Renê Donizeti Ribeiro de Oliveira
A5078765495- Rheumatoid Arthritis Research and Therapies
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Long-Term Effects of COVID-19
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Lymphocytic Leukemia Research
- Metabolomics and Mass Spectrometry Studies
- Cell Adhesion Molecules Research
- Oral microbiology and periodontitis research
- Autoimmune and Inflammatory Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- Dermatological and COVID-19 studies
- Osteoarthritis Treatment and Mechanisms
- Lipoproteins and Cardiovascular Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral Infections and Immunology Research
- Tuberculosis Research and Epidemiology
- IL-33, ST2, and ILC Pathways
- Vasculitis and related conditions
- Oral Health Pathology and Treatment
Universidade de São Paulo
2015-2024
Universidade de Ribeirão Preto
2017-2024
Universidade Federal de Minas Gerais
2014-2023
Clinics Hospital of Ribeirão Preto
2019-2022
United Nations Industrial Development Organization
2014
University of Glasgow
2014
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2012
Hospital de Clínicas
2012
Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering neutrophil extracellular traps (NETs) have been described as important mediators of tissue damage in inflammatory diseases, we investigated whether NETs would be involved pathophysiology. A cohort 32 hospitalized with a confirmed diagnosis healthy controls were enrolled. The concentration was augmented plasma, tracheal aspirate, lung...
Severe cases of COVID-19 are characterized by a strong inflammatory process that may ultimately lead to organ failure and patient death. The NLRP3 inflammasome is molecular platform promotes inflammation via cleavage activation key molecules including active caspase-1 (Casp1p20), IL-1β, IL-18. Although participation the in has been highly speculated, outcome disease unknown. Here we demonstrate activated response SARS-CoV-2 infection patients. Studying moderate severe patients, found PBMCs...
Objective To evaluate whether the addition of colchicine to standard treatment for COVID-19 results in better outcomes. Design We present a randomised, double-blinded, placebo-controlled clinical trial moderate severe COVID-19, with 75 patients allocated 1:1 from 11 April 30 August 2020. Colchicine regimen was 0.5 mg thrice daily 5 days, then twice days. The primary endpoints were need supplemental oxygen, time hospitalisation, admission and length stay intensive care unit death rate....
Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, long-term dysfunction (recently characterized as part of "long COVID-19" syndrome) has been frequently observed after mild infection. We show the spectrum cerebral impact acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranging from alterations in mildly infected individuals (orbitofrontal cortical atrophy, neurocognitive impairment, excessive fatigue and anxiety...
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by joint destruction and severe morbidity. Methotrexate (MTX) the standard first-line therapy of RA. However, about 40% RA patients are unresponsive to MTX treatment. Regulatory T cells (Tregs, CD4(+)CD25(+)FoxP3(+)) thought play important role in attenuating To investigate Tregs resistance, we recruited 122 (53 responsive, R-MTX; 69 unresponsive, UR-MTX) 33 healthy controls. Three months after treatment, R-MTX but...
Objective Infiltration of neutrophils into the joints plays an important role in bone erosion and articular destruction rheumatoid arthritis (RA). Neutrophil trafficking during inflammation is a process that involves activation chemotactic receptors. Recent findings suggest changes receptor patterns could occur under certain inflammatory conditions. The aim this study was to evaluate gain responsiveness CCL2 RA patients assess driving neutrophil infiltration joints. Methods Neutrophils were...
Abstract Background The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases COVID-19. However, the molecular mechanisms underlying NETs COVID-19 remain unclear. Objectives We aim to investigate role Gasdermin-D (GSDMD) pathway on development during Methods performed a single-cell transcriptome analysis public data bronchoalveolar lavage. Then, we enrolled 63 hospitalized patients moderate analyze blood lung...
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a hyperinflammatory state and lymphocytopenia, hallmark that appears as both signature prognosis of disease severity outcome. Although cytokine storm sustained inflammatory are commonly immune cell depletion, it still unclear whether direct SARS-CoV-2 cells could also play role in this scenario by harboring viral replication. We found monocytes, well B T lymphocytes, were susceptible to...
