A5042990512- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Respiratory viral infections research
- Antibiotics Pharmacokinetics and Efficacy
- Pneumocystis jirovecii pneumonia detection and treatment
- Influenza Virus Research Studies
- Emergency and Acute Care Studies
- Antifungal resistance and susceptibility
- Intensive Care Unit Cognitive Disorders
- Bacterial Identification and Susceptibility Testing
- Central Venous Catheters and Hemodialysis
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- Inhalation and Respiratory Drug Delivery
- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Hemodynamic Monitoring and Therapy
- Airway Management and Intubation Techniques
- Cardiac Arrest and Resuscitation
- Long-Term Effects of COVID-19
- Fungal Infections and Studies
Université de Nîmes
2020-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2016-2025
Vall d'Hebron Institut de Recerca
2016-2025
Université de Montpellier
2020-2025
Centro de Investigación Biomédica en Red
2015-2025
Instituto de Salud Carlos III
2016-2025
Centre Hospitalier Universitaire de Nîmes
2020-2025
Vall d'Hebron Hospital Universitari
2014-2024
Universitat Internacional de Catalunya
2020-2024
Network Group (Czechia)
2023
Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in achieves concentrations associated maximal activity affect patient outcome.This was prospective, multinational pharmacokinetic point-prevalence study including 8 antibiotics. Two blood samples were taken from each during single interval. The primary pharmacokinetic/pharmacodynamic targets free above the minimum inhibitory...
In order to assess potential risk factors for pneumonia within the first 8 d of ventilation, we studied 83 consecutive intubated patients undergoing continuous aspiration subglottic secretions (CASS). Multivariate analysis showed protective effect antibiotic use (relative [RR] = 0.10; 95% confidence interval [CI] 0.01 0.71), whereas failure CASS technique (RR 5.29; CI 1.24 22.64) was associated with a greater pneumonia. addition, there trend toward higher 2.57; 0.78 8.03) among persistent...
Rationale: The clinical relevance of Aspergillus-positive endotracheal aspirates in critically ill patients is difficult to assess.Objectives: We externally validate a algorithm discriminate Aspergillus colonization from putative invasive pulmonary aspergillosis this patient group.Methods: performed multicenter (n = 30) observational study including with one or more aspirate cultures 524). diagnostic accuracy was evaluated using 115 histopathologic data, considered the gold standard....
The use of microbiologic investigations in routine clinical practice, their value guiding antibiotic prescription, and influence on outcome were prospectively studied 113 consecutive adults who developed ventilator-associated pneumonia (VAP). Blood cultures performed 78.7% cases, protected specimen brushing 95.5%, bronchoalveolar lavage only 45.1%. No causative agent was identified 13 episodes (11.5%), results microbial tests directed a change therapy 43 (38.0%). Bronchoscopic revealed...
Abstract Introduction Patients with influenza A (H1N1)v infection have developed rapidly progressive lower respiratory tract disease resulting in failure. We describe the clinical and epidemiologic characteristics of first 32 persons reported to be admitted intensive care unit (ICU) due Spain. Methods used medical chart reviews collect data on ICU adult patients a standardized form. Influenza was confirmed specimens using real-time reverse transcriptase-polymerase-chain-reaction (RT PCR)...
We performed a prospective, international, observational study of 844 hospitalized patients with blood cultures positive for Streptococcus pneumoniae. Fifteen percent isolates had in vitro intermediate susceptibility to penicillin (minimum inhibitory concentration [MIC], 0.12–1 μg/mL), and 9.6% were resistant (MIC, ⩾2 μg/mL). Age, severity illness, underlying disease immunosuppression significantly associated mortality; resistance was not risk factor mortality. The impact concordant...
Retrospective studies have suggested that combination antibiotic therapy for severe bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a prospective, multicenter, international observational study of 844 adult patients with bacteremia due to Streptococcus pneumoniae. The effect versus monotherapy on mortality was examined by univariate analyses and logistic regression models. 14-day not significantly different the two groups. However, among critically ill...
All episodes of ventilator-associated pneumonia (VAP) caused by Staphylococcus aureus were prospectively analyzed for a 30-mo period. Methicillin-sensitive S. (MSSA) was isolated in 38 and methicillin-resistant (MRSA) 11 others. The two groups similar regarding sex, severity underlying diseases, prior surgery, presence renal failure, diabetes, cardiopathy, coma. MRSA-infected persons more likely to have received steroids before developing infection (relative risk [RR] = 3.45, 95% confidence...
Objective Pseudomonas aeruginosa is a frequent cause of ventilator-associated pneumonia. Recent evidence suggests that production type III secretion proteins correlated with increased pathogenicity in both cellular and animal models infection. The objective this study was to determine whether system contributes disease severity humans Design Retrospective pilot cohort study. Setting University hospital. Patients Thirty-five mechanically ventilated patients bronchoscopically confirmed...
Abstract Introduction Invasive aspergillosis (IA) is a fungal infection that particularly affects immunocompromised hosts. Recently, several studies have indicated high incidence of IA in intensive care unit (ICU) patients. However, few data are available on the epidemiology and outcome patients with this setting. Methods An observational study including all positive Aspergillus culture during ICU stay was performed 30 ICUs 8 countries. Cases were classified as proven IA, putative or...
Human host immune response following infection with the new variant of A/H1N1 pandemic influenza virus (nvH1N1) is poorly understood. We utilize here systemic cytokine and antibody levels in evaluating differences early both mild severe patients infected nvH1N1.We profiled 29 cytokines chemokines evaluated haemagglutination inhibition activity as quantitative qualitative measurements responses serum obtained during first five days after symptoms onset, two cohorts nvH1N1 patients. Severe...
Abstract Background Antibiotics may be indicated in patients with COVID-19 due to suspected or confirmed bacterial superinfection. Objectives To investigate antibiotic prescribing practices COVID-19. Methods We performed an international web-based survey and investigated the pattern of use as reported by physicians involved treatment SPSS Statistics version 25 was used for data analysis. Results The completed 166 participants from 23 countries 82 different hospitals. Local guidelines were...
Pseudomonas aeruginosa nosocomial pneumonia (Pa-NP) is associated with considerable morbidity, prolonged hospitalization, increased costs, and mortality.We conducted a retrospective cohort study of adult patients Pa-NP to determine 1) risk factors for multidrug-resistant (MDR) strains 2) whether MDR increases the hospital death. Twelve hospitals in 5 countries (United States, n = 3; France, 2; Germany, Italy, Spain, 3) participated. We compared characteristics who had those did not derived...