A5017656329- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Glioma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Muscle Physiology and Disorders
- Autoimmune Bullous Skin Diseases
- Genetic Syndromes and Imprinting
- Urticaria and Related Conditions
- RNA regulation and disease
- Neurogenetic and Muscular Disorders Research
- Genital Health and Disease
- Lymphatic System and Diseases
- Oral Health Pathology and Treatment
- Acute Lymphoblastic Leukemia research
- Blood disorders and treatments
- Metabolism and Genetic Disorders
- Glycogen Storage Diseases and Myoclonus
- Cardiomyopathy and Myosin Studies
- Skin Diseases and Diabetes
- Cytomegalovirus and herpesvirus research
- Peripheral Neuropathies and Disorders
University of Cologne
2010-2023
University Hospital Cologne
2014-2023
Matrix Research (United States)
2019
Kiel University
2016
University of Bonn
1999-2004
Centrum für Integrierte Onkologie
2003
University Hospital Bonn
2001
Goethe University Frankfurt
1999
Alterations in the DNA methylation pattern are a hallmark of leukemias and lymphomas. However, most epigenetic studies hematologic neoplasms (HNs) have focused either on analysis few candidate genes or many HN entities, comprehensive required.Here, we report for first time microarray-based study 767 367 HNs diagnosed with 16 representative B-cell (n = 203), T-cell 30), myeloid 134) neoplasias, as well 37 samples from different cell types hematopoietic system. Using appropriate controls B-,...
Abstract Chronic lymphocytic leukemia (CLL) remains an incurable disease. Two recurrent cytogenetic aberrations, namely del(17p), affecting TP53 , and del(11q), ATM are associated with resistance against genotoxic chemotherapy (del17p) poor outcome (del11q del17p). Both del(17p) del(11q) also inferior to the novel targeted agents, such as BTK inhibitor ibrutinib. Thus, even in era of therapies, CLL alterations ATM/p53 pathway a clinical challenge. Here we generated two mouse models Atm -...
Abstract Background The BRAF V600E mutation is present in approximately 50% of patients with melanoma brain metastases and an important prerequisite for response to targeted therapies, particularly inhibitors. As heterogeneity terms status may occur patients, a wild-type extracranial primary tumor does not necessarily rule out targetable using We evaluated the potential MRI radiomics noninvasive prediction intracranial status. Methods Fifty-nine from two university centers (group 1, 45...
Primary central nervous system lymphomas (PCNSLs) are germinal center-derived diffuse large B-cell (DLBCLs) arising in and remaining confined to the brain, pathogenesis of which is poorly understood. We investigated 13 PCNSLs from immunocompetent patients by means interphase cytogenetics on cryopreserved cells derived stereotactic biopsies. Interphase fluorescence situ hybridization (FISH) was performed for detection structural alterations affecting IGH (14q32), IGK (2p12), IGL (22q11), BCL6...
ABSTRACT To analyze the role of interleukin-10 (IL-10) in bacterial cerebral infections, we studied listeriosis IL-10-deficient (IL-10 −/− ) and wild-type (WT) mice, latter which express high levels IL-10 both primary secondary listeriosis. mice succumbed to as well listeriosis, whereas WT were significantly protected from by prior intraperitoneal immunization with Listeria monocytogenes . Meningoencephalitis developed strains; however, inflammation was more severe associated increased brain...
Primary lymphomas of the CNS (PCNSLs) show molecular features late germinal center exit B-cell phenotype and are impaired in their terminal differentiation as indicated by a lack immunoglobulin class switching. Because positive regulatory domain I protein with ZNF (PRDM1/BLIMP1) is master regulator into plasma cells, we investigated series 21 PCNSLs for presence mutations PRDM1 gene alterations expression pattern protein. Direct sequencing all coding exons identified deleterious associated...