Fernando A. Bozza
A5076649706- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Respiratory Support and Mechanisms
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Malaria Research and Control
- Breast Cancer Treatment Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- SARS-CoV-2 and COVID-19 Research
- Family and Patient Care in Intensive Care Units
- COVID-19 epidemiological studies
- Cardiac, Anesthesia and Surgical Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac Arrest and Resuscitation
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Immune Response and Inflammation
- Anesthesia and Sedative Agents
- COVID-19 and healthcare impacts
- Breast Lesions and Carcinomas
- Inflammasome and immune disorders
- COVID-19 and Mental Health
D’Or Institute for Research and Education
2016-2025
Fundação Oswaldo Cruz
2016-2025
Instituto Estadual do Cérebro Paulo Niemeyer
2019-2025
Instituto Evandro Chagas
2015-2025
Universidade Nova de Lisboa
2024-2025
Universidade Federal Fluminense
2025
Pontifical Catholic University of Rio de Janeiro
2025
Ministério da Saúde
2018-2024
Brazilian Research in Intensive Care Network
2017-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2022
Abstract Introduction The current shortage of accurate and readily available, validated biomarkers disease severity in sepsis is an important limitation when attempting to stratify patients into homogeneous groups, order study pathogenesis or develop therapeutic interventions. aim the present was determine cytokine profile plasma with severe by using a multiplex system for simultaneous detection 17 cytokines. Methods This prospective cohort conducted four tertiary hospitals. A total 60...
Heme from red blood cells released in septic shock worsens organ dysfunction and increases the risk of death, but can be overcome by a scavenger free heme.
Abstract Background Dengue virus pathogenesis is not yet fully understood and the identification of patients at high risk for developing severe disease forms still a great challenge in dengue patient care. During present study, we evaluated prospectively potential cytokines plasma from with stratifying severity. Methods Seventeen-cytokine multiplex fluorescent microbead immunoassay was used simultaneous detection 59 patients. GLM models using bimodal or Gaussian family were determined order...
Objective: To evaluate the characteristics and outcomes of patients with cancer admitted to several intensive care units. Knowledge on requiring is mostly restricted single-center studies. Design: Prospective, multicenter, cohort study. Setting: Intensive units from 28 hospitals in Brazil. Patients: A total 717 consecutive included over a 2-mo period. Interventions: None. Measurements Main Results: There were 667 (93%) solid tumors 50 (7%) had hematologic malignancies. The main reasons for...
Blunting increased vascular permeability caused by an infection-induced cytokine storm with a Slit ligand survival in rodent models of sepsis and viral infection.
In Brief Objective: The aim of this multicenter randomized trial was to assess the efficacy and safety sentinel lymph node (SLN) biopsy compared with axillary dissection (ALND). Background: All studies on SLN in breast cancer report a variable false negative rate, whose prognostic consequences are still unclear. Methods: From May 1999 December 2004, patients ≤3 cm were randomly assigned receive associated ALND (ALND arm) or followed by only if metastatic (SLN arm). main comparison...
Viruses are obligate intracellular parasites that make use of the host metabolic machineries to meet their biosynthetic needs. Thus, identifying pathways essential for virus replication may lead potential targets therapeutic intervention. The mechanisms and explored by SARS-CoV-2 support its within cells not fully known. Lipid droplets (LD) organelles with major functions in lipid metabolism, energy homeostasis transport, have multiple roles infections inflammation. Here we described...
Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocyte death is essential for identification therapies capable to control hyper-inflammation reduce viral replication patients 2019 disease (COVID-19). Here, we show that SARS-CoV-2 engages inflammasome triggers pyroptosis human monocytes, experimentally infected,...
Abstract Objective To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast external beam radiotherapy for early cancer. Design Prospective, open label, randomised controlled clinical trial. Setting 32 centres in 10 countries the United Kingdom, Europe, Australia, States, and Canada. Participants 2298 women aged 45 years older with invasive ductal carcinoma up to 3.5 cm size, cN0-N1,...
To describe the quality of life among sepsis survivors.Secondary analyses two international, randomized clinical trials (A Controlled Comparison Eritoran and placebo in patients with Severe Sepsis [derivation cohort] PROWESS-SHOCK [validation cohort]).ICUs North South America, Europe, Africa, Asia, Australia.Adults severe sepsis. We analyzed only who were functional living at home without help before hospitalization (n = 1,143 987 from A PROWESS-SHOCK, respectively).None.In average age...
Zika virus (ZIKV) is a member of the Flaviviridae family, along with other agents clinical significance such as dengue (DENV) and hepatitis C (HCV) viruses. Since ZIKV causes neurological disorders during fetal development in adulthood, antiviral drugs are necessary. Sofosbuvir clinically approved for use against HCV targets protein that most conserved among members viral RNA polymerase. Indeed, we found sofosbuvir inhibits polymerase, targeting amino acid residues. inhibited replication...
A low-cost, equipment-free rapid antigen test distinguishes dengue virus serotypes and Zika in patient sera without detectable cross-reactivity.
Abstract Despite notable scientific and medical advances, broader political, socioeconomic behavioural factors continue to undercut the response COVID-19 pandemic 1,2 . Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel 386 academic, health, non-governmental organization, government other experts in from 112 countries territories recommend specific actions end persistent global threat public health. The developed set 41 consensus statements 57 recommendations...
<h3>Importance</h3> The effects of intensive care unit (ICU) visiting hours remain uncertain. <h3>Objective</h3> To determine whether a flexible family visitation policy in the ICU reduces incidence delirium. <h3>Design, Setting and Participants</h3> Cluster-crossover randomized clinical trial involving patients, members, clinicians from 36 adult ICUs with restricted (<4.5 per day) Brazil. Participants were recruited April 2017 to June 2018, follow-up until July 2018....
Abstract Background We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory emerging Infection Consortium (ISARIC) COVID-19 cohort, one of world's largest international, standardized data sets concerning hospitalized patients. Methods The set analysed includes patients between January 2020 2022 52 countries. investigated how symptoms on admission, co-morbidities, risk factors varied by age, sex other characteristics. used Cox...