A5000274456- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Nosocomial Infections in ICU
- Asthma and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Emergency and Acute Care Studies
- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Influenza Virus Research Studies
- Smoking Behavior and Cessation
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Lung Cancer Diagnosis and Treatment
- Delphi Technique in Research
- Mycobacterium research and diagnosis
- Pleural and Pulmonary Diseases
- Neonatal Respiratory Health Research
- COVID-19 and Mental Health
- Tuberculosis Research and Epidemiology
Goethe University Frankfurt
2013-2025
University Hospital Frankfurt
2017-2025
German Center for Lung Research
2015-2024
St. Elisabethen-Krankenhaus Frankfurt
2020-2024
Ophthalmology Clinic
2022
TU Dresden
2022
Universitätsklinik für Augenheilkunde
2022
University Hospital Carl Gustav Carus
2022
Vita-Salute San Raffaele University
2021
Medizinische Hochschule Hannover
2011-2020
Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent exacerbations many patients. There have been no previous international guidelines.The European Respiratory Society guidelines for the management adult bronchiectasis describe appropriate investigation treatment strategies determined by systematic review literature.A multidisciplinary group representing respiratory medicine, microbiology, physiotherapy, thoracic surgery, primary care, methodology...
<b>Background:</b> Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) are a common cause hospital admission. Many believed to be due upper and/or lower respiratory tract viral infections, but the incidence these infections in patients with COPD is still undetermined. <b>Methods:</b> Respiratory syncytial virus (RSV), influenza A and B, parainfluenza 3, picornaviruses were detected by nested reverse transcription polymerase chain reaction (RT-PCR) (nasal lavage) specimens...
There is broad interest in improved methods to generate robust evidence regarding best practice, especially settings where patient conditions are heterogenous and require multiple concomitant therapies. Here, we present the rationale design of a large, international trial that combines features adaptive platform trials with pragmatic point-of-care determine treatment strategies for patients admitted an intensive care unit severe community-acquired pneumonia. The uses novel design, entitled...
Appropriate isolation methods are essential for unravelling the relative contribution of extracellular vesicles (EVs) and EV-free secretome to homeostasis disease. We hypothesized that ultrafiltration followed by size exclusion chromatography (UF-SEC) provides well-matched concentrates EVs free secreted molecules proteomic functional studies. Conditioned media BEAS-2B bronchial epithelial cells were concentrated on 10 kDa centrifuge filters, separation protein using sepharose CL-4B SEC....
As of September 30, 2015, a total 1589 laboratory-confirmed cases infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to World Health Organization (WHO). At present there is no effective specific therapy against MERS-CoV. The use convalescent plasma (CP) has suggested as potential based on existing evidence from other viral infections. We aim study feasibility CP well its safety and clinical laboratory effects in critically ill patients MERS-CoV...
Bronchiectasis is one of the most neglected diseases in respiratory medicine. There are no approved therapies and few large-scale, representative epidemiological studies. The EMBARC (European Multicentre Audit Research Collaboration) registry a prospective, pan-European observational study patients with bronchiectasis. inclusion criterion primary clinical diagnosis bronchiectasis consisting of: 1) history consistent bronchiectasis; 2) computed tomography demonstrating Core exclusion criteria...
The present guideline provides a new and updated concept of treatment prevention adult patients with community-acquired pneumonia. It replaces the previous dating from 2009.The was worked out agreed on following standards methodology S3-guideline. This includes systematic literature search grading, structured discussion recommendations supported by as well declaration assessment potential conflicts interests.The has focus specific clinical circumstances, an update severity assessment, for...
Cirrhosis is known to have a high prevalence and mortality worldwide. However, in Europe, the epidemiology of cirrhosis possibly undergoing demographic changes, etiologies may changed due improvements standard care. The aim this population-based study was analyze trends course liver its complications recent years Germany.
Cardiac symptoms are increasingly recognized as late complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in previously well individuals with mild initial illness, but the underlying pathophysiology leading to long-term cardiac remains unclear. In this study, we conducted serial assessments a selected population Coronavirus Disease 2019 (COVID-19) no previous disease or notable comorbidities by measuring blood biomarkers heart injury dysfunction and...
