A5001247661- Pain Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Treatment and Pharmacology
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Inflammasome and immune disorders
- Adenosine and Purinergic Signaling
- Transcranial Magnetic Stimulation Studies
- Perfectionism, Procrastination, Anxiety Studies
- Peroxisome Proliferator-Activated Receptors
- Restless Legs Syndrome Research
- S100 Proteins and Annexins
- Seaweed-derived Bioactive Compounds
- Echinoderm biology and ecology
- Pediatric Pain Management Techniques
- Cannabis and Cannabinoid Research
- Sleep and Wakefulness Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Nerve injury and regeneration
- Immune Cell Function and Interaction
Universidade de São Paulo
2019-2022
Low molecular weight carrageenan (Cg) is a seaweed-derived sulfated polysaccharide widely used as inflammatory stimulus in preclinical studies. However, the mechanisms of Cg-induced inflammation are not fully elucidated. The present study aimed to investigate basis involved macrophages activation and cytokines production.Primary culture mouse peritoneal were stimulated with Kappa Cg. supernatant cell lysate for ELISA, western blotting, immunofluorescence. colitis was also developed.Here we...
Natural or synthetic ligands for peroxisome proliferator-activated receptor gamma (PPAR-γ) represent an interesting tool pharmacological interventions to treat inflammatory conditions. In particular, PPAR-γ activation prevents pain and inflammation in the temporomandibular joint (TMJ) by decreasing cytokine release stimulating synthesis of endogenous opioids. The goal this study was clarify whether induces macrophage polarization, inhibiting leukocyte recruitment. addition, we investigated...
Abstract Objective To evaluate the role of neutrophil extracellular traps (NETs) in genesis joint hyperalgesia using an experimental model arthritis and transpose findings to clinical investigation. Methods C57BL/6 mice were subjected antigen-induced (AIA) treated with Pulmozyme (PLZ) degrade NETs or Cl-amidine inhibit NET production. Oedema formation, histopathological score mechanical evaluated. injected intra-articularly wild type (WT), Tlr4−/−, Tlr9−/−, Tnfr1−/− Il1r−/− mice, levels...
Neuropathic pain is one of the most important clinical consequences injury to somatosensory system. Nevertheless, critical pathophysiological mechanisms involved in neuropathic development are poorly understood. In this study, we found that abrogated when kynurenine metabolic pathway (KYNPATH) initiated by enzyme indoleamine 2,3-dioxygenase 1 (IDO1) ablated pharmacologically or genetically. Mechanistically, it was IDO1-expressing dendritic cells (DCs) accumulated dorsal root leptomeninges...
Abstract Cytotoxic agents synergize with immune checkpoint inhibitors and improve outcomes for patients several cancer types. Nonetheless, a parallel increase in the incidence of dose-limiting side effects, such as peripheral neuropathy, is often observed. Here, we investigated role programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis modulation paclitaxel-induced neuropathic pain. We found that human mouse neural tissues, including dorsal root ganglion (DRG), expressed...
Abstract Neuroimmune interactions across the pain pathway play a predominant role in development of neuropathic pain. Previous reports demonstrated that complement driven effector systems including C5a/C5aR1 axis contribute to these neuro-immune mechanisms. However, cellular and molecular mechanisms underlying signaling-mediated remain ill-identified. Here we show following peripheral nerve injury was attenuated C5aR1-deficient male female mice as well wild type treated with selective...
Supplementary Data from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling
Background: Carrageenan (Cg) is a seaweed-derived sulfated polysaccharide widely used as food additive with the inflammatory property. However, molecular mechanisms of Cg-induced inflammation are not fully elucidated. The present study aimed to investigate IL-1β production depends on TLR4/TRIF cascade and subsequent NLRP3 inflammasome activation.Methods: undergoing in which Cg-mediated macrophages activation were determined by ELISA, Pharmacological approachs immunolabeling assay. expression...
<div>Abstract<p>Cytotoxic agents synergize with immune checkpoint inhibitors and improve outcomes for patients several cancer types. Nonetheless, a parallel increase in the incidence of dose-limiting side effects, such as peripheral neuropathy, is often observed. Here, we investigated role programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis modulation paclitaxel-induced neuropathic pain. We found that human mouse neural tissues, including dorsal root ganglion...
Supplementary Figure from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling
Supplementary Data from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling
<div>Abstract<p>Cytotoxic agents synergize with immune checkpoint inhibitors and improve outcomes for patients several cancer types. Nonetheless, a parallel increase in the incidence of dose-limiting side effects, such as peripheral neuropathy, is often observed. Here, we investigated role programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis modulation paclitaxel-induced neuropathic pain. We found that human mouse neural tissues, including dorsal root ganglion...
Supplementary Figure from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling
Neuropathic pain is triggered by injury to the somatosensory system, and one of most important types chronic pain. Nevertheless, critical pathophysiological mechanisms that maintain neuropathic are poorly understood. Here, we show abrogated when kynurenine metabolic pathway (KYNPATH) initiated enzyme indoleamine 2,3-dioxygenase (IDO) ablated pharmacologically or genetically. Mechanistically, it was found IDO upregulation in dendritic cells accumulate dorsal root leptomeninges led increased...