A5051765641- Immune cells in cancer
- Cancer Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Pain Mechanisms and Treatments
- Immune Response and Inflammation
- Cancer Treatment and Pharmacology
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- Computational Fluid Dynamics and Aerodynamics
- Heart Rate Variability and Autonomic Control
- Vagus Nerve Stimulation Research
- Immunotherapy and Immune Responses
- Mosquito-borne diseases and control
- Plant Toxicity and Pharmacological Properties
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- HIV Research and Treatment
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Neuroscience of respiration and sleep
- Fungal Infections and Studies
- Neutropenia and Cancer Infections
- Advanced Aircraft Design and Technologies
- Wildlife-Road Interactions and Conservation
- Fibroblast Growth Factor Research
Universidade de São Paulo
2016-2025
Universidade de Ribeirão Preto
2022
Universidade Federal de Minas Gerais
2016
Universidade Federal de Pelotas
2012
Universidade Federal do Espírito Santo
2011
Abstract Paclitaxel is an antineoplastic agent widely used to treat several solid tumor types. The primary mechanism of action paclitaxel based on microtubule stabilization inducing cell-cycle arrest. Here, we use models show that not only induces arrest, but also promotes antitumor immunity. In vitro, reprogrammed M2-polarized macrophages the M1-like phenotype in a TLR4-dependent manner, similarly LPS. modulated tumor-associated macrophage (TAM) profile mouse breast and melanoma tumors;...
Inflammation is a key feature of aldosterone-induced vascular damage and dysfunction, but molecular mechanisms by which aldosterone triggers inflammation remain unclear. The NLRP3 inflammasome pivotal immune sensor that recognizes endogenous danger signals triggering sterile inflammation.We analyzed function inflammatory profile wild-type (WT), knockout (NLRP3-/-), caspase-1 (Casp-1-/-), interleukin-1 receptor (IL-1R-/-) mice treated with vehicle or (600 µg·kg-1·d-1 for 14 days through...
ABSTRACT Rheumatoid arthritis is a chronic inflammatory disease that leads to significant changes in metabolic activity. Succinate, an intermediate of the tricarboxylic acid cycle, has emerged as mediator innate immune response. However, involvement succinate generation adaptive response and establishment autoimmune not been addressed thus far. Here we demonstrated succinate‐sensing receptor (Sucnr1/GPR91) plays critical role development immune‐mediated arthritis. We found Sucnr1 acts...
Sepsis is a systemic inflammatory response syndrome (SIRS) resulting from severe infection that characterized by immune dysregulation, cardiovascular derangements, and end-organ dysfunction. The modification of proteins O-linked N-acetylglucosamine (O-GlcNAcylation) influences many the key processes are altered during sepsis, including production mediators vascular contractility. Here, we investigated whether O-GlcNAc affects dysfunction associated with sepsis. Mice received an...
Macrophages play a crucial role in immune responses and undergo metabolic reprogramming to fulfill their functions. The tetramerization of the glycolytic enzyme pyruvate kinase M2 (PKM2) induces production anti-inflammatory cytokine interleukin (IL)-10 vivo, but underlying mechanism remains elusive. Here, we report that PKM2 activation with pharmacological agent TEPP-46 increases IL-10 LPS-activated macrophages by reprogramming, leading release ATP from glycolysis. effect is abolished...
Abstract Macrophages are highly plastic cells, responding to diverse environmental stimuli acquire different functional phenotypes. Signaling through MAPKs has been reported regulate the differentiation of macrophages, but role ERK5 in IL-4-mediated M2 macrophage is still unclear. Here, we showed that signaling pathway plays a critical IL-4-induced differentiation. Pharmacologic inhibition MEK5, an upstream activator ERK5, markedly reduced expression classical markers, such as Arg-1, Ym-1,...
Production of nitric oxide (NO) has been demonstrated in several malignancies, however its role remains not fully understood, specifically relation to the metabolic and functional implications that it may have on immune cells participating tumorigenesis. Here, we show inducible NO synthase (iNOS) is expressed cancers colon prostate, mainly by tumour cells, generation evidenced widespread nitrotyrosine (NT) staining tissue. Furthermore, presence NT observed majority tumour-associated...
Rocio virus (ROCV) was the causative agent of an unprecedented outbreak encephalitis during 1970s in Vale do Ribeira, Sao Paulo State, Southeast region Brazil. Surprisingly, no further cases ROCV infection were identified after this outbreak; however, serological surveys have suggested circulation among humans and animals different regions Cross-protective immunity flaviviruses is well documented; consequently, induced by infections with other endemic to Brazil could potentially be...
Rocio virus (ROCV) is a highly neuropathogenic mosquito-transmitted flavivirus responsible for an unprecedented outbreak of human encephalitis during 1975–1976 in Sao Paulo State, Brazil. Previous studies have shown increased number inflammatory macrophages the central nervous system (CNS) ROCV-infected mice, implying role pathogenesis ROCV. Here, we show that ROCV infection results expression CCL2 blood and infiltration into brain. Moreover, show, using CCR2 knockout essential macrophage...
Muscle tissue damage is one of the local effects described in bothropic envenomations. Bothropstoxin-I (BthTX-I), from Bothrops jararacussu venom, a K49-phospholipase A2 (PLA2) that induces massive muscle injury, and, consequently, inflammatory reaction. The NLRP3 inflammasome sensor triggers inflammation by activating caspase 1 and releasing interleukin (IL)-1β and/or inducing pyroptotic cell death response to damage. We, therefore, aimed address activation BthTX-I-associated injury...
Abstract Cytotoxic agents synergize with immune checkpoint inhibitors and improve outcomes for patients several cancer types. Nonetheless, a parallel increase in the incidence of dose-limiting side effects, such as peripheral neuropathy, is often observed. Here, we investigated role programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis modulation paclitaxel-induced neuropathic pain. We found that human mouse neural tissues, including dorsal root ganglion (DRG), expressed...
Purpose Some first-line cytotoxic chemotherapics, e.g. doxorubicin, paclitaxel and oxaliplatin, induce activation of the immune system through immunogenic cell death (ICD). Tumor cells undergoing ICD function as a vaccine, releasing damage-associated molecular patterns (DAMPs), which act adjuvants, neoantigens tumor are recognized antigens. induction is rare, however it yields better long-lasting antitumor responses to chemotherapy. Advanced metastatic melanoma (AMM) incurable for more than...
The present study examined the hemodynamics [arterial pressure (AP), AP variability (APV), heart rate (HR), and (HRV)], cardiac function (echocardiographycally), myocardial inflammation in Balb/c mice submitted to Periodontitis, through ligation of left first molar, or Sham surgical procedure. protocol indicated that was similar (136 ± 2 vs. 132 3 mmHg Sham), while HR higher with Periodontitis (475 20 412 18 bpm compared their counterparts. APV when evaluated time domain (4.5 0.3 3.4 0.2...
Diagnosis of leptospirosis by PCR is hampered due to the presence substances on biological fluids. Here, we report an immunomagnetic separation step prior which improved detection Leptospira spp. in blood and urine samples from dogs. It resulted a significant improvement sensitivity for diagnosis canine leptospirosis.
Supplementary Data from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling
Ethnopharmacological relevance: Gout is an inflammatory disease characterized by the accumulation of monosodium urate (MSU) crystals in joints, leading to severe pain and inflammation. Natural products are important source for drug discoveries, many alkaloids isolated from these products, such as stephalagine, have been described with antinociceptive properties. Stephalagine a Brazilian Savanna aporphine alkaloid Annona crassiflora Mart. fruit peel, which has popularly used treat rheumatism....