A5031220694- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Long-Term Effects of COVID-19
- Cystic Fibrosis Research Advances
- Antibiotic Use and Resistance
- Emergency and Acute Care Studies
- Chronic Disease Management Strategies
- Respiratory and Cough-Related Research
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Inhalation and Respiratory Drug Delivery
- Clostridium difficile and Clostridium perfringens research
- Tracheal and airway disorders
- COVID-19 and healthcare impacts
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Vaccine Coverage and Hesitancy
- PARP inhibition in cancer therapy
- COVID-19 diagnosis using AI
Universidad de La Sabana
2020-2025
Lower respiratory tract infections (LRTI) are the most frequent infectious complication in patients admitted to intensive care unit (ICU). We aim report clinical characteristics of ICU-admitted due nosocomial LRTI and describe their microbiology outcomes.A prospective observational study was conducted 13 countries over two continents from 9th May 2016 until 16th August 2019. Characteristics outcomes ventilator-associated pneumonia (VAP), tracheobronchitis (VAT), ICU hospital-acquired...
Purpose The COVID-19 pandemic has spread worldwide, and almost 396 million people have been infected around the globe. Latin American countries deeply affected, there is a lack of data in this regard. This study aims to identify clinical characteristics, in-hospital outcomes, factors associated with ICU admission due COVID-19. Furthermore, describe functional status patients at hospital discharge after acute episode Material methods was prospective, multicenter, multinational observational...
Abstract Around one-third of patients diagnosed with COVID-19 develop a severe illness that requires admission to the Intensive Care Unit (ICU). In clinical practice, clinicians have learned admitted ICU due frequently ventilator-associated lower respiratory tract infections (VA-LRTI). This study aims describe characteristics, factors associated VA-LRTI, and its impact on outcomes in COVID-19. was multicentre, observational cohort conducted ten countries Latin America Europe. We included...
Up to 30% of patients admitted hospitals with invasive pneumococcal disease (IPD) experience major adverse cardiovascular event (MACE) including new/worsening heart failure, arrhythmia, and/or myocardial infarction. Streptococcus pneumoniae (Spn) is the most frequently isolated bacterial pathogen among community-acquired pneumonia (CAP) and only etiological agent linked independently MACE. Nevertheless, no clinical data exist identifying which serotypes Spn are principally responsible for...
Patients with community-acquired pneumonia (CAP) admitted to the intensive care unit (ICU) have high mortality rates during acute infection and up ten years thereafter. Recommendations from international CAP guidelines include macrolide-based treatment. However, there is no data on long-term outcomes of this recommendation. Therefore, we aimed determine impact therapy in population.Registered patients MIMIC-IV database 16 or older ICU due were included. Multivariate analysis, targeted...
Background: Nosocomial lower respiratory tract infections (nLRTIs) are associated with unfavorable clinical outcomes and significant healthcare costs. nLRTIs include hospital-acquired pneumonia (HAP), ventilator-associated (VAP), other ICU-acquired phenotypes. While risk factors for mortality in these critical to guide preventive strategies, it remains unclear whether they vary based on their requirement of invasive mechanical ventilation (IMV) at any point during the hospitalization....
Abstract Background Nosocomial low respiratory infections (nLRTIs) represent a significant complication prevalent among patients who require admission to the intensive care unit (ICU). Gram-negative microorganisms are related nLRTIs, such as ventilator-associated pneumonia (VAP), tracheobronchitis (VAT), ICU-acquired (ICU-HAP), and hospital-acquired (HAP). Pseudomonas aeruginosa (PA) is frequently identified nLRTIs; however, not all with nLRTI may antipseudomonal treatment this clear in...
Abstract Background Microorganisms causing healthcare-associated infections are usually difficult to treat Gram-negative bacteria, making the empiric antibiotic selection challenging. Pseudomonas aeruginosa (PA) is a microorganism associated with hospital-acquired infections, and its rate of antimicrobial resistance has increased in last ten years. However, international prevalence P. ICU-Related Respiratory Infections (ICU-RRI) unknown. This study aims bridge this gap literature using...
Purpose Streptococcus pneumoniae (Spn ) is the primary bacterial cause of lower respiratory tract infections (LRTI) globally, particularly impacting older adults and children. While Spn colonization in children linked to LRTI, its prevalence, consequences with comorbidities remain uncertain. This study aims provide novel data that regard. Methods prospective outpatient chronic diseases was conducted Colombia. Data on demographics, vaccination, clinical history collected a RedCap database....
