A5043024042- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Nosocomial Infections in ICU
- COVID-19 Clinical Research Studies
- Cardiac Arrest and Resuscitation
- Long-Term Effects of COVID-19
- Airway Management and Intubation Techniques
- Sepsis Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Clinical Nutrition and Gastroenterology
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Transplantation: Methods and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Family and Patient Care in Intensive Care Units
- Antibiotic Use and Resistance
- Cardiac, Anesthesia and Surgical Outcomes
- Tracheal and airway disorders
- Antifungal resistance and susceptibility
- Frailty in Older Adults
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and exercise physiology
- Organ and Tissue Transplantation Research
- Ultrasound in Clinical Applications
- Electrical and Bioimpedance Tomography
Universitat Pompeu Fabra
2016-2025
META Group
2025
Analysis Group (United States)
2025
Hospital Del Mar
2015-2024
Parc de Salut
2015-2023
Hospital del Mar Research Institute
2015-2023
Universitat Autònoma de Barcelona
2010-2022
Municipal Institute for Medical Research
2016-2021
Weatherford College
1998-2021
Instituto de Salud Carlos III
2012-2020
Rationale: One important concern during high-flow nasal cannula (HFNC) therapy in patients with acute hypoxemic respiratory failure is to not delay intubation. Objectives: To validate the diagnostic accuracy of an index (termed ROX and defined as ratio oxygen saturation measured by pulse oximetry/FiO2 rate) for determining HFNC outcome (need or intubation). Methods: This was a 2-year multicenter prospective observational cohort study including pneumonia treated HFNC. Identification through...
Traditionally, high-flow oxygen therapy (HFOT) was defined as the delivery of a flow higher than 6 L/min. Recently, however, method has been described in which flows up to 50 L/min are delivered through nasal cannula with heated humidifier that optimizes administration. HFOT improves oxygenation by various mechanisms, for instance decreasing dilution, reducing respiratory dead space, and generating continuous positive airway pressure effect. It may also have beneficial effect on...
Electrical impedance tomography measures changes in lung impedance, which are mainly related to volume. We used electrical investigate the effects of high-flow nasal cannula (HFNC) and body position on global regional end-expiratory variation (ΔEELI).Prospective study with 20 healthy adults. Two periods were defined: first supine second prone position. Each period was divided into 3 phases. In third phases subjects breathing ambient air, HFNC implemented. Four regions interest 2 ventral...
Background: The first wave of COVID-19 pandemic may have significantly impacted antimicrobial consumption in hospitals. objective this study was to assess the evolution during period. Methods: A retrospective quasi-experimental before–after conducted a Spanish tertiary care hospital. compared two periods: pre-pandemic, from January 2018 February 2020, and March June 2020. Antimicrobial analyzed monthly as defined daily doses (DDD)/100 bed-days overall hospital ICU were evaluated. Results: An...
The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association disease severity crucial to understand pathophysiology, guide decisions. This study aimed at assessing critical in hospitalized patients. Forty-nine patients were enrolled a prospective, observational, single-center Barcelona, Spain. Demographic, clinical, analytical data admission registered. Plasma samples collected within...
Lower respiratory tract infections (LRTI) are the most frequent infectious complication in patients admitted to intensive care unit (ICU). We aim report clinical characteristics of ICU-admitted due nosocomial LRTI and describe their microbiology outcomes.A prospective observational study was conducted 13 countries over two continents from 9th May 2016 until 16th August 2019. Characteristics outcomes ventilator-associated pneumonia (VAP), tracheobronchitis (VAT), ICU hospital-acquired...
The effectiveness of humidified high flow nasal cannula (HFNC) in lung transplant (LTx) recipients readmitted to intensive care unit (ICU) because acute respiratory failure (ARF) has not been determined date.Retrospective analysis a prospectively assessed cohort LTx patients who were ICU ARF over 5-year period. Patients received conventional oxygen therapy (COT) or HFNC (Optiflow, Fisher & Paykel, New Zealand) supportive according the attending physician's criteria. Treatment was defined as...
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Extubation failure is associated with increased morbidity and mortality, but cannot be safely predicted or avoided. High-flow nasal cannula (HFNC) prevents postextubation respiratory in low-risk patients.To demonstrate that HFNC reduces high-risk non-hypercapnic patients compared conventional oxygen.Randomized, controlled multicenter trial who passed a spontaneous breathing trial. We enrolled meeting criteria for of to randomly receive oxygen 24 h after extubation. Primary outcome was within...
<h3>BACKGROUND:</h3> Despite wide use of noninvasive ventilation (NIV) in several clinical settings, the beneficial effects NIV patients with hypoxemic acute respiratory failure (ARF) due to influenza infection remain controversial. The aim this study was identify profile risk factors for using chi-square automatic interaction detection (CHAID) analysis and determine whether is associated ICU mortality. <h3>METHODS:</h3> This work a secondary from prospective observational multi-center...
Abstract Background The optimal time to intubate patients with SARS-CoV-2 pneumonia has not been adequately determined. While the use of non-invasive respiratory support before invasive mechanical ventilation might cause patient-self-induced lung injury and worsen prognosis, (NIV) is frequently used avoid intubation acute failure (ARF). We hypothesized that delayed associated a high risk mortality in COVID-19 patients. Methods This secondary analysis prospectively collected data from adult...
Erythropoietin (rHuEPO) has proven to be effective in the treatment of anemia chronic renal failure (CRF). Despite improving quality life, peak oxygen uptake after rHuEPO therapy is not improved as much increase hemoglobin concentration ([Hb)] would predict. We hypothesized that this discrepancy due O2 transport rates rise a manner proportional [Hb]. To test this, eight patients with CRF undergoing regular hemodialysis were studied pre- and post-rHuEPO ([Hb] = 7.5 +/- 1.0 vs. 12.5 g x dl-1)...
Background: Nosocomial lower respiratory tract infections (nLRTIs) are associated with unfavorable clinical outcomes and significant healthcare costs. nLRTIs include hospital-acquired pneumonia (HAP), ventilator-associated (VAP), other ICU-acquired phenotypes. While risk factors for mortality in these critical to guide preventive strategies, it remains unclear whether they vary based on their requirement of invasive mechanical ventilation (IMV) at any point during the hospitalization....