Luís Coelho
A5060502961- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Platelet Disorders and Treatments
- Bacterial Identification and Susceptibility Testing
- Long-Term Effects of COVID-19
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory viral infections research
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Streptococcal Infections and Treatments
- Blood transfusion and management
- Advanced Chemical Sensor Technologies
- Antibiotics Pharmacokinetics and Efficacy
- Healthcare Decision-Making and Restraints
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Optical measurement and interference techniques
- Respiratory and Cough-Related Research
- Maternal and Neonatal Healthcare
- Clinical Reasoning and Diagnostic Skills
Hospital of St. Francis Xavier
2007-2025
University of Lisbon
2010-2025
Universidade Nova de Lisboa
2010-2025
Centro Hospitalar de Lisboa Ocidental
2009-2023
Instituto de Telecomunicações
2022-2023
Instituto de Investigação Científica Tropical
2023
Regional Health
2023
Public Health Department
2023
Centre Hospitalier de Douai
2021
Université de Rouen Normandie
2021
Although patients with SARS-CoV-2 infection have several risk factors for ventilator-associated lower respiratory tract infections (VA-LRTI), the reported incidence of hospital-acquired is low. We aimed to determine relationship between pneumonia, as compared influenza pneumonia or no viral infection, and VA-LRTI.Multicenter retrospective European cohort performed in 36 ICUs. All adult receiving invasive mechanical ventilation > 48 h were eligible if they had: at ICU admission. VA-LRTI,...
Patients with SARS-CoV-2 infection are at higher risk for ventilator-associated pneumonia (VAP). No study has evaluated the relationship between VAP and mortality in this population, or compared patients other populations. The main objective of our was to determine patients.Planned ancillary analysis a multicenter retrospective European cohort. diagnosed using clinical, radiological quantitative microbiological criteria. Univariable multivariable marginal Cox's regression models,...
Rationale: Early empirical antimicrobial treatment is frequently prescribed to critically ill patients with coronavirus disease (COVID-19) based on Surviving Sepsis Campaign guidelines.Objectives: We aimed determine the prevalence of early bacterial identification in intubated severe acute respiratory syndrome 2 (SARS-CoV-2) pneumonia, as compared influenza and characterize its microbiology impact outcomes.Methods: A multicenter retrospective European cohort was performed 36 ICUs. All adult...
Recent multicenter studies identified COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large study has compared the incidence of IPA between and influenza patients.To determine putative in critically ill SARS-CoV-2 patients, with patients.This was planned ancillary analysis coVAPid retrospective European cohort. Consecutive adult patients requiring mechanical ventilation > 48 h pneumonia or were included. The 28-day cumulative IPA, based on Blot definition,...
Lower respiratory tract infections (LRTI) are the most frequent infectious complication in patients admitted to intensive care unit (ICU). We aim report clinical characteristics of ICU-admitted due nosocomial LRTI and describe their microbiology outcomes.A prospective observational study was conducted 13 countries over two continents from 9th May 2016 until 16th August 2019. Characteristics outcomes ventilator-associated pneumonia (VAP), tracheobronchitis (VAT), ICU hospital-acquired...
Thrombocytopenia (platelet count < 150 × 109/L) is common in intensive care unit (ICU) patients and likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia ICU patients. We conducted a prospective cohort adult 52 ICUs across 10 countries. assessed frequencies of thrombocytopenia, use platelet transfusions clinical outcomes including mortality. evaluated pre-selected potential risk factors for the development during stay associations...
The aim of this study was to evaluate C-reactive protein (CRP) levels, body temperature and white cell count (WCC) after prescription antibiotics in order describe the clinical resolution ventilator-associated pneumonia (VAP). A cohort 47 VAP patients with microbiological confirmation disease assessed. CRP WCC were monitored daily. On day 4 antibiotic therapy, level survivors 0.62 times initial value, whereas, nonsurvivors, it 0.98. Body remained almost unchanged. By 4, a >0.6 marker poor...
Manifestations of sepsis are sensitive but poorly specific infection. Our aim was to assess the value daily measurements C-reactive protein (CRP), temperature and white cell count (WCC) in early identification intensive care unit (ICU)-acquired infections.We undertook a prospective observational cohort study (14 month). All patients admitted for > or =72 hours (n = 181) were divided into an infected 35) noninfected group 28). Infected had documented ICU-acquired infection not receiving...
The aim of the present study was to evaluate C-reactive protein level, body temperature and white cell count in patients after prescription antibiotics order describe clinical resolution severe community-acquired pneumonia.A cohort 53 consecutive with pneumonia studied. levels, were monitored daily.By day 3 a level 0.5 times initial marker poor outcome (sensitivity, 0.91; specificity, 0.59). Patients divided according their patterns response antibiotics, into fast response, slow nonresponse,...
Community-acquired pneumonia (CAP) requiring intensive care unit (ICU) admission remains a severe medical condition, presenting ICU mortality rates reaching 30%. The aim of this study was to assess the value different patterns C-reactive protein (CRP)-ratio response antibiotic therapy in patients with CAP as an early maker outcome.In total, 191 were prospectively included and CRP sampled every other day from D1 D7 prescription. CRP-ratio calculated relation concentration. Patients classified...
Abstract Background Ventilator-associated pneumonia (VAP) is associated with high morbidity and health care costs, yet diagnosis remains a challenge. Analysis of airway microbiota by amplicon sequencing provides possible solution, as characterised disruption the microbiome. However, studies evaluating diagnostic capabilities microbiome analysis are limited, lack alignment on biomarkers. Using bronchoalveolar lavage fluid (BALF) from ventilated adult patients suspected VAP, we aimed to...
Background: Nosocomial lower respiratory tract infections (nLRTIs) are associated with unfavorable clinical outcomes and significant healthcare costs. nLRTIs include hospital-acquired pneumonia (HAP), ventilator-associated (VAP), other ICU-acquired phenotypes. While risk factors for mortality in these critical to guide preventive strategies, it remains unclear whether they vary based on their requirement of invasive mechanical ventilation (IMV) at any point during the hospitalization....
The management of severe SARS-CoV-2 pneumonia, alongside logistical constraints, evolved between the first and subsequent COVID-19 waves. This study aimed to compare prevalence early bacterial pulmonary co-infections incidence ventilator-associated lower respiratory tract infections (VA-LRTI) across second waves pandemic, characterize their microbiology. Latter part a multicenter retrospective European cohort analysis conducted in 35 ICUs. Adult patients admitted for pneumonia requiring...
The aim of this planned analysis the prospective multinational TAVeM database was to determine incidence, aetiology and impact on outcome ventilator-associated lower respiratory tract infections (VA-LRTI) in immunocompromised patients.All patients receiving mechanical ventilation for >48 h were included. Immunocompromised (n=663) compared with non-immunocompromised (n=2297).The incidence VA-LRTI significantly among than (16.6% versus 24.2%; sub-hazard ratio 0.65, 95% CI 0.53-0.80; p<0.0001)....
We evaluated the usefulness of monitoring daily C-reactive protein (CRP) levels after initiation antimicrobial therapy in 44 patients with bloodstream infection. The ratio CRP level during to at start (CRP ratio) was measured. A >0.58 day 4 a marker poor outcome (sensitivity, 0.89; specificity, 0.69). recognition pattern CRP-ratio response useful prediction individual clinical course.