A5080959000- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Sepsis Diagnosis and Treatment
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- Anesthesia and Neurotoxicity Research
- Vitamin C and Antioxidants Research
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Anesthesia and Sedative Agents
- Biochemical effects in animals
- Traumatic Brain Injury and Neurovascular Disturbances
- Bipolar Disorder and Treatment
- Inflammation biomarkers and pathways
- Bacterial Infections and Vaccines
- Antioxidant Activity and Oxidative Stress
- Neuropeptides and Animal Physiology
- Retinoids in leukemia and cellular processes
- Cardiac Arrest and Resuscitation
- Long-Term Effects of COVID-19
- Mitochondrial Function and Pathology
- Treatment of Major Depression
- Pneumonia and Respiratory Infections
Universidade do Extremo Sul Catarinense
2016-2025
Universidade do Sul de Santa Catarina
2015-2025
Hospital São Paulo
2013-2025
Centro Universitário do Espírito Santo
2013-2024
Brazilian Research in Intensive Care Network
2021-2024
Latin American Sepsis Institute
2018-2023
Universidade do Estado de Santa Catarina
2022
The University of Texas Health Science Center at Houston
2022
Hospital de São José
2020-2021
Universidade Federal de Santa Catarina
2015-2020
Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering neutrophil extracellular traps (NETs) have been described as important mediators of tissue damage in inflammatory diseases, we investigated whether NETs would be involved pathophysiology. A cohort 32 hospitalized with a confirmed diagnosis healthy controls were enrolled. The concentration was augmented plasma, tracheal aspirate, lung...
Objective: To evaluate the characteristics and outcomes of patients with cancer admitted to several intensive care units. Knowledge on requiring is mostly restricted single-center studies. Design: Prospective, multicenter, cohort study. Setting: Intensive units from 28 hospitals in Brazil. Patients: A total 717 consecutive included over a 2-mo period. Interventions: None. Measurements Main Results: There were 667 (93%) solid tumors 50 (7%) had hematologic malignancies. The main reasons for...
Oxidative stress plays an important role in the development of multiple organ failure and septic shock. Here we have evaluated effects a combination antioxidants (N-acetylcysteine plus deferoxamine) murine model polymicrobial sepsis induced by cecal ligation puncture (CLP).Prospective, randomized, controlled experiment.Animal basic science laboratory.Male Wistar rats, weighing 300-350 g.Rats subjected to CLP were treated with either N-acetylcysteine (20 mg/kg, 3 hrs, 6 12 18 24 hrs after...
Acute lung injury is an inflammatory condition for which treatment mainly supportive because effective therapies have not been developed. Cannabidiol, a non-psychotropic cannabinoid component of marijuana (Cannabis sativa), has potent immunosuppressive and anti-inflammatory properties. Therefore, we investigated the possible effect cannabidiol in murine model acute injury. Analysis total cells differential bronchoalveolar lavage fluid was used to characterize leukocyte migration into lungs;...
Abstract Introduction Contemporary information on mechanical ventilation (MV) use in emerging countries is limited. Moreover, most epidemiological studies ventilatory support were carried out before significant developments, such as lung protective or broader application of non-invasive (NIV). We aimed to evaluate the clinical characteristics, outcomes and risk factors for hospital mortality failure NIV patients requiring Brazilian intensive care units (ICU). Methods In a multicenter,...
The underlying mechanisms of the changes in mental status, septic encephalopathy, and long-term cognitive symptoms sepsis survivors have only been defined part. present study was undertaken to assess different variables oxidative stress several brain structures after cecal ligation perforation rat.Prospective animal study.Animal basic science laboratory.Male Wistar rats, weighing 250-350 g.Rats were subjected (sepsis group) with saline resuscitation (at 50 mL/kg immediately 12 hrs...
Sedation overuse is frequent and possibly associated with poor outcomes in the intensive care unit (ICU) patients. However, association of early oversedation clinical has not been thoroughly evaluated. The aim this study was to assess sedation strategies critically ill adult patients under mechanical ventilation (MV). A secondary analysis a multicenter prospective cohort conducted 45 Brazilian ICUs, including requiring ventilatory support first 48 hours ICU admissions, performed. depth...
Contrast-induced nephropathy (CIN) is associated with a combination of hypoxic and toxic renal tubular damage, endothelial dysfunction altered intra-renal microcirculation. Recently, sodium butyrate (SB) has been focused on since it possesses anti-inflammatory activities. Thus, based the lack information effects SB in acute kidney injury (AKI), we investigated possible after CIN rats. Wistar rats were divided into three groups: (1 sham) control, (2 MI) AKI treated contrast medium (3 MI + SB)...
Different therapies are currently used, considered, or proposed for the treatment of COVID-19; many those therapies, no appropriate assessment effectiveness and safety was performed. This document aims to provide scientifically available evidence-based information in a transparent interpretation, subsidize decisions related pharmacological therapy COVID-19 Brazil.A group 27 experts methodologists integrated task-force formed by professionals from Brazilian Association Intensive Care Medicine...