conventional MR imaging findings only. We here investigated potential O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET noninvasively detect in LGG.Twenty-seven (mean...
Deep learning-based algorithms have demonstrated enormous performance in segmentation of medical images. We collected a dataset multiparametric MRI and contour data acquired for use radiosurgery, to evaluate the deep convolutional neural networks (DCNN) automatic brain metastases (BM).A conventional U-Net (cU-Net), modified (moU-Net) trained only on BM smaller than 0.4 ml (sU-Net) were implemented. Performance was assessed separate test set employing sensitivity, specificity, average false...
Abstract Accurate Magnetic Resonance Imaging (MRI) simulation is fundamental for high-precision stereotactic radiosurgery and fractionated radiotherapy, collectively referred to as radiotherapy (SRT), deliver doses of high biological effectiveness well-defined cranial targets. Multiple MRI hardware related factors well scanner configuration sequence protocol parameters can affect the imaging accuracy need be optimized special purpose treatment planning. SRT possible different organizational...
OBJECTIVE There is a lack of data regarding the benefit-risk ratio and therapeutic value brain biopsy in very elderly patients with tumors. This study aimed to evaluate safety stereotactic aged ≥ 80 years assess impact procedure on subsequent management overall survival (OS). METHODS The authors retrospectively analyzed medical records all who underwent for newly diagnosed intracerebral tumor during 15-year period at single institution. RESULTS During period, 2350 biopsies were performed,...
This prospective longitudinally designed study was conducted to evaluate language functions pre- and postoperatively in patients who underwent microsurgical treatment of tumors close proximity or within areas detect those at risk for a postoperative aphasic disturbance.Between 1991 2005, 153 awake craniotomies with subsequent cortical mapping were performed 149 patients. Language assessed using standardized test battery. Risk factors obtained from multivariate logistic regression...
Abstract Determining the presence of tumor in biopsies and decision-making during resections is often dependent on intraoperative rapid frozen-section histopathology. Recently, stimulated Raman scattering microscopy has been introduced to rapidly generate digital hematoxylin-and-eosin-stained-like images (stimulated histology) for analysis. To enable prediction presence, we aimed develop a new deep residual convolutional neural network an automated pipeline tested its validity. In...
Background Traumatic brain injury (TBI) induces an acute inflammatory response characterized by early recruitment of cells (white blood cells). Rapid resuscitation TBI with hypertonic saline/dextran (HS/DEX) yields promising results in clinical and experimental studies. The purpose this paper was to test the hypothesis that HS/DEX exerts its effects part through a modulation TBI. Methods Rabbits equipped chronic cranial windows underwent fluid-percussion were followed up for 6 hours....
Functional magnetic resonance imaging (fMRI) in pediatric patients presents a unique set of problems due to the need for patient compliance, frequent sedation and an early developmental status. A new method using fMRI sedated infants young children is presented passive stimuli focused on visual, sensorimotor language functions. All these are such that no interaction required. Eight undergoing diagnostic MRI scans brain participated procedures. Cortical regions were identified standard...
Resection is generally considered the gold standard for treatment of low-grade (WHO grades I and II) gliomas (LGGs) in childhood. However, approximately 30% to 50% these tumors are inoperable because their localization highly eloquent brain areas. A few reports have suggested stereotactic brachytherapy (SBT) with implantation iodine-125 ((125)I) seeds as a safe effective local alternative. This single-center study provides summary long-term outcome after SBT one largest reported patient...
(1) Background: Transient increase in volume of vestibular schwannomas (VS) after stereotactic radiosurgery (SRS) is common and complicates differentiation between treatment-related changes (pseudoprogression, PP) tumor recurrence (progressive disease, PD). (2) Methods: Patients with unilateral VS (n = 63) underwent single fraction robotic-guided SRS. Volume were classified according to existing RANO criteria. A new response type, PP, a >20% transient was defined divided into early...
Although the correspondence between functional-magnetic resonance imaging (fMRI) representations of sensorimotor cortex and intraoperative electrophysiology (including somatosensory evoked potential, SSEP, recordings direct cortical stimulation) has been reported, a similar fMRI localization language-sensitive is not as well established. The aim present study was to evaluate concordance with respect cortices. We results 21 patients who underwent language mapping by including SSEP (n = 21),...