Ángel Estella
A5072318547- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Palliative Care and End-of-Life Issues
- Intensive Care Unit Cognitive Disorders
- Family and Patient Care in Intensive Care Units
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- Ethics in medical practice
- Influenza Virus Research Studies
- Antibiotic Use and Resistance
- Disaster Response and Management
- Cardiac Arrest and Resuscitation
- SARS-CoV-2 and COVID-19 Research
- Emergency and Acute Care Studies
- Antifungal resistance and susceptibility
- Thermal Regulation in Medicine
- Respiratory viral infections research
- Cardiac, Anesthesia and Surgical Outcomes
- Machine Learning in Healthcare
- COVID-19 and healthcare impacts
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 diagnosis using AI
- Airway Management and Intubation Techniques
Biomedical Research and Innovation Institute of Cadiz
2021-2025
Hospital Jerez Puerta del Sur
2016-2025
Universidad de Cádiz
2020-2025
Hospital Universitario de Getafe
2022-2023
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2022-2023
Instituto de Salud Carlos III
2023
Hospital San Pedro
2022
Hospital San Agustin
2022
Complejo Hospitalario Universitario de Santiago
2021
Universidad de Navarra
2019-2021
<h3>Importance</h3> End-of-life decisions occur daily in intensive care units (ICUs) around the world, and these practices could change over time. <h3>Objective</h3> To determine changes end-of-life European ICUs after 16 years. <h3>Design, Setting, Participants</h3> Ethicus-2 was a prospective observational study of 22 previously included Ethicus-1 (1999-2000). During self-selected continuous 6-month period at each ICU, consecutive patients who died or had any limitation life-sustaining...
The identification of factors associated with Intensive Care Unit (ICU) mortality and derived clinical phenotypes in COVID-19 patients could help for a more tailored approach to decision-making that improves prognostic outcomes.Prospective, multicenter, observational study critically ill confirmed disease acute respiratory failure admitted from 63 ICUs Spain. objective was utilize an unsupervised clustering analysis derive analyze patient's risk. Patient features including demographics data...
Abstract Background Colistin is recommended in the empirical treatment of ventilator-associated pneumonia (VAP) with a high prevalence carbapenem-resistant gram-negative bacilli (CR-GNB). However, efficacy and safety colistin are not well defined. Methods A multicenter prospective randomized trial conducted 32 European centers compared (4.5 million unit loading dose followed by maintenance 3 units every 8 h) versus meropenem (2 g h), both combination levofloxacin (500 mg 12 for 7–14 days...
The primary aim of our study was to investigate the association between intubation timing and hospital mortality in critically ill patients with coronavirus disease 2019 (COVID-19)-associated respiratory failure. We also analysed both impact such throughout first four pandemic waves influence prior noninvasive support on outcomes.This is a secondary analysis multicentre, observational prospective cohort that included all consecutive undergoing invasive mechanical ventilation due COVID-19...
Dexamethasone is the only drug that has consistently reduced mortality in patients with COVID-19, especially needing oxygen or invasive mechanical ventilation. However, there a growing concern about relation of dexamethasone unprecedented rates ICU-acquired respiratory tract infections (ICU-RTI) observed severe COVID-19.This was multicenter, prospective cohort study; conducted ten countries Latin America and Europe. We included older than 18 confirmed SARS-CoV-2 requiring ICU admission. A...
Abstract Around one-third of patients diagnosed with COVID-19 develop a severe illness that requires admission to the Intensive Care Unit (ICU). In clinical practice, clinicians have learned admitted ICU due frequently ventilator-associated lower respiratory tract infections (VA-LRTI). This study aims describe characteristics, factors associated VA-LRTI, and its impact on outcomes in COVID-19. was multicentre, observational cohort conducted ten countries Latin America Europe. We included...
Although the prevalence of community-acquired respiratory bacterial coinfection upon hospital admission in patients with coronavirus disease 2019 (COVID-19) has been reported to be < 5%, almost three-quarters received antibiotics. We aim investigate whether procalcitonin (PCT) or C-reactive protein (CRP) could helpful biomarkers identify among COVID-19 pneumonia. carried out a multicentre, observational cohort study including consecutive admitted 55 Spanish intensive care units (ICUs). The...
Abstract Background Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study investigate associations between mortality and variables measured during first three days ventilation with intubated at ICU admission. Methods Multicenter, observational, cohort includes consecutive admitted 44 Spanish ICUs February 25 July 31, 2020, who required intubation admission for more than days. We collected demographic clinical data prior...
The objective of this study was to evaluate the impact empirical therapy with fluconazole or an echinocandin on 30- and 90-day mortality in critically ill patients candidemia. outcome whom deescalated also assessed.Retrospective, observational multicenter study.Medical surgical ICUs nine Spanish hospitals.Adult (≥ 18 yr) episode Candida bloodstream infection during ICU admission from January 2011 April 2016.Patient characteristics, infection-related variables, therapeutic interventions,...