A5049092522- Pain Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Treatment and Pharmacology
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Protease and Inhibitor Mechanisms
- Calpain Protease Function and Regulation
- Tryptophan and brain disorders
- Alcohol Consumption and Health Effects
- Neuropeptides and Animal Physiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Eicosanoids and Hypertension Pharmacology
- Science and Education Research
- Women's cancer prevention and management
- Atherosclerosis and Cardiovascular Diseases
- Adolescent Sexual and Reproductive Health
- Nitric Oxide and Endothelin Effects
- Signaling Pathways in Disease
- Aortic aneurysm repair treatments
Universidade de São Paulo
2018-2023
Resident macrophages are distributed across all tissues and highly heterogeneous due to adaptation different tissue-specific environments. The resident of the sensory ganglia (sensory neuron-associated macrophages, sNAMs) in close contact with cell body primary neurons might play physiological pathophysiological roles. After peripheral nerve injury, there is an increase population ganglia, which have been implicated conditions, including neuropathic pain development. However, it still under...
Inflammatory pain, such as hypersensitivity resulting from surgical tissue injury, occurs a result of interactions between the immune and nervous systems with orchestrated recruitment activation tissue-resident circulating cells to site injury. Our previous studies identified central role for Ly6Clow myeloid in pathogenesis postoperative pain. We now show that chemokines CCL17 CCL22, their cognate receptor CCR4, are key mediators this response. Both up-regulated early after injury by...
Neuropathic pain is one of the most important clinical consequences injury to somatosensory system. Nevertheless, critical pathophysiological mechanisms involved in neuropathic development are poorly understood. In this study, we found that abrogated when kynurenine metabolic pathway (KYNPATH) initiated by enzyme indoleamine 2,3-dioxygenase 1 (IDO1) ablated pharmacologically or genetically. Mechanistically, it was IDO1-expressing dendritic cells (DCs) accumulated dorsal root leptomeninges...
Abstract Cytotoxic agents synergize with immune checkpoint inhibitors and improve outcomes for patients several cancer types. Nonetheless, a parallel increase in the incidence of dose-limiting side effects, such as peripheral neuropathy, is often observed. Here, we investigated role programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis modulation paclitaxel-induced neuropathic pain. We found that human mouse neural tissues, including dorsal root ganglion (DRG), expressed...
Overexpression of the inducible isoform enzyme nitric oxide synthase (iNOS) has been associated to pathological processes in kidney. Ethanol consumption induces renal expression iNOS; however, contribution this deleterious effects ethanol kidney remains elusive. We examined whether iNOS plays a role dysfunction and oxidative stress induced by consumption. With purpose, male C57BL/6 wild-type (WT) or iNOS-