A5045133259- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Gut microbiota and health
- Tracheal and airway disorders
- Cystic Fibrosis Research Advances
- Emergency and Acute Care Studies
- Pediatric health and respiratory diseases
- Antifungal resistance and susceptibility
- Asthma and respiratory diseases
- Pleural and Pulmonary Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antibiotic Use and Resistance
- Occupational and environmental lung diseases
- Bone health and osteoporosis research
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Occupational exposure and asthma
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Influenza Virus Research Studies
Corporació Sanitària Parc Taulí
2012-2024
Universitat Autònoma de Barcelona
2009-2024
Institute of Research and Innovation Parc Tauli
2013-2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2014-2024
Instituto de Salud Carlos III
2013-2024
Vall d'Hebron Institut de Recerca
2024
Vall d'Hebron Hospital Universitari
2024
Universidad Complutense de Madrid
2024
Deleted Institution
2012-2022
University Hospital St. Marina
2018
The use of microbiologic investigations in routine clinical practice, their value guiding antibiotic prescription, and influence on outcome were prospectively studied 113 consecutive adults who developed ventilator-associated pneumonia (VAP). Blood cultures performed 78.7% cases, protected specimen brushing 95.5%, bronchoalveolar lavage only 45.1%. No causative agent was identified 13 episodes (11.5%), results microbial tests directed a change therapy 43 (38.0%). Bronchoscopic revealed...
ABSTRACT Bronchial colonization by potentially pathogenic microorganisms (PPMs) is often demonstrated in chronic obstructive pulmonary disease (COPD), but culture-based techniques identify only a portion of the bacteria mucosal surfaces. The aim study was to determine changes bronchial microbiome COPD associated with severity disease. patients analyzed 16S rRNA gene amplification and pyrosequencing sputum samples obtained during stable Seventeen were studied (forced expiratory volume first...
To develop a severity assessment tool to predict mortality in community-acquired pneumonia (CAP) patients intensive care unit (ICU), comparing its performance with Acute Physiology and Chronic Health Evaluation (APACHE) II score American Thoracic Society/Infectious Disease Society of America (ATS/IDSA) criteria as prognostic index CAP requiring ICU admission.Secondary analysis prospective observational cohort study.Thirty-three ICUs.Five hundred twenty-nine adult admission.A was developed...
The bronchial microbiome in severe COPD during stability and exacerbation patients chronically colonised by Pseudomonas aeruginosa (PA), has not been defined. Our objective was to determine the characteristics of P. its changes exacerbation. with disease frequent exacerbations were categorised according chronic colonisation aeruginosa. Sputum samples obtained exacerbation, cultured, analysed 16S rRNA gene amplification pyrosequencing. Sixteen included, 5 them showing genus had significantly...
Patients with severe chronic obstructive pulmonary disease (COPD) are at increased risk of infection by P. aeruginosa. The specific role bronchiectasis in both and colonization this microorganism COPD, however, remains ill defined. To evaluate the prevalence factors for aeruginosa recovery from sputum outpatients characterizing isolates pulsed-field gel electrophoresis (PFGE) focusing on influence these patients. A case-cohort study 118 patients COPD attended a Respiratory Day Unit an acute...
Pneumocystis jirovecii pneumonia (PJP) is an opportunistic, life-threatening disease commonly affecting immunocompromised patients. The distribution of predisposing diseases or conditions in critically ill patients admitted to intensive care unit (ICU) and subjected diagnostic work-up for PJP has seldom been explored.The primary objective the study was describe characteristics ICU workup PJP. secondary objectives were: (i) assess demographic clinical variables associated with PJP; (ii)...
To evaluate the effect of discordant empirical therapy on outcome in bacteremic pneumococcal community-acquired pneumonia.Prospective observational study.A 600-bed teaching hospital with a reference area 400,000 inhabitants.All patients aged > or =18 yrs diagnosis pneumonia whose blood cultures, obtained within first 48 hrs hospitalization, demonstrated growth Streptococcus pneumoniae were included study.Discordant was defined as failure to administer an antibiotic vitro activity against...
The influence of infecting serotype group on outcome in bacteraemic pneumococcal pneumonia remains unclear. We performed a prospective, 10-yr observational study an 800-bed teaching hospital. 299 adults diagnosed with whose blood cultures showed growth Streptococcus pneumoniae were included the study. High invasive disease potential (H) serotypes 1, 5 and 7F, which served as reference category, compared low (L) (3, 6A, 6B, 8, 19F, 23F) other (O) (non-H, non-L). was determined for each after...
Background. The 13-valent pneumococcal conjugate vaccine (PCV13) has recently been approved for use in immunocompromised adults. However, it is unclear whether there an association between specific underlying conditions and infection by individual serotypes. objective was to determine the prevalence of serotypes covered PCV13 a cohort patients with invasive disease respiratory origin are risk factors each serotype. Methods. An observational study adults hospitalized 2 Spanish hospitals...
The course of chronic obstructive pulmonary disease (COPD) is frequently aggravated by exacerbations, and changes in the composition activity microbiome may be implicated their appearance. aim this study was to analyse gene content microbial community bronchial secretions COPD patients both stability exacerbation. Taxonomic data were obtained 16S rRNA amplification pyrosequencing, metabolic information through shotgun metagenomics, using Metagenomics RAST server (MG-RAST), PICRUSt...
C-reactive protein (CRP) measurement has proven valuable for detecting exacerbations, but its usefulness in predicting etiology remains controversial. Likewise, potential value as a marker of severity, which is well established patients with pneumonia, unproven chronic obstructive pulmonary disease (COPD) exacerbations.A cohort study 118 severe COPD and acute infectious exacerbations were included followed up over 1 year. Episodes meeting Anthonisen's criteria type I-II evaluated, analyzing...
Staging of mediastinal lymph nodes in non-small cell lung cancer (NSCLC) is mandatory. The maximum Standard Uptake Value (SUVmax) obtained using F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) the best non-invasive technique available for this evaluation, but its performance varies from center to center. aim present study was identify FDG-PET predictors malignancy that are able minimize intercenter variability and improve selection subsequent staging procedures. A multicenter...