<title>Abstract</title> Rationale: Ventilator-associated pneumonia (VAP) is a common complication in patients under invasive mechanical ventilation (IMV), yet its underlying mechanisms remain poorly understood. This study investigated the lung microbiome, inflammatory response, and metabolism undergoing IMV to identify factors that may predispose them developing VAP. Objectives: To investigate how changes microbiome composition, metabolic profiles develop Methods: Patients requiring for at...
The mechanisms used by SARS-CoV-2 to induce major adverse cardiac events (MACE) are unknown. Thus, we aimed determine if can necrotic cell death promote MACE in patients with severe COVID-19.
Abstract Background Inflammatory responses contribute to tissue damage in COVID-19 and community-acquired pneumonia (CAP). Although predictive values of different inflammatory biomarkers have been reported both, similarities differences profiles between these conditions remain uncertain. Therefore, we aimed determine the CAP, their association with clinical outcomes. Methods We report a prospective observational cohort study; conducted reference hospital Latin America. Patients confirmed CAP...
The incidence of invasive pneumococcal disease (IPD) varies depending on a number factors, including vaccine uptake, in both children and adults, the geographic location, local serotype prevalence. There are limited data about burden Streptococcus pneumoniae (Spn), distribution, clinical characteristics adults hospitalized due to IPD Colombia. objectives this study included assessment Spn characteristics, mortality, ICU admission, need for mechanical ventilation.This was an observational,...
Background Patients with coronavirus disease 2019 (COVID-19) could develop severe requiring admission to the intensive care unit (ICU). This article presents a novel method that predicts whether patient will need ICU and assesses risk of in-hospital mortality by training deep-learning model combines set clinical variables features in chest radiographs. Methods was prospective diagnostic test study. confirmed acute respiratory syndrome 2 infection between March 2020 January 2021 were...
Compare the changes and differences in metabolome lipidome profiles among severe COVID-19 CAP patients with ARF to identify biomarkers that could be used for personalized diagnosis, prognosis, treatment.
Abstract Background Pneumonia remains a significant global health concern, particularly among those requiring admission to the intensive care unit (ICU). Despite availability of international guidelines, there heterogeneity in clinical management. The D-PRISM study aimed develop overview how pneumonias (i.e., community-acquired (CAP), hospital-acquired (HAP), and Ventilator-associated pneumonia (VAP)) are diagnosed treated ICU compare differences practice worldwide. Methods was...
ABSTRACT In this study, the genetic differences and clinical impact of carbapenemase-encoding genes among community healthcare-acquired infections were assessed. This retrospective, multicenter cohort study was conducted in Colombia included patients infected with carbapenem-resistant Gram-negative rods between 2017 2021. Carbapenem resistance identified by Vitek, whole-genome sequencing (WGS) to classify alleles sequence types (STs). Descriptive statistics used determine association any...
<title>Abstract</title> <bold>Purpose</bold>: <italic>Streptococcus pneumoniae (Spn</italic>) is the primary bacterial cause of lower respiratory tract infections (LRTI) globally, particularly impacting older adults and children. While <italic>Spn</italic> colonization in children linked to LRTI, its prevalence consequences with comorbidities remains uncertain. This study aims provide novel data that regard. <bold>Methods</bold>: a prospective outpatient chronic diseases. Data on...
Abstract Cefepime and piperacillin/tazobactam are antimicrobials recommended by IDSA/ATS guidelines for the empirical management of patients admitted to intensive care unit (ICU) with community-acquired pneumonia (CAP). Concerns have been raised about which should be used in clinical practice. This study aims compare effect cefepime critically ill CAP through a targeted maximum likelihood estimation (TMLE). A total 2026 ICU-admitted were included. Among them, (47%) presented respiratory...
Background The mechanisms used by SARS-CoV-2 to induce major adverse cardiac events (MACE) are unknown. Thus, we aimed determine if can infect the heart kill cardiomyocytes and MACE in patients with severe COVID-19. Methods This observational prospective cohort study includes experiments hamsters human samples from Cytokines serum biomarkers were analyzed serum. Cardiac transcriptome analyses performed hamsters' hearts. Results From a of 70 patients, was documented 26% (18/70). Those who...