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Khiany Mathias

ORCID: 0000-0002-0067-3227
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Contact & Profiles
A5040501352
Research Areas
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Intensive Care Unit Cognitive Disorders
  • Tryptophan and brain disorders
  • Stress Responses and Cortisol
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Anesthesia and Neurotoxicity Research
  • Mitochondrial Function and Pathology
  • Respiratory Support and Mechanisms
  • Acute Ischemic Stroke Management
  • Neonatal and fetal brain pathology
  • Cannabis and Cannabinoid Research
  • Neurological Disease Mechanisms and Treatments
  • Sepsis Diagnosis and Treatment
  • Fatty Acid Research and Health
  • Neuroscience and Neuropharmacology Research
  • Heme Oxygenase-1 and Carbon Monoxide
  • Neonatal Respiratory Health Research
  • Psychedelics and Drug Studies
  • Exercise and Physiological Responses
  • IL-33, ST2, and ILC Pathways
  • Barrier Structure and Function Studies
  • Treatment of Major Depression
  • Studies on Chitinases and Chitosanases
  • Immune responses and vaccinations
  • Bipolar Disorder and Treatment

Universidade do Sul de Santa Catarina
 2017-2025

Centro Universitário do Espírito Santo
 2025

Universidade do Extremo Sul Catarinense
 2025

 Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats
OPENALEX - Publications 
Martins Back Netto Aloir Neri de Oliveira Mariana Pereira de Souza Goldim Khiany Mathias Maria Eduarda Fileti and 10 more Naiana da Rosa Ana Olívia Martins Laurentino Bianca Xavier de Farias Ana Beatriz Costa Gislaine Tezza Rezin Jucélia Jeremias Fortunato Amanda Della Giustina Tatiana Barichello Felipe Dal‐Pizzol Fabrícia Petronilho

10.1016/j.bbi.2018.07.016 article EN Brain Behavior and Immunity 2018-07-21
 Dimethyl Fumarate Modulates Oxidative Stress and Inflammation in Organs After Sepsis in Rats
OPENALEX - Publications 
Amanda Della Giustina Sandra Bonfante Graciela Freitas Zarbato Lucinéia Gainski Danielski Khiany Mathias and 8 more Aloir Neri de Oliveira Leandro Garbossa Taise Cardoso Maria Eduarda Fileti Raquel Jaconi De Carli Mariana Pereira de Souza Goldim Tatiana Barichello Fabrícia Petronilho

10.1007/s10753-017-0689-z article EN Inflammation 2017-11-09
 Vitamin B6 Reduces Neurochemical and Long-Term Cognitive Alterations After Polymicrobial Sepsis: Involvement of the Kynurenine Pathway Modulation
OPENALEX - Publications 
Lucinéia Gainski Danielski Amanda Della Giustina Mariana Pereira de Souza Goldim Driélly Florentino Khiany Mathias and 14 more Leandro Garbossa Rosiane de Bona Schraiber Ana Olívia Martins Laurentino Marina Goulart da Silva Monique Michels Karina Barbosa de Queiroz Markus Kohlhof Gislaine Tezza Rezin Jucélia Jeremias Fortunato João Quevedo Tatiana Barichello Felipe Dal‐Pizzol Roney S. Coimbra Fabrícia Petronilho

10.1007/s12035-017-0706-0 article EN Molecular Neurobiology 2017-09-06
 Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis
OPENALEX - Publications 
Amanda Della Giustina Mariana Pereira de Souza Goldim Lucinéia Gainski Danielski Driélly Florentino Khiany Mathias and 13 more Leandro Garbossa Aloir Neri de Oliveira Maria Eduarda Fileti Graciela Freitas Zarbato Naiana da Rosa Ana Olívia Martins Laurentino Jucélia Jeremias Fortunato Francielle Mina Tatiani Bellettini‐Santos Josiane Budni Tatiana Barichello Felipe Dal‐Pizzol Fabrícia Petronilho

10.1016/j.neuint.2017.06.003 article EN Neurochemistry International 2017-06-10
 Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial Sepsis
OPENALEX - Publications 
Graciela Freitas Zarbato Mariana Pereira de Souza Goldim Amanda Della Giustina Lucinéia Gainski Danielski Khiany Mathias and 12 more Driélly Florentino Aloir Neri de Oliveira Naiana da Rosa Ana Olívia Martins Laurentino Taina Trombetta Maria Luiza Pessanha Menezes Gomes Amanda V. Steckert Ana Paula Moreira Patrícia Fernanda Schuck Jucélia Jeremias Fortunato Tatiana Barichello Fabrícia Petronilho

