A5036219220- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- MRI in cancer diagnosis
- Criminal Law and Policy
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Advanced NMR Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Advanced Neuroimaging Techniques and Applications
- Ultrasound Imaging and Elastography
- Laser-Matter Interactions and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Renal and Vascular Pathologies
- Orbital Angular Momentum in Optics
- Electron Spin Resonance Studies
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Advanced Fiber Laser Technologies
- Prostate Cancer Diagnosis and Treatment
- NMR spectroscopy and applications
- Nuclear Physics and Applications
- Prostate Cancer Treatment and Research
- Medical and Health Sciences Research
German Cancer Research Center
2013-2025
University Medical Center Freiburg
2016-2025
University of Freiburg
2016-2025
University Hospital Heidelberg
1999-2025
Heidelberg University
2010-2025
Deutschen Konsortium für Translationale Krebsforschung
2015-2024
Bernstein Center for Computational Neuroscience Heidelberg-Mannheim
2023
Max-Born-Institute for Nonlinear Optics and Short Pulse Spectroscopy
2009-2022
MathWorks (United States)
2022
Centre for Biomedical Engineering and Physics
2021
Abstract Angiogenesis is essential for the development of malignant tumors and provides important targets tumor diagnosis therapy. To noninvasively assess angiogenic profile tumors, novel αvβ3 integrin–targeted ultrasmall superparamagnetic iron oxide particles (USPIOs) were designed their specific uptake by endothelial cells was evaluated in vitro vivo. USPIOs coated with 3-aminopropyltrimethoxysilane (APTMS) conjugated Arg-Gly-Asp (RGD) peptides. Accumulation human umbilical vein (HUVECs)...
Proton magnetic resonance imaging (MRI) has recently emerged as a clinical tool to image the lungs. This paper outlines current technical aspects of MRI pulse sequences, radiofrequency (RF) coils and system requirements needed for pulmonary parenchyma vasculature. Lung techniques are presented "technical toolkit", from which MR protocols will be composed in subsequent papers comprehensive lung disease function (parts 2 3). is pitched at scientists, technicians radiologists who interested...
Metabolic magnetic resonance imaging (MRI) using hyperpolarized (HP) pyruvate is becoming a non-invasive technique for diagnosing, staging, and monitoring response to treatment in cancer other diseases. The clinically established method producing HP pyruvate, dissolution dynamic nuclear polarization, however, rather complex slow. Signal Amplification By Reversible Exchange (SABRE) an ultra-fast low-cost based on fast chemical exchange. Here, the first time, we demonstrate not only vivo...
Internalization of Listeria monocytogenes into nonphagocytic cell lines in vitro requires the products inlAB locus (J.-L. Gaillard, P. Berche, C. Frehel, E. Gouin, and Cossart, Cell 65:1127-1141, 1991). By generating isogenic mutants with a chromosomal in-frame deletion either inlA or inlB, we have identified InlA InlB as surface-bound proteins L. molecular weights 88,000 65,000, respectively. These results were obtained monoclonal antibodies raised against protein corroborated by N-terminal...
Monitoring advanced malignant melanoma, serum levels of S100-beta (S100beta) and melanoma-inhibiting activity (MIA) were assessed for the ability to discriminate progressive from nonprogressive disease. S100beta MIA supposed be superior conventional variables, such as lactate dehydrogenase (LDH) level.Seventy-one patients with stage IV melanoma according criteria American Joint Committee on Cancer (AJCC) included in study. Results restaging examinations used an independent reference standard...
Abstract Arterial spin labeling (ASL) permits quantification of tissue perfusion without the use MR contrast agents. With standard ASL techniques such as flow‐sensitive alternating inversion recovery (FAIR) signal from arterial blood is measured at a fixed delay after magnetic labeling. As no image information sampled during this delay, FAIR measurements are inefficient and time‐consuming. In work preparation was combined with Look‐Locker acquisition to sample not one but series images each...
This report describes the development of a robotic assistance system that provides precise and reproducible instrument positioning inside MRI or CT gantry on basis processed imagery. Percutaneous interventions such as MRI-guided insertion cannulae probes for biopsy, drainage, drug delivery, energetic tumor destruction were primary drivers in design. Applications involving central nervous have been excluded because demanding medical device regulations approval process. The developed received...
Abstract 23 Na MRI has the potential to noninvasively detect sodium (Na) content changes in vivo. The goal of this study was implement a clinical setting for neurooncological and muscular imaging. Due biexponential T 2 decay tissue signal with short component, which ranges between 0.5–8 ms, measurement total requires imaging techniques echo times (TEs) below 0.5 ms. A 3D radial pulse sequence TE 0.2 ms at spatial resolution 4 × mm 3 developed that allows acquisition presentation images on...
The exact detection and delineation of the intraprostatic tumour burden is crucial for treatment planning in primary prostate cancer (PCa). We compared 68Ga-HBED-CC-PSMA PET/CT with multiparametric MRI (mpMRI) diagnosis patients PCa based on slice by correlation histopathological reference material.Seven histopathologically proven underwent followed radical prostatectomy. Resected prostates were scanned ex-vivo CT a special localizer prepared histopathology. Invasive was delineated HE...
