A5023371862- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Chronic Lymphocytic Leukemia Research
- Colorectal Cancer Treatments and Studies
- Cytokine Signaling Pathways and Interactions
- Mycobacterium research and diagnosis
- Gastrointestinal disorders and treatments
- Synthesis and biological activity
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Protein Degradation and Inhibitors
- Microtubule and mitosis dynamics
- Multiple Myeloma Research and Treatments
- Digestive system and related health
- T-cell and B-cell Immunology
- Fungal Plant Pathogen Control
- Gastrointestinal Tumor Research and Treatment
- Ubiquitin and proteasome pathways
- Eosinophilic Esophagitis
- Gene expression and cancer classification
University Cancer Center Hamburg
2021-2024
Universität Hamburg
2021-2024
University Medical Center Hamburg-Eppendorf
2021-2024
University of California, Irvine
2023-2024
Klinikum rechts der Isar
2007-2019
University Medical Center Freiburg
2014
Technical University of Munich
2009-2014
Atypical EGFR mutations occur in 10%-30% of non-small-cell lung cancer (NSCLC) patients with and their sensitivity to classical epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) is highly heterogeneous. Patients harboring one group uncommon, recurrent (G719X, S768I, L861Q) respond EGFR-TKI. Exon 20 insertions are mostly insensitive EGFR-TKI but display exon inhibitors. Clinical outcome data very rare point compound upon systemic treatments still sparse date.In this...
EGFR exon 20 (EGFR Ex20) insertion mutations in non-small cell lung cancer (NSCLC) are insensitive to traditional tyrosine kinase inhibitors (TKIs). Mobocertinib is the only approved TKI specifically designed target Ex20. We performed an international, real-world safety and efficacy analysis on patients with Ex20-positive NSCLC enrolled a mobocertinib early access program. explored mechanisms of resistance by analyzing postprogression biopsies, as well cross-resistance amivantamab. Data from...
Multiple myeloma (MM) is a plasma cell neoplasm that results from clonal expansion of an Ig-secreting terminally differentiated B cell. Advanced MM characterized by tissue damage involves bone, kidney, and other organs typically associated with recurrent genetic abnormalities. IL-6 signaling via the signal transducer GP130 has been implicated as important driver pathogenesis. Here, we demonstrated ectopic expression constitutively active (L-GP130) in murine retroviral...
Autophagy is a genetically regulated process of adaptation to metabolic stress and was recently shown be involved in the treatment response chronic myeloid leukemia (CML). However, vivo data are limited molecular mechanism autophagy regulators leukemogenesis not completely understood. Here we show that Beclin-1 knockdown, but Atg5 deletion murine CML model leads reduced leukemic burden results significantly prolonged median survival targeted mice. Further analyses cell lines primary patient...
Tyrosine-protein kinase (janus kinase; JAK)-signal transducer and activator of transcription (STAT) signaling plays a pivotal role in the development myeloproliferative neoplasms (MPNs). Treatment with potent JAK1/JAK2-specific inhibitor, ruxolitinib, significantly reduces tumor burden; however, ruxolitinib treatment does not fully eradicate malignant clone. As molecular basis for disease persistence is well understood, we set out to gain new insights by generating ruxolitinib-resistant cell...
9036 Background: The nNGM centralizes molecular diagnostics, treatment recommendations and follow-up reporting in NSCLC Germany. Uncommon EGFR mutations pose a clinical challenge because they comprise heterogenous group analyses of outcome are still scarce. Here, we analyzed data patients with rare performed functional characterization recurrent unknown function. Methods: This multicenter, retrospective analysis uncommon (excluding L858R-, T790M exon 19 deletions) includes stage IV from 12...
The NPM-ALK fusion kinase is expressed in 60% of systemic anaplastic large-cell lymphomas (ALCL). A Nuclear Interaction Partner ALK (NIPA) was identified as a binding partner NPM-ALK. To identify the precise role NIPA for NPM-ALK-driven lymphomagenesis, we investigated various + cell lines and mouse models. Nipa deletion primary embryonic fibroblasts resulted reduced transformation ability colony formation upon expression. Downregulating murine Ba/F3 human ALCL cells decreased their...
Introduction: Meckel's diverticulum (MD) is a rare congenital gastrointestinal (GI) anomaly that primarily affects children under 10 years old, but can also occur in adults, with higher risk observed men 50. While MD often remains clinically silent, it manifest as abdominal pain or varying degrees of GI bleeding. We present unique case severe bleeding and anemia secondary to 63-year-old woman. This report highlights occurrence an atypical demographic, the importance considering anomalies...
Introduction: While Celiac disease (CD) can occur with classical GI symptoms, more than half of patients CD do not show classic presentation and may even be asymptomatic. This case report describes an atypical only refractory osteopenia as the sole symptom. Case Description/Methods: A 62-year-old woman presented diagnosed in 2017. Alendronate treatment improved her L1-L4 bone mineral density (BMD) from a t-score -2.0 2017 to -1.6 2018, but despite same regimen, right hip BMD reduced -1.2...
Introduction: Gastrointestinal intussusception (GII) is a condition characterized by the telescoping of bowel tissue, 90% which in adults caused masses within bowel. Intussusception rare adults, accounting for less than 5% cases. GIIs primarily occur at ileo-colic junction, but may rarely present exclusively colon approximately 5%-10% In this case, we unique instance rectosigmoid (RSI) secondary to colorectal cancer an adult man. Understanding characteristics intussusception, particularly...
Introduction: De novo IBD is a rare complication following solid organ transplantation. Other post-transplant gastrointestinal complications like cytomegalovirus (CMV) colitis or mycophenolate mofetil (MMF) are more likely; therefore, de diagnosis of exclusion. Case Description/Methods: A 55-year-old man with history deceased donor kidney transplant in 2017, presented chronic diarrhea 2021. His maintenance immunosuppression included tacrolimus, MMF and prednisone. Stool studies for C....