10.1007/s12640-018-9900-8 article EN Neurotoxicity Research 2018-04-30
 Ayahuasca reverses ischemic stroke-induced neuroinflammation and oxidative stress
OPENALEX - Publications 
Larissa Joaquim Lara Rodrigues da Rosa Yasmin Strickert Richard Simon Machado Everton Lanzzarin and 21 more Gabriela Bernardes Suelen de Souza Ramos Linério Ribeiro de Novais Beatriz Steiner Brenno Farias Khiany Mathias Helena Martins E. Lins Jéssica Schaefer Chaves Douglas Camilo Larissa Espindola da Silva Mariana Pacheco de Oliveira Mariella Reinol da Silva Pablo Michel Pereira Barcelos Fabiana Pereira Santos Franciane Bobinski Gislaine Tezza Rezin Maurı́cio Yonamine Antonio Inserra Fabrícia Petronilho Rafael Mariano de Bitencourt

10.1016/j.bbr.2025.115521 article EN Behavioural Brain Research 2025-03-01
 Cannabidiol reverses myeloperoxidase hyperactivity in the prefrontal cortex and striatum, and reduces protein carbonyls in the hippocampus in a ketamine-induced schizophrenia rat model
OPENALEX - Publications 
Sofia de Almeida Queiroz Linério Ribeiro de Novais Júnior ANITA PACHECO Tiago Vicente da Silva Suelen de Souza Ramos and 9 more Vicente Meneguzzo Khiany Mathias Anita Dal Bó Tiscoski N. Piacentini Mariana Pereira de Souza Goldim Betine Pinto Moehlecke Iser Fabrícia Petronilho Antonio Inserra Rafael Mariano de Bitencourt

10.1016/j.schres.2025.03.031 article EN Schizophrenia Research 2025-03-25
 Hyperoxia and brain: the link between necessity and injury from a molecular perspective
OPENALEX - Publications 
Richard Simon Machado Khiany Mathias Larissa Joaquim Rafaella Willig de Quadros Gislaine Tezza Rezin and 1 more Fabrícia Petronilho

10.1007/s12640-024-00702-6 article EN Neurotoxicity Research 2024-04-01
 Sepsis compromises post-ischemic stroke neurological recovery and is associated with sex differences
OPENALEX - Publications 
Larissa Joaquim Beatriz Steiner Brenno Farias Richard Simon Machado Lucinéia Gainski Danielski and 17 more Khiany Mathias Solange Stork Everton Lanzzarin L.C.L. Novaes Sandra Bonfante Jaqueline S. Generoso Carolina Giassi Alano Isabela da Silva Lemos Diogo Dominguini Amanda Della Giustina Carlos Henrique Rocha Catalão Emílio L. Streck Vijayasree V. Giridharan Felipe Dal‐Pizzol Tatiana Barichello Rafael Mariano de Bitencourt Fabrícia Petronilho

10.1016/j.lfs.2024.122721 article EN Life Sciences 2024-05-15
 Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats dependent on NLRP3 activation
OPENALEX - Publications 
Sandra Bonfante Martins Back Netto Aloir Neri de Oliveira Khiany Mathias Richard Simon Machado and 17 more Larissa Joaquim Taina Cidreira Marina Goulart da Silva Guilherme Cabreira Daros Lucinéia Gainski Danielski Fernanda Gava Isabela da Silva Lemos Rafaela Tezza Matiola Emily Córneo Josiane Somariva Prophiro Rafael Mariano de Bitencourt Carlos Henrique Rocha Catalão Jaqueline S. Generoso Emílio L. Streck Felipe Dal‐Pizzol Tatiana Barichello Fabrícia Petronilho

