A5078406508- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Nonlinear Dynamics and Pattern Formation
- Photoreceptor and optogenetics research
- stochastic dynamics and bifurcation
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced Memory and Neural Computing
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Hearing Loss and Rehabilitation
- Genetic Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Chaos control and synchronization
- Neuroscience and Neuropharmacology Research
- Mechanical and Optical Resonators
- Vestibular and auditory disorders
- Neural Networks and Applications
- Complex Systems and Time Series Analysis
- Molecular Communication and Nanonetworks
- Atomic and Subatomic Physics Research
- Slime Mold and Myxomycetes Research
- Visual perception and processing mechanisms
Stanford University
2016-2025
Stanford Medicine
2022
Forschungszentrum Jülich
2009-2020
Center for Physical Sciences and Technology
2017-2020
Institute for Research in Fundamental Sciences
2018
Institute for Advanced Studies in Basic Sciences
2018
University of Cologne
2008-2017
University of Stuttgart
1995-2014
University Hospital Cologne
2003-2013
Google (United States)
2012
We use the concept of phase synchronization for analysis noisy nonstationary bivariate data. Phase is understood in a statistical sense as an existence preferred values difference, and two techniques are proposed reliable detection synchronous epochs. These methods applied to magnetoencephalograms records muscle activity Parkinsonian patient. reveal that temporal evolution peripheral tremor rhythms directly reflects time course abnormal between cortical motor areas.
Coordinated reset neuromodulation consists of the application consecutive brief high-frequency pulse trains through different contacts stimulation electrode. In theoretical studies, by achieving unlearning abnormal connectivity between neurons, coordinated reduces pathological synchronization, a hallmark feature Parkinson's disease pathophysiology. Here we show that subthalamic nucleus has both acute and sustained long-lasting aftereffects on motor function in parkinsonian nonhuman primates....
Purpose: Subjective tinnitus is associated with pathologic enhanced neuronal synchronization. We used a model based desynchronization technique, acoustic coordinated reset (CR) neuromodulation, to specifically counteract tinnitus-related syn
The discovery of abnormal synchronization neuronal activity in the basal ganglia Parkinson's disease (PD) has prompted development novel neuromodulation paradigms. Coordinated reset intends to specifically counteract excessive and induce cumulative unlearning pathological synaptic connectivity synchrony.In this prospective case series, six PD patients were evaluated before after coordinated according a standardized protocol that included both electrophysiological recordings clinical...
Magnetoencephalographic (MEG) and electromyographic (EMG) signals were recorded from six subjects during isometric contraction of four different muscles. Cortical sources located the MEG signal which was averaged time-locked to onset motor unit potentials. A spatial filtering algorithm used estimate source activity. Sources found in primary cortex (M1) contralateral contracted muscle. Significant coherence between rectified EMG M1 activity seen 20 Hz frequency range all subjects....
We show that nonlinear delayed feedback opens up novel means for the control of synchronization. In particular, we propose a demand-controlled method powerful desynchronization, which does not require any time-consuming calibration. Our technique distinguishes itself by its robustness against variations system parameters, even in strongly coupled ensembles oscillators. suggest our mild and effective deep brain stimulation neurological diseases characterized pathological cerebral
Chimera states are remarkable spatiotemporal patterns in which coherence coexists with incoherence. As yet, chimera have been considered as nongeneric, since they emerge only for particular initial conditions. In contrast, we show here that a network of globally coupled oscillators delayed feedback stimulation realistic (i.e., spatially decaying) profile generically induces states. Intriguingly, bifurcation analysis reveals these the natural link between coherent and incoherent
Purpose The development of therapeutic interventions for chronic tinnitus requires sensitive and clinically responsive tools to measure treatment-induced changes in loudness annoyance. In this study, the authors evaluated psychometric properties patient-reported visual analog scales (VAS) measuring subjectively perceived Method analyzed data from a single-blind, randomized, placebo-controlled study acoustic coordinated reset (CR) neuromodulation patients with (trial registration: “Randomized...
Standardized low-resolution brain electromagnetic tomography (sLORETA) is a widely used technique for source localization. However, this still has some limitations, especially under realistic noisy conditions and in the case of deep sources. To overcome these problems, we present here swLORETA, an improved version sLORETA, obtained by incorporating singular value decomposition-based lead field weighting. We show that precision localization can further be tomographic phase synchronization...
Coordinated reset (CR) stimulation is a desynchronizing technique based on timely coordinated phase resets of sub-populations synchronized neuronal ensemble. It has initially been computationally developed for electrical deep brain (DBS), to enable an effective desynchronization and unlearning pathological synchrony connectivity (anti-kindling). Here we show ensembles spiking bursting model neurons interacting via excitatory inhibitory adaptive synapses that populations as well anti-kindling...
Abstract Cravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients with the binge eating disorder (BED). In this pilot study, we used responsive deep brain stimulation (DBS) to record nucleus accumbens (NAc) electrophysiology during cravings preceding LOC two BED and severe obesity (trial registration no. NCT03868670). Increased NAc low-frequency oscillations, prominent cravings, were guide DBS delivery. Over 6 months, observed...
Adaptivity is a dynamical feature that omnipresent in nature, socio-economics, and technology. For example, adaptive couplings appear various real-world systems, such as the power grid, social, neural networks, they form backbone of closed-loop control strategies machine learning algorithms. In this article, we provide an interdisciplinary perspective on systems. We reflect notion terminology adaptivity different disciplines discuss which role plays for fields. highlight common open...
We present a simplified phase model for neuronal dynamics with spike timing-dependent plasticity (STDP). For asymmetric, experimentally observed STDP we find multistability: coexistence of fully synchronized, desynchronized, and variety cluster states in wide enough range the parameter space. show that multistability can occur only asymmetric STDP, study how synchronization desynchronization clustering depends on distribution eigenfrequencies. test efficacy proposed method Kuramoto which is,...