Mathias W. Pletz
A5065659547- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- Pneumocystis jirovecii pneumonia detection and treatment
- Sepsis Diagnosis and Treatment
- Influenza Virus Research Studies
- Infective Endocarditis Diagnosis and Management
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Bacterial biofilms and quorum sensing
- Cystic Fibrosis Research Advances
- Streptococcal Infections and Treatments
- Vaccine Coverage and Hesitancy
- Pediatric health and respiratory diseases
- Bacterial Infections and Vaccines
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Bacteriophages and microbial interactions
- Respiratory Support and Mechanisms
Jena University Hospital
2016-2025
Friedrich Schiller University Jena
2012-2025
Leibniz Institute of Photonic Technology
2022-2025
German Center for Lung Research
2022-2024
InfectoGnostics Research Campus Jena
2016-2024
National Center for Infectious Diseases
2004-2024
Institut für Krankenhaushygiene & Infektionsprävention
2014-2022
Paul Ehrlich Institut
2021-2022
RELX Group (United States)
2020-2022
La Jolla Alcohol Research
2022
OBJECTIVE To quantify the Hawthorne effect of hand hygiene performance among healthcare workers using direct observation. DESIGN Prospective observational study. SETTING Intensive care unit, university hospital. METHODS Direct observation compliance over 48 audits 2 hours each. Simultaneously, events (HHEs) were recorded electronic alcohol-based handrub dispensers. Directly observed and electronically HHEs during compared Spearman correlations Bland-Altman plots. effect, we number periods...
We performed a multicentre retrospective cohort study including 606,649 acute inpatient episodes at 10 European hospitals in 2010 and 2011 to estimate the impact of antimicrobial resistance on hospital mortality, excess length stay (LOS) cost. Bloodstream infections (BSI) caused by third-generation cephalosporin-resistant Enterobacteriaceae (3GCRE), meticillin-susceptible (MSSA) -resistant Staphylococcus aureus (MRSA) increased daily risk death (adjusted hazard ratio (HR) = 1.80; 95%...
The present guideline provides a new and updated concept of treatment prevention adult patients with community-acquired pneumonia. It replaces the previous dating from 2009.The was worked out agreed on following standards methodology S3-guideline. This includes systematic literature search grading, structured discussion recommendations supported by as well declaration assessment potential conflicts interests.The has focus specific clinical circumstances, an update severity assessment, for...
The correct management of immunocompromised patients with pneumonia is debated. We evaluated the prevalence, risk factors, and characteristics coming from community pneumonia.We conducted a secondary analysis an international, multicenter study enrolling adult hospitalized in 222 hospitals 54 countries worldwide. Risk factors for immunocompromise included AIDS, aplastic anemia, asplenia, hematological cancer, chemotherapy, neutropenia, biological drug use, lung transplantation, chronic...
Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves outcomes. Randomized, multicenter, controlled trial from January 2017 to December 2019. Adult patients (n = 254) sepsis or septic shock were randomly assigned 1:1 receive continuous infusion of piperacillin/tazobactam dosing guided by daily TDM piperacillin a fixed dose (13.5 g/24 h if eGFR ≥ 20 mL/min). Target plasma...
Background: Cardiac surgery often represents the only treatment option in patients with infective endocarditis (IE). However, IE may lead to a sudden release of inflammatory mediators, which is associated postoperative organ dysfunction. We investigated effect hemoadsorption during on Methods: This multicenter, randomized, nonblinded, controlled trial assigned undergoing cardiac for (integration CytoSorb cardiopulmonary bypass) or control. The primary outcome (change sequential failure...
The German Society of Pneumology initiated 2021 the AWMF S1 guideline Long COVID/Post-COVID. In a broad interdisciplinary approach, this was designed based on current state knowledge.The clinical recommendations describe COVID/Post-COVID symptoms, diagnostic approaches, and therapies.In addition to general consensus introduction, subject-specific approach taken summarize has an explicit practical claim will be developed adapted by author team increase in knowledge.Die Deutsche Gesellschaft...