Occurrence of hyperglycemia upon infection is associated with worse clinical outcome in COVID-19 patients. However, it still unknown whether SARS-CoV-2 directly triggers hyperglycemia. Herein, we interrogated and how causes by infecting hepatocytes increasing glucose production. We performed a retrospective cohort study including patients that were admitted at hospital suspicion COVID-19. Clinical laboratory data collected from the chart records daily blood values analyzed to test hypothesis...
Abstract Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, the long-term dysfunction has been frequently observed after mild infection. Here we show spectrum of cerebral impact SARS-CoV-2 infection ranging from alterations in mildly infected individuals (orbitofrontal cortical atrophy, neurocognitive impairment, excessive fatigue and anxiety symptoms) to acute damage confirmed brain tissue samples extracted orbitofrontal...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces mild or asymptomatic COVID-19 in most cases, but some patients develop an excessive inflammatory process that can be fatal. As the NLRP3 inflammasome and additional inflammasomes are implicated disease aggravation, drug repositioning to target emerges as a strategy treat COVID-19. Here, we performed high-throughput screening using 2560 small-molecule compound library identified FDA-approved drugs function pan-inflammasome...
Epidemiologic studies have highlighted the association of environmental factors with development and progression autoimmune chronic inflammatory diseases. Among factors, smoking has been associated increased susceptibility poor prognosis in rheumatoid arthritis (RA). However, immune molecular mechanism smoking-induced aggravation remains unclear. The transcription factor aryl hydrocarbon receptor (AHR) regulates generation Th17 cells, CD4 T cells linked AHR is activated by organic compounds...
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint destruction and severe morbidity. Cigarette smoking (CS) can exacerbate the incidence severity of RA. Although Th17 cells Aryl hydrocarbon receptor (AhR) have been implicated, mechanism which CS induces RA development remains unclear. Here, using transcriptomic analysis, we show that microRNA-132 specifically induced in presence either AhR agonist or CS-enriched medium. miRNA-132 thus packaged into...
Abstract Background and Purpose Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause bone erosion due to increased osteoclastogenesis. Neutrophils involvement in osteoclastogenesis remains uncertain. Given neutrophil extracellular traps (NETs) act as inflammatory mediators rheumatoid arthritis, we investigated the role of NETs stimulating loss by potentiating during arthritis. Experimental Approach The level synovial fluid from patients was assessed. Bone evaluated...
Abstract This study evaluated the role of macrophage migration inhibitory factor in inflammation caused by monosodium urate crystals. The concentration was increased synovial fluid patients with acute gout, and there a positive correlation between intra-articular IL-1β concentrations. In mice, injection crystals into knee joint levels macrophages inflamed tissue. recombinant mice reproduced inflammatory response observed including histologic changes, recruitment neutrophils, CXCL1....
Purpose: This study aimed to culturally adapt and validate the Revised Fibromyalgia Impact Questionnaire (FIQR) Brazilian Portuguese, by use of analysis internal consistency, reliability, construct structural validity.Method: A total 100 female patients with fibromyalgia participated in validation process Portuguese version FIQR (FIQR-Br).The intraclass correlation coefficient (ICC) was used for statistical reliability (test–retest), Cronbach's alpha Pearson's rank validity, confirmatory...
Abstract Objective To evaluate the role of neutrophil extracellular traps (NETs) in genesis joint hyperalgesia using an experimental model arthritis and transpose findings to clinical investigation. Methods C57BL/6 mice were subjected antigen-induced (AIA) treated with Pulmozyme (PLZ) degrade NETs or Cl-amidine inhibit NET production. Oedema formation, histopathological score mechanical evaluated. injected intra-articularly wild type (WT), Tlr4−/−, Tlr9−/−, Tnfr1−/− Il1r−/− mice, levels...
Abstract Objectives Neutrophil extracellular traps (NETs) play a role in the pathogenesis of periodontitis and rheumatoid arthritis (RA). However, it remains poorly understood whether NETs participate cross-talk between RA. Herein, we investigated production individuals with RA its association clinical parameters. The impact periodontal therapy on NET release was also assessed. Methods concentration cytokines determined saliva plasma early (n = 24), established 64) without 76). influence...