A5104581149- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Molecular Biology Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Circular RNAs in diseases
- Ovarian cancer diagnosis and treatment
- Urological Disorders and Treatments
- Signaling Pathways in Disease
RWTH Aachen University
2011-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2024
Comprehensive Cancer Center Erlangen
2020-2024
Universitätsklinikum Erlangen
2015-2024
Universitätsklinikum Aachen
2014-2024
Goethe University Frankfurt
2024
University Hospital Frankfurt
2024
German Centre for Cardiovascular Research
2024
University of Cologne
2024
Karolinska University Hospital
2022
The infrequent association of serous borderline tumors (SBTs) with invasive carcinoma has led to the view that SBTs are unrelated carcinoma. Nonetheless, mortality associated is generally attributed malignant transformation, and traditionally these have been designated as "carcinomas low potential." Previous immunohistochemical studies evaluating p53 expression molecular genetic mutational status reported overexpression mutations in occur many 50% 80% carcinomas. different methodologies for...
n December 2019, an acute lung disease of unknown origin broke out in the Chinese province Hubei.On 7 January 2020, scientists succeeded isolating a new coronavirus (severe respiratory syndrome corona virus 2, SARS-CoV-2) and identifying it as cause virus-induced pneumonia (1, 2).In line with WHO's definition disease, is now referred to 2019 (COVID-19) and, person-to-person droplet infection, rapidly spreading worldwide (3).The clinical manifestation infection highly variable, ranging from...
Atypical EGFR mutations occur in 10%-30% of non-small-cell lung cancer (NSCLC) patients with and their sensitivity to classical epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) is highly heterogeneous. Patients harboring one group uncommon, recurrent (G719X, S768I, L861Q) respond EGFR-TKI. Exon 20 insertions are mostly insensitive EGFR-TKI but display exon inhibitors. Clinical outcome data very rare point compound upon systemic treatments still sparse date.In this...
To evaluate variant histologies (VHs) for disease-specific survival (DSS) in patients with invasive urothelial bladder cancer (BCa) undergoing radical cystectomy (RC).We analysed a multi-institutional cohort of 1082 treated upfront RC cT1-4aN0M0 BCa at eight centres. Univariable and multivariable Cox' regression analyses were used to assess the effect different VHs on DSS overall three stage-based analyses. The stages defined as 'organ-confined' (≤pT2N0), 'locally advanced' (pT3-4N0)...
Prostate cancer is a leading cause of tumor mortality. To characterize the underlying molecular mechanisms, we have compared microRNA (miRNA) profile primary prostate cancers and noncancer tissues using deep sequencing. MiRNAs are small noncoding RNAs 21 to 25 nucleotides that regulate gene expression through inhibition protein synthesis. We find 33 miRNAs were upregulated or downregulated >1.5-fold. The deregulation selected was confirmed by both Northern blotting quantitative reverse...
Aberrant activation of the Wnt signaling pathway plays an important role in development solid tumors such as breast and colon cancer. Secreted Frizzled-related protein 1 (SFRP1) is a negative regulator pathway. It has been described that SFRP1 mRNA strongly down-regulated cancer putative tumor suppressor function postulated. We have generated characterized specific antibody to analyze its expression on level investigate association with clinicopathological parameters patient survival....
Tumor-associated blood vessels differ from normal and proteins present only on tumor may serve as biomarkers or targets for antiangiogenic therapy in cancer. Comparing the transcriptional profiles of vascular endothelium human invasive bladder cancer with tissue, we found that endothelial cell-specific molecule endocan (ESM1) was highly elevated vessels. Endocan associated filopodia angiogenic tip cells Notably, expression correlated strongly staging invasiveness, predicting a shorter...
MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression via posttranscriptional inhibition of protein synthesis. They play a vital role in tumorigenesis. To characterize the diagnostic potential miRNAs prostate cancer, leading cause cancer mortality, we performed screening miRNA profiles. We used commercially available microarrays to establish profiles from cohort 20 samples. The selected was analyzed by quantitative real-time PCR and identity expressing cells determined...
Prostate carcinoma (CaP) is a leading cause of cancer-related death in men. We have previously determined the microRNA (miRNA) profile primary CaP comparison with nontumor prostate tissue. miRNAs are small, noncoding RNAs that inhibit protein synthesis on posttranscriptional level by binding to 3'-untranslated region (3'-UTR) their target genes. In tissue, we found miRNA sequencing miR-375 and miR-200c were upregulated 9.1- 4.5-fold, respectively. A computational analysis predicted 3'-UTR...
In primary prostate cancer (PCa), a major cause of cancer-related death in men, the expression various microRNAs (miRNAs) is deregulated. We previously detected several miRNAs, for example, miR-24 and miR-22, as significantly downregulated PCa (Szczyrba et al., Mol Cancer Res 2010;8:529-38). An silico search predicted that zinc finger protein 217 (ZNF217) importin 7 (IPO7) were potential target genes these miRNAs. Additionally, two are deregulated (heterogeneous nuclear ribonucleoprotein K,...
Incretin-based therapies, including glucagon-like peptide 1 (GLP-1) receptor agonists and dipeptidyl peptidase 4 (DPP-4) inhibitors, are potent glucose-lowering drugs. Still, only GLP-1 with close homology to (liraglutide semaglutide) but neither exenatide-based nor DPP-4 inhibitors were found reduce cardiovascular events. This different response might relate receptor-independent actions of caused by cleavage products liberated structure GLP-1. To test this hypothesis, we directly compared...
MammaTyper is a novel CE-marked in vitro diagnostic RT-qPCR assay which assigns routinely processed breast cancer specimens into the molecular subtypes Luminal A-like, B-like (HER2 positive or negative), HER2 (non-luminal) and Triple negative (ductal) according to mRNA expression of ERBB2, ESR1, PGR MKI67 St Gallen consensus surrogate clinical definition. Until now regarding formalin-fixed, paraffin-embedded material (FFPE), this has been task mostly accomplished by immunohistochemistry...
In non-small cell lung cancer (NSCLC), approximately 1-3% of cases harbor an increased gene copy number (GCN) the MET gene. This alteration can be due to de novo amplification or represent a secondary resistance mechanism in response targeted therapies. To date, gold standard method evaluate GCN is fluorescence situ hybridization (FISH). However, next-generation sequencing (NGS) becoming more relevant optimize therapy by revealing mutational profile each NSCLC. Using evaluable n = 205 NSCLC...
Small blue round cell sarcomas (SBRCSs) are a heterogeneous group of tumors with overlapping morphologic features but markedly varying prognosis. They characterized by distinct chromosomal alterations, particularly rearrangements leading to gene fusions, whose detection currently represents the most reliable diagnostic marker. Ewing (ESs) common SBRCSs, defined fusions involving EWSR1 and transcription factors ETS family, while frequent non-EWSR1-rearranged SBRCSs harbor CIC rearrangement....
Mass casualty incidents (MCIs) are events where the number of patients may exceed resources available for emergency management. In departments (ED), MCIs go along with high patient allocation in a short time period. For ED staff, simulation-based immersive scenario training can be an effective tool to develop communicative and leadership competencies manage these situations. A novel immersion experience was developed senior residents care. To our knowledge, this is first focusing on...
Sec62 is part of the protein translocation apparatus in membrane endoplasmic reticulum (ER). In yeast, participates post-translational proteins into ER, but its function mammals remains elusive. Previously we described amplification and over-expression SEC62 gene prostate cancer cell lines has been as a potential target cancer. current study show that tumor tissue patients levels are elevated compared with tumor-free derived from same or prostates control group higher content correlates an...