Novel treatments, such as prostanoids or endothelin receptor antagonists, have been introduced for various forms of pulmonary arterial hypertension, but the long-term effects these treatments on portopulmonary hypertension (PPHT) are unknown. In a retrospective analysis, present authors assessed safety and efficacy inhaled iloprost, prostacyclin analogue, bosentan, an antagonist, in patients with PPHT. total, 31 consecutive Child class A B cirrhosis severe PPHT were treated up to 3 yrs...
Blood gas abnormalities in patients with idiopathic pulmonary arterial hypertension (IPAH) may be related to disease severity and prognosis. The present authors performed a 12-yr retrospective analysis assessing arterialised capillary blood gases, haemodynamics, exercise variables survival 101 IPAH. At baseline, oxygen tension (P(a,O(2))) carbon dioxide (P(a,CO(2))) were 9.17+/-1.86 4.25+/-0.532 kPa, respectively. While P(a,O(2) )was not associated survival, low P(a,CO(2 ))was strong...
Background Representative population-based data on the epidemiology of bronchiectasis in Europe are limited. The aim present study was to investigate current burden and trends bronchiectasis-associated hospitalizations associated conditions Germany order inform focused patient care facilitate allocation healthcare resources. Methods nationwide diagnosis-related groups hospital statistics for years 2005–2011 were used identify with as any discharge diagnosis according International...
<b>Objective</b> To examine whether acute dysglycaemia predicts death in people admitted to hospital with community acquired pneumonia. <b>Design</b> Multicentre prospective cohort study. <b>Setting</b> Hospitals and private practices Germany, Switzerland, Austria. <b>Participants</b> 6891 patients pneumonia included the German competence network (CAPNETZ) study between 2003 2009. <b>Main outcome measures</b> Univariable multivariable hazard ratios adjusted for sex, age, current smoking...
Summary Introduction: This article is part of the Focus Theme Methods Information in Medicine on German Medical Informatics Initiative. “Smart Technology for Healthcare (SMITH)” one four consortia funded by Initiative (MI-I) to create an alliance universities, university hospitals, research institutions and IT companies. SMITH’s goals are establish Data Integration Centers (DICs) at each SMITH partner hospital implement use cases which demonstrate usefulness approach. Objectives: To give...
<h3>Objective</h3> To determine differences in aetiologies, initial antimicrobial treatment choices and outcomes patients with nursing-home-acquired pneumonia (NHAP) compared community-acquired (CAP), which is a controversial issue. <h3>Methods</h3> Data from the prospective multicentre Competence Network for Community-acquired (CAPNETZ) database were analysed hospitalised aged ≥65 years CAP or NHAP. Potential baseline characteristics, comorbidities, physical examination findings, severity...
Sepsis contributes considerably to global morbidity and mortality, while reasons for its increasing incidence remain unclear. We assessed risk adjusted secular trends in sepsis infection epidemiology Germany.Retrospective cohort study using nationwide German hospital discharge data. incidence, outcomes of hospital-treated infections between 2010 2015. was identified by explicit ICD-10 codes. As sensitivity analysis, results were compared with cases implicit coding (combined organ dysfunction...
Staphylococcus aureus osteomyelitis often develops to chronicity despite antimicrobial treatments that have been found be susceptible in vitro tests. The complex infection strategies of S. aureus, including host cell invasion and intracellular persistence via the formation dynamic small colony variant (SCV) phenotypes, could responsible for therapy-refractory courses. To analyse efficacy antibiotics acute chronic stage bone infections, we established long-term vivo models. Antibiotics were...
Abstract Purpose Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome emerging from deregulated immune response due to various triggers. In adults, systematic data are sparse, which why recommendations on diagnosis and management have been adopted pediatric guidelines. A nationwide clinical registry with associated consulting service as collaborative initiative of HLH-specialized pediatricians hematologists was initiated better characterize HLH in adults. Methods...
Mycoplasma pneumoniae and Chlamydia spp., which are associated with community-acquired pneumonia (CAP), difficult to propagate, can cause clinically indistinguishable disease patterns. During 2011-2012, we used molecular methods test adult patients in Germany confirmed CAP for infection these 2 pathogens. Overall, 12.3% (96/783) of samples were positive M. 3.9% (31/794) spp.; C. psittaci (2.1%) was detected more frequently than (1.4%). P1 type 1 predominated, levels macrolide resistance low...