Hanaa Shafiek
A5014294722- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Inhalation and Respiratory Drug Delivery
- Pneumonia and Respiratory Infections
- Respiratory and Cough-Related Research
- Obstructive Sleep Apnea Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Cystic Fibrosis Research Advances
- Cancer-related molecular mechanisms research
- Atomic and Subatomic Physics Research
- Respiratory viral infections research
- Advanced Chemical Sensor Technologies
- Head and Neck Cancer Studies
- Heart Rate Variability and Autonomic Control
- Adenosine and Purinergic Signaling
- Emergency and Acute Care Studies
- Nosocomial Infections in ICU
Alexandria University
2014-2024
University of Belgrade
2023
Hopital Universitaire Hedi Chaker
2023
Hospital Universitario Son Espases
2014-2021
Health Research Institute of the Balearic Islands
2021
Université de Yaoundé I
2018
Clinica de Pneumologie Iaşi
2016
Chest Diseases Hospital
2016
The correct management of immunocompromised patients with pneumonia is debated. We evaluated the prevalence, risk factors, and characteristics coming from community pneumonia.We conducted a secondary analysis an international, multicenter study enrolling adult hospitalized in 222 hospitals 54 countries worldwide. Risk factors for immunocompromise included AIDS, aplastic anemia, asplenia, hematological cancer, chemotherapy, neutropenia, biological drug use, lung transplantation, chronic...
Background The electronic nose (e-nose) detects volatile organic compounds (VOCs) in exhaled air. We hypothesized that the VOCs print is different stable vs. exacerbated patients with chronic obstructive pulmonary disease (COPD), particularly if latter associated airway bacterial infection, and e-nose can distinguish them. Methods Smell-prints of bacteria most commonly involved exacerbations COPD (ECOPD) were identified vitro. Subsequently, we tested our hypothesis 93 ECOPD, 19 them...
Patients with poor lung function usually undergo cardiopulmonary exercise testing (CPET) and those a predicted postoperative maximal oxygen consumption (VO2 max) of >10 ml/kg/min resection surgery still some complications are observed. We aimed to determine other parameters beyond VO2 able predict in patients undergoing surgery. This is an observational study longitudinal follow-up. forced expiratory volume 1 second (FEV1) or diffusing capacity for carbon monoxide <40% underwent CPET max...
Severe uncontrolled asthma (SUA) is frequently treated with biologic therapy if a T2 phenotype found. Bronchoscopy not routinely recommended in these patients unless specific indication to rule out comorbidities present.Is routine bronchoscopy safe and useful phenotyping endotyping SUA before the of therapy?Prospective study consecutive who were referred specialized clinic assess therapy. Patients clinically phenotyped as T2-allergic, T2-eosinophilic, non-T2. All underwent bronchoscopy,...
Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder partially resistant to glucocorticoids. A reduced histone deacetylase (HDAC) activity has been proposed explain this resistance. Haemophilus influenzae frequently colonizes the airways of COPD patients, where it enhances inflammation. The effects on HDAC have not investigated before.The presence or absence ex-vivo and in vitro were studied. To end, we determined: (1) cytokine release alveolar macrophages (AM) from 7...
<b><i>Background:</i></b> Probe-based confocal laser endomicroscopy (pCLE) is a novel technique that provides in vivo microscopic imaging of the distal lung. We hypothesized intra-alveolar exudates characterizing <i>Pneumocystis jirovecii </i>pneumonia (PJP) can be identified by pCLE and help its diagnosis. <b><i>Objectives:</i></b> aimed to<b> </b>assess usefulness for diagnosis PJP....
Patients with chronic obstructive pulmonary disease (COPD) frequent exacerbations (ExCOPD) are commonly treated inhaled corticosteroids (ICS) and at risk of infections caused by potential pathogenic bacteria (PPB) including
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory commonly induced by cigarette smoke. The expression of miRNAs can be altered in patients with COPD and could used as biomarker. We aimed to identify panel bronchoalveolar lavage (BAL) differentiate from smokers non-smokers normal lung function. Accordingly, forty-five subjects classified COPD, smokers, (
We aimed to compare the effects of different aerobic exercise training (ET) programs on respiratory performance, capacity, and quality life in fibrosing interstitial lung diseases (f-ILD).A case-control study where 31 patients with f-ILD diagnosis based chest high-resolution computed tomography were recruited from Main Alexandria University hospital-Egypt. Ten randomly assigned for only lower limbs (LL) endurance program, 10 upper limbs, breathing exercises (ULB) program consecutive 18...
Blood eosinophil count (BEC) is currently used as a surrogate marker of T2 inflammation in severe asthma but its relationship with tissue T2-related changes elusive. Bronchial biopsy could add reliable information lacks standardization.To validate systematic assessment the bronchial for evaluation uncontrolled (SUA) by standardizing pathological score.A submucosal inflammation, eosinophilic count/field (TEC), goblet cells hyperplasia, epithelial changes, basement membrane thickening,...
Cystic fibrosis (CF) occurrence in Arab populations is not common and still remains underidentified. Furthermore, the lack of disease awareness diagnosis facilities have mislead identification cystic for decades. The knowledge about Egypt very limited, a few reports drawn attention to existence CF or CFTR-related disorders (CFTR-RDs) Egyptian population. Therefore comprehensive genetic analysis CFTR gene was realized patients North Egypt. DNA samples 56 were screened mutations. 27 exons...
Purpose: Exacerbations of COPD (ECOPD) are a frequent cause hospitalization that seemed to ameliorate during the COVID outbreak. We aimed evaluate clinical characteristics COPD-related hospital admissions and mortality in relation presence COVID-19. Patients Methods: conducted case–control study patients admitted four teaching hospitals throughout Spain between March 15 April 30, 2020. Hospital respiratory with without PCR-proven SARS-CoV-2 infection were evaluated. Baseline episode-related...
Inhaled corticosteroids (ICS) use is associated with an increased risk of Pseudomonas aeruginosa (PA) infection in patients COPD. We aimed to evaluate the effects ICS on alveolar macrophages response PA COPD and without baseline treatment (COPD + ICS, respectively) as well smoker nonsmoker controls. To do so, cells were infected cotreated budesonide (BUD) or fluticasone propionate (FLU). The analysis NF-κB c-jun activity revealed a significant increase both factors BUD/FLU smokers but not...