Currently, the gold standard for dental imaging is projection radiography or cone-beam computed tomography (CBCT). These methods are fast and cost-efficient, but exhibit poor soft tissue contrast expose patient to ionizing radiation (X-rays). The need an alternative modality e.g. management has stimulated a rising interest in magnetic resonance (MRI) which provides superior contrast. Compared X-ray imaging, however, so far spatial resolution of MRI lower scan time longer. In this...
Carbon-13 hyperpolarized pyruvate is about to become the next-generation contrast agent for molecular magnetic resonance imaging of cancer and other diseases. Here, efficient rapid hyperpolarization achieved via signal amplification by reversible exchange (SABRE) with parahydrogen through synergistic use substrate deuteration, alternating, static microtesla fields. Up 22 6% long-lasting 13C polarization (T1 = 3.7 ± 0.25 1.7 0.1 min) demonstrated C1 C2 nuclear sites, respectively. The...
Abstract Accurate Magnetic Resonance Imaging (MRI) simulation is fundamental for high-precision stereotactic radiosurgery and fractionated radiotherapy, collectively referred to as radiotherapy (SRT), deliver doses of high biological effectiveness well-defined cranial targets. Multiple MRI hardware related factors well scanner configuration sequence protocol parameters can affect the imaging accuracy need be optimized special purpose treatment planning. SRT possible different organizational...
Journal Article Occupational skin disease in the construction industry Get access M. Bock, Bock Department of Clinical Social Medicine, Centre and Environmental Dermatology, University Heidelberg, Thibautstr. 3, D‐69115 Germany *Consultant Juvenellestr. 45, D‐90419 Nuremberg, Search for other works by this author on: Oxford Academic Google Scholar A. Schmidt, Schmidt T. Bruckner, Bruckner T.L. Diepgen Thomas L. Diepgen. E‐mail: Thomas_Diepgen@med.uni‐heidelberg.de British Volume 149, Issue...
Objective: To evaluate the accuracy of multidetector computed tomography (CT) and magnetic resonance imaging (MRI) in staging estimating renal carcinomas with caval thrombus. Methods: Initially, 23 patients suspected thrombi were admitted into this prospective study. Triphasic CT was performed using a reconstructed slice thickness 2 mm. 3D reconstructions used to improve surgical planning. MRI protocol included: transversal T1-weighted GE sequence without Gd-DTPA, T2-weighted...
Abstract The nuclear spin polarization of noble gases can be enhanced strongly by laser optical pumping followed electron‐nuclear transfer. Direct metastable 3 He atoms has been shown to produce enormous on the order 0.4–0.6. This is about 10 5 times larger than water protons at thermal equilibrium used in conventional MRI. We demonstrate that hyper‐polarized gas applied magnetic resonance imaging organs with air‐filled spaces humans. In vivo MR experiments were performed a whole‐body...
To analyze the blood flow dynamics in renal artery stenosis with high-temporal-resolution cine phase-contrast magnetic resonance (MR) measurements.Cine MR measurements were invasively validated real-time intraoperative transit-time ultrasound (US). In 23 patients, 48 stenoses confirmed at digital subtraction angiography. Cardiac-gated obtained 32-msec intervals, and curves calculated for whole cardiac cycle. Hemodynamic parameters evaluated included decrease mean delay reduction systolic...
AbstractObjective: A variety of medical robots have been developed in recent years. MRI, including MR angiography and morphological imaging, with its excellent soft-tissue contrast is attractive for the development interventional MRI-guided therapies operations. This paper presents a telerobotic device use CT- and/or MR-guided radiological interventions. robotic precise needle insertion during therapy spinal diseases will be briefly described.Materials Methods: Actuation an MRI environment...
To compare two different three-dimensional (3D) gadolinium-enhanced magnetic resonance (MR) angiographic techniques.In 26 patients suspected of having renal artery stenosis, results with fast multiphase 3D MR angiography were compared to those standard in 37 patients. With both techniques, 31-second breath-hold acquisitions performed. Multiphase comprised five discrete 6.4-second without bolus timing, and a single acquisition based on test-bolus timing. Two readers evaluated images obtained...
The aim of this pilot-study was to evaluate changes in myocardial oxygenation and perfusion under pharmacological stress with dipyridamole (DIP) by means MRI. Twenty healthy volunteers were examined using a multi-echo gradient-echo sequence. differential signal response due the blood oxygen level dependent (BOLD) effect studied variable conditions supply caused vasodilator DIP. Unlike contrast agents (CA) methods, which require at least two injections CA DIP, presented methods only single...
In chronic atrial fibrillation (cAF) the potassium current IK,ACh develops agonist-independent constitutive activity. We hypothesized that abnormal phosphorylation-dependent regulation underlies activity.We used voltage-clamp technique and biochemical assays to study in appendages from 61 sinus rhythm (SR), 11 paroxysmal AF (pAF), 33 cAF patients.Compared SR basal was higher only, whereas muscarinic receptor (2 micromol/L carbachol)-activated smaller pAF cAF. selective blocker tertiapin...
Objectives: Total tissue sodium (23Na) content is associated with the viability of cells and can be assessed by 23Na magnetic resonance imaging. However, resulting total signal (23NaT) represents a volume-weighted average different compartments assigned to intra- extracellular space. In addition spin-density weighted contrast 23NaT imaging, relaxation-weighted (23NaR) sequences were applied. The aim this study was evaluate potential 23NaR imaging for characterization putative additional...