10.1007/s11011-024-01425-5 article EN Metabolic Brain Disease 2024-11-13
 Ayahuasca Pretreatment Prevents Sepsis-Induced Anxiety-Like Behavior, Neuroinflammation, and Oxidative Stress, and Increases Brain-Derived Neurotrophic Factor
OPENALEX - Publications 
Rick Wilhiam de Camargo Larissa Joaquim Richard Simon Machado Suelen de Souza Ramos Lara Rodrigues da Rosa and 23 more Linério Ribeiro de Novais Khiany Mathias Lara Maximiano Yasmin Strickert Rafael Nord Maria Laura Gava Eduarda Scarpari Helena Martins E. Lins Jéssica Schaefer Chaves Larissa Espindola da Silva Mariana Pacheco de Oliveira Mariella Reinol da Silva Bruna Barros Fernandes Anita Dal Bó Tiscoski N. Piacentini Fabiana Pereira Santos Antonio Inserra Franciane Bobinski Gislaine Tezza Rezin Maurı́cio Yonamine Fabrícia Petronilho Rafael Mariano de Bitencourt

10.1007/s12035-024-04597-4 article EN Molecular Neurobiology 2024-11-30
 Acute treatment with ketamine and chronic treatment with minocycline exert antidepressant-like effects and antioxidant properties in rats subjected different stressful events
OPENALEX - Publications 
Amanda L. Maciel Helena M. Abelaira Airam B. de Moura Thays G. de Souza Thayse Rosa and 10 more Danyela Matos Talita Tuon Leandro Garbossa Ana Paula Strassi Maria Eduarda Fileti Mariana Pereira de Souza Goldim Khiany Mathias Fabrícia Petronilho João Quevedo Gislaine Z. Réus

10.1016/j.brainresbull.2017.12.005 article EN Brain Research Bulletin 2017-12-15
 Acute and chronic treatment with quetiapine induces antidepressant-like behavior and exerts antioxidant effects in the rat brain
OPENALEX - Publications 
Zuleide Maria Ignácio Gislaine Z. Réus Helena M. Abelaira Airam B. de Moura Thays G. de Souza and 6 more Danyela Matos Mariana Pereira de Souza Goldim Khiany Mathias Leandro Garbossa Fabrícia Petronilho João Quevedo

10.1007/s11011-017-0028-y article EN Metabolic Brain Disease 2017-05-05
 Fish oil–rich lipid emulsion modulates neuroinflammation and prevents long-term cognitive dysfunction after sepsis
OPENALEX - Publications 
Amanda Della Giustina Mariana Pereira de Souza Goldim Lucinéia Gainski Danielski Driélly Florentino Leandro Garbossa and 17 more Larissa Joaquim Aloir Neri de Oliveira Khiany Mathias Maria Eduarda Fileti Graciela Freitas Zarbato Naiana da Rosa Ana Olívia Martins Laurentino Jucélia Jeremias Fortunato Juliete Palandi Bruna Hoffmann de Oliveira Daniel Fernandes Martins Franciane Bonbinski Tatiani Bellettini‐Santos Michelle Lima Garcez Josiane Budni Tatiana Barichello Fabrícia Petronilho

10.1016/j.nut.2018.12.003 article EN Nutrition 2018-12-07
 Folic acid alleviates the blood brain barrier permeability and oxidative stress and prevents cognitive decline in sepsis-surviving rats
OPENALEX - Publications 
MICHELE M. NOVOCHADLO Mariana Pereira de Souza Goldim Sandra Bonfante Larissa Joaquim Khiany Mathias and 12 more Kiuanne Lino Lobo Metzker Richard Simon Machado Everton Lanzzarin Gabriela Bernades Érick Bagio Leandro Garbossa Aloir Neri de Oliveira Naiana da Rosa Jaqueline S. Generoso Jucélia Jeremias Fortunato Tatiana Barichello Fabrícia Petronilho

10.1016/j.mvr.2021.104193 article EN Microvascular Research 2021-05-29
 NLRP3 inflammasome activation increases brain oxidative stress after transient global cerebral ischemia in rats
OPENALEX - Publications 
Larissa Joaquim Lucinéia Gainski Danielski Sandra Bonfante Erica Biehl Khiany Mathias and 9 more Taís Luise Denicol Érick Bagio Everton Lanzzarin Richard Simon Machado Gabriela Bernades Jaqueline S. Generoso Amanda Della Giustina Tatiana Barichello Fabrícia Petronilho

Oxidative stress has been reported to be an important mechanism for brain damage following ischemic stroke. Recently, the involvement of cytosolic receptors capable forming protein complexes called inflammasomes demonstrated perpetuate oxidative stress. Herein, we report effect NLRP3 inhibition with MCC950 on in animal model transient global cerebral ischemia.

10.1080/00207454.2021.1922402 article EN International Journal of Neuroscience 2021-04-27
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