Atypical EGFR mutations occur in 10%-30% of non-small-cell lung cancer (NSCLC) patients with and their sensitivity to classical epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) is highly heterogeneous. Patients harboring one group uncommon, recurrent (G719X, S768I, L861Q) respond EGFR-TKI. Exon 20 insertions are mostly insensitive EGFR-TKI but display exon inhibitors. Clinical outcome data very rare point compound upon systemic treatments still sparse date.In this...
Respiratory syncytial virus (RSV) burden in adults is underestimated mainly due to unspecific symptoms and limited standard-of-care testing. We estimated the population-based incidence of hospitalization mortality attributable RSV among with without risk factors Germany.
Respiratory viruses, predominantly rhinoviruses are the major cause of asthma exacerbations. Impaired production interferon-beta in rhinovirus infected bronchial epithelial cells (BECs) and newly discovered interferon-lambdas both BECs bronchoalveolar lavage cells, is implicated exacerbation pathogenesis. Thus replacement deficient interferon a candidate new therapy for Rhinoviruses other respiratory viruses infect macrophages, but their relative capacities alpha-, beta- lambda-interferon...
<b>Objective</b> To examine whether acute dysglycaemia predicts death in people admitted to hospital with community acquired pneumonia. <b>Design</b> Multicentre prospective cohort study. <b>Setting</b> Hospitals and private practices Germany, Switzerland, Austria. <b>Participants</b> 6891 patients pneumonia included the German competence network (CAPNETZ) study between 2003 2009. <b>Main outcome measures</b> Univariable multivariable hazard ratios adjusted for sex, age, current smoking...
<h3>Objective:</h3> To report safety and efficacy outcomes from up to 9 years of treatment with teriflunomide in an extension (NCT00803049) the pivotal phase 3 Teriflunomide Multiple Sclerosis Oral (TEMSO) trial (NCT00134563). <h3>Methods:</h3> A total 742 patients entered extension. Teriflunomide-treated continued original dose; those previously receiving placebo were randomized 1:1 14 mg or 7 mg. <h3>Results:</h3> By June 2013, median (maximum) exposure exceeded 190 (325) weeks per...
<h3>Objective</h3> To determine differences in aetiologies, initial antimicrobial treatment choices and outcomes patients with nursing-home-acquired pneumonia (NHAP) compared community-acquired (CAP), which is a controversial issue. <h3>Methods</h3> Data from the prospective multicentre Competence Network for Community-acquired (CAPNETZ) database were analysed hospitalised aged ≥65 years CAP or NHAP. Potential baseline characteristics, comorbidities, physical examination findings, severity...
Mycoplasma pneumoniae and Chlamydia spp., which are associated with community-acquired pneumonia (CAP), difficult to propagate, can cause clinically indistinguishable disease patterns. During 2011-2012, we used molecular methods test adult patients in Germany confirmed CAP for infection these 2 pathogens. Overall, 12.3% (96/783) of samples were positive M. 3.9% (31/794) spp.; C. psittaci (2.1%) was detected more frequently than (1.4%). P1 type 1 predominated, levels macrolide resistance low...
Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is the cause of current coronavirus disease 19 (COVID-19) pandemic. Protease inhibitors are under consideration as entry that prevent cleavage spike (S) protein by cellular proteases. Herein, we showed protease inhibitor aprotinin (but not SERPINA1/alpha-1 antitrypsin) inhibited SARS-CoV-2 replication in therapeutically achievable concentrations. An analysis proteomics and translatome data indicated associated with a downregulation host...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused a pandemic with tens of millions cases and hundreds thousands deaths. causes disease 2019 (COVID-19), the system divergent severity. In current study, humoral immune responses were characterized in cohort 143 patients COVID-19 from University Hospital Frankfurt am Main, Germany.SARS-CoV-2-specific-antibodies detected by enzyme-linked immunosorbent assay (ELISA). SARS-CoV-2 human NL63 neutralization activity...
Zusammenfassung Die vorliegende Leitlinie umfasst ein aktualisiertes Konzept der Behandlung und Prävention von erwachsenen Patienten mit ambulant erworbener Pneumonie löst die bisherige aus dem Jahre 2016 ab. Sie wurde entsprechend den Maßgaben zur Methodologie einer S3-Leitlinie erarbeitet verabschiedet. Hierzu gehören eine systematische Literaturrecherche -bewertung, strukturierte Diskussion Literatur begründbaren Empfehlungen sowie Offenlegung Bewertung möglicher Interessenskonflikte....