A5108042852- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Sarcoma Diagnosis and Treatment
- Vasculitis and related conditions
- Histiocytic Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Bladder and Urothelial Cancer Treatments
- Respiratory Support and Mechanisms
- Renal Transplantation Outcomes and Treatments
- Mast cells and histamine
- Colorectal and Anal Carcinomas
- Adrenal Hormones and Disorders
- Cell Adhesion Molecules Research
- Mechanical Circulatory Support Devices
- Bone Metabolism and Diseases
- Eosinophilic Disorders and Syndromes
- Polyomavirus and related diseases
- Sarcoidosis and Beryllium Toxicity Research
- Renal Diseases and Glomerulopathies
- Otitis Media and Relapsing Polychondritis
- Soft tissue tumor case studies
- Cardiac Arrest and Resuscitation
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
University of Liège
2024
Nantes Université
1983-2023
Centre Hospitalier Universitaire de Lille
2017-2023
Centre Hospitalier Départemental Vendée
2023
Roche (France)
2023
Centre Hospitalier Universitaire de Nantes
1999-2022
Université de Lille
2017-2020
Hotel Dieu Hospital
1992-2018
Hôtel-Dieu de Paris
1997-2016
Hôpital Ambroise-Paré
2016
Long-term allograft survival generally requires lifelong immunosuppression (IS). Rarely, recipients display spontaneous "operational tolerance" with stable graft function in the absence of IS. The lack biological markers this phenomenon precludes identification potentially tolerant patients which IS could be tapered and hinders development new tolerance-inducing strategies. objective study was to identify minimally invasive blood biomarkers for operational tolerance use these determine...
Background Since 2010, nationwide networks of reference centers for sarcomas (RREPS/NETSARC/RESOS) collected and prospectively reviewed all cases connective tumors intermediate malignancy (TIM) in France. Methods The incidence sarcoma or TIM (2013–2016) was measured using the 2013 WHO classification confirmed by a second independent review expert pathologists. Simple clinical characteristics, yearly variations correlation with published trials are presented analyzed. Results Over 150...
Abstract Interleukin‐34 (IL‐34) is a newly discovered regulator of myeloid lineage differentiation, proliferation, and survival, acting via the macrophage‐colony stimulating factor receptor (M‐CSF receptor, c‐fms). M‐CSF, main ligand for c‐fms, required osteoclastogenesis has been already identified as critical contributor pathogenesis giant cell tumours bone (GCTs), rich in osteoclasts. According to key role M‐CSF GCTs, expression IL‐34 human GCTs was first assessed. Quantitative analysis...
Abstract RANK, RANK ligand (RANKL) and osteoprotegerin (OPG) are the key regulators of bone metabolism, both in normal pathological conditions. Previous data have demonstrated that human osteosarcoma biopsies express RANKL as well OPG, functional is expressed a murine cell line. As expression remains controversial, aim present study was to analyse its vitro lines, ex vivo using tissues, then determine functionality terms signal transduction pathways modulated by RANKL. RT‐PCR analysis...
Data regarding the incidence and outcome of renal involvement in patients with inflammatory myopathies (IM) remain scarce. We assessed causes acute kidney injury (AKI) chronic disease (CKD) 150 dermatomyositis, polymyositis, antisynthetase syndrome followed 3 French referral centers. Renal occurred 35 (23.3%) patients: AKI 16 (10.7%), CKD 31 (20.7%) patients. The main cause was drug or myoglobinuria-induced tubular necrosis. Male sex, cardiovascular risk factors, cardiac involvement, initial...
Giant cell tumors (GCTs) with high mobility group AT-Hook 2 ( HMGA2 )::nuclear receptor corepressor NCOR2 ) fusion are rare mesenchymal of controversial nosology, which have been anecdotally reported to respond CSFR1 inhibitors. Here, we performed a comprehensive study 6 GCTs HMGA2::NCOR2 and explored their relationship other giant cell-rich neoplasms. Tumors occurred in 4 females males ranging age from 17 32 years old (median 24). Three lesions originated subcutaneous soft tissue 3 bone....
Hodgkin's disease (HD) has seldom been reported after transplantation. Epstein-Barr virus (EBV) is present in about 50% of Reed-Sternberg cells HD developing immunocompetent individuals, but more frequently found acquired immune deficiency syndrome patients. We report 7 cases that occurred transplant recipients. Clinical and pathological data studies EBV reveal specific features Six patients received kidney transplants 1 patient combined pancreas Immunosuppressive therapy consisted...
The outcomes of patients admitted to the intensive care unit (ICU) for acute manifestation small-vessel vasculitis are poorly reported. aim present study was determine mortality rate and prognostic factors ICU vasculitis.This retrospective, multicenter conducted from January 2001 December 2014 in 20 ICUs France. Patients were identified computerized registers each hospital using International Classification Diseases, Ninth Revision (ICD-9). Inclusion criteria (1) known or highly suspected...
It is unclear whether influenza infection and associated co-infection are with patient-important outcomes in critically ill immunocompromised patients acute respiratory failure. Preplanned secondary analysis of EFRAIM, a prospective cohort study 68 hospitals 16 countries. We included 1611 aged 18 years or older non-AIDS-related immunocompromise, who were admitted to the ICU hypoxemic The main exposure interest was status. primary outcome all-cause hospital mortality, length stay (LOS) 90-day...
A case of fatal Epstein–Barr virus infection in a previously healthy girl who was first found to have severe infectious mononucleosis with spontaneous recovery is reported. Because an abnormal immune response the persisted, disease relapsed, manifesting cutaneous and pulmonary lesions associated hemophagocytic syndrome responsible for death. Pathologic findings were characterized by polymorphous atypical lymphoid infiltrate, prominent necrosis, histiocytic hyperplasia. Lymphoid cells...
Targeted monoclonal antibody (mAb) therapies show great promise for the treatment of transplant rejection and autoimmune diseases by inducing more specific immunomodulatory effects than broadly immunosuppressive drugs routinely used. We recently described therapeutic advantage targeting CD45RC, expressed at high levels conventional T (Tconv) cells (CD45RChi), their precursors, terminally differentiated (TEMRA) cells, but not regulatory (Tregs; CD45RClo/-). demonstrated efficacy anti-CD45RC...
No gold standard exists for histopathological diagnosis of a prosthetic joint infection (PJI). The historical criterion considers the presence neutrophil infiltration upon examination periprosthetic tissue. Morawietz et al. proposed classification membranes (Morawietz al., Clin Pathol 59:591-597, 2006, https://doi.org/10.1136/jcp.2005.027458) and more recently described with new cutoff value 23 neutrophils in 10 high-power fields Histopathology 54:847-853, 2009....