A5063336320- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neuropharmacology Research
- Muscle metabolism and nutrition
- Alcoholism and Thiamine Deficiency
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Amino Acid Enzymes and Metabolism
- Biochemical Acid Research Studies
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Antioxidant Activity and Oxidative Stress
- Pharmacological Effects and Toxicity Studies
- Folate and B Vitamins Research
- Free Radicals and Antioxidants
- Genetic Neurodegenerative Diseases
- Cholinesterase and Neurodegenerative Diseases
- Fatty Acid Research and Health
- Coenzyme Q10 studies and effects
- Stress Responses and Cortisol
- RNA regulation and disease
- Diet, Metabolism, and Disease
- Retinoids in leukemia and cellular processes
Universidade Federal do Rio de Janeiro
2015-2025
Pontifícia Universidade Católica do Rio Grande do Sul
2018-2020
Universidade do Extremo Sul Catarinense
2010-2019
University of Rio Grande and Rio Grande Community College
2019
Universidade do Sul de Santa Catarina
2014-2018
University of Maryland, Baltimore
2018
Universidade Federal do Rio Grande do Sul
2002-2012
Universidade Federal de Ciências da Saúde de Porto Alegre
2003-2009
Universidade Luterana do Brasil
2003
Patients affected by maple syrup urine disease (MSUD) present severe neurological symptoms and brain abnormalities, whose pathophysiology is poorly known. In the study we investigated in vitro effects of leucine (Leu), alpha-ketoisocaproic acid (KIC) alpha-hydroxyisovaleric (HIV), respectively, branched-chain amino, keto hydroxy acids that most accumulate MSUD, on bioenergetic homeostasis, evaluating respiratory parameters obtained oxygen consumption, membrane potential (Psim), NAD(P)H...
Tyrosinemia is a rare genetic disease caused by mutations on genes that codify enzymes responsible for tyrosine metabolism. Considering tyrosinemics patients usually present symptoms associated with central nervous system alterations ranges from slight decreases in intelligence to severe mental retardation, we decided investigate whether acute and chronic administration of L-tyrosine rats would affect acetylcholinesterase mRNA expression enzymatic activity during their development. In our...
Depressive disorders, including major depression, are serious and disabling for affected patients. Although the neurobiological understanding of depressive disorder focuses mainly on monoamine hypothesis, exact pathophysiology depression is not fully understood.Animals received daily intra-peritoneal injections paroxetine (10 mg/kg), nortriptyline (15 mg/kg) or venlafaxine in 1.0 ml/kg volume 15 days. Twelve hours after last injection, rats were killed by decapitation, where brain was...