A5052937691- Prostate Cancer Treatment and Research
- Head and Neck Cancer Studies
- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Chromatin Remodeling and Cancer
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Brain Metastases and Treatment
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Urologic and reproductive health conditions
- Radiation Dose and Imaging
- Meningioma and schwannoma management
- MicroRNA in disease regulation
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Radiation Therapy and Dosimetry
- Advanced X-ray and CT Imaging
- Breast Cancer Treatment Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
Innsbruck Medical University
2017-2025
Universität Innsbruck
2018-2025
University Hospital Innsbruck
2021-2025
Helmholtz Zentrum München
2016-2024
Ludwig-Maximilians-Universität München
2013-2023
Heidelberg University
2016-2023
German Cancer Research Center
2017-2023
LMU Klinikum
2009-2023
Universitätsklinik für Strahlentherapie
2018-2023
Deutschen Konsortium für Translationale Krebsforschung
2017-2023
Radiomics applies machine learning algorithms to quantitative imaging data characterise the tumour phenotype and predict clinical outcome. For development of radiomics risk models, a variety different is available it not clear which one gives optimal results. Therefore, we assessed performance 11 combined with 12 feature selection methods by concordance index (C-Index), loco-regional control (LRC) overall survival for patients head neck squamous cell carcinoma. The considered are able deal...
The observation that human meningioma cells strongly express somatostatin receptor (SSTR 2) was the rationale to analyze retrospectively in how far DOTATOC PET/CT is helpful improve target volume delineation for intensity modulated radiotherapy (IMRT).In 26 consecutive patients with preferentially skull base meningioma, diagnostic magnetic resonance imaging (MRI) and planning-computed tomography (CT) complemented data from [(68)Ga]-DOTA-D Phe(1)-Tyr(3)-Octreotide (DOTATOC)-PET/CT. Image...
Purpose: Intensity modulated proton therapy (IMPT) of head and neck (H&N) cancer patients may be improved by plan adaptation. The decision to adapt the treatment based on a dose recalculation current anatomy requires diagnostic quality computed tomography (CT) scan patient. As gantry‐mounted cone beam CT (CBCT) scanners are currently being offered vendors, they offer daily or weekly updates patient anatomy. CBCT image not sufficient for accurate calculation it is likely necessary perform...
Purpose This work aims at investigating intensity corrected cone‐beam x‐ray computed tomography (CBCT) images for accurate dose calculation in adaptive modulated proton therapy (IMPT) prostate and head neck (H&N) cancer. A deformable image registration (DIR)‐based method a scatter correction approach using the data obtained from DIR as prior are characterized compared on basis of same clinical patient cohort first time. Methods Planning CT (pCT) daily CBCT (reconstructed measured...
Background. Adaptive intensity-modulated photon and proton radiotherapy (IMRT IMPT) of head neck (H&N) cancer requires frequent three-dimensional (3D) dose calculation. We compared two approaches for recalculation on the basis intensity-corrected cone-beam (CB) x-ray computed tomography (CT) images.
Although the organ preservation strategy by breast-conserving surgery (BCS) followed radiation therapy (BCT) has revolutionized treatment approach of early stage breast cancer (BC), choice between options in this setting can still vary according to patient preferences. The aim present study was compare oncological outcome mastectomy versus patients treated a modern clinical outside trials. 7565 women diagnosed with invasive BC (pT1/2pN0/1) 1998 and 2014 were included (median follow-up: 95.2...
Background and purposeFor skull base tumors, target definition is the key to safe high-dose treatments because surrounding normal tissues are very sensitive radiation. In present work we established a joint ESTRO ACROP guideline for volume of tumors.Material methodsA comprehensive literature search was conducted in PubMed using various combinations following medical subjects headings (MeSH) free-text words: "radiation therapy" or "stereotactic radiosurgery" "proton "particle beam "skull...
To evaluate the potential of (11)C-choline-positron emission tomography (PET)/computed (CT) for planning surgery in patients with prostate cancer and prostate-specific antigen (PSA) relapse after treatment curative intent.We retrospectively reviewed charts 10 PSA recurrence either external beam radiation (two) or radical retropubic prostatectomy (eight) cancer, who had a laparoscopic lymphadenectomy suspicious lymph nodes detected on (11)C-choline-PET/CT. The histological results PET/CT...
We examined the prognostic role of PD-1+ and CD8+ tumor infiltrating lymphocytes (TILs), PD-L1+ cells in patients with squamous cell carcinoma head neck (SCCHN) treated surgery postoperative chemoradiotherapy (CRT). FFPE samples from 161 were immunohistochemically stained for PD-1, CD8 PD-L1. The immune marker expression was correlated clinicopathologic characteristics, overall survival (OS), local progression-free (LPFS) distant metastases free-survival (DMFS), also context HPV16 DNA/p16...
A random walk model for intra-fraction motion has been proposed, where at each step the prostate moves a small amount from its current position in direction. Online tracking data perineal ultrasound is used to validate or reject this against alternatives. Intra-fraction of was recorded by 4D (Elekta Clarity system) during 84 fractions external beam radiotherapy six patients. In total, center tracked 8 h intervals 4 s. Maximum likelihood parameters were fitted data. The null hypothesis tested...
Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) detects prostate cancer recurrence at low PSA levels. Radiotherapy with dose escalation to the former bed has been associated improved biochemical recurrence-free survival (BRFS). Thus, we hypothesized that PSMA PET/CT-guided salvage radiotherapy leads BRFS. Methods: A total of 204 consecutive patients were referred for following radical prostatectomy. PET/CT scans performed and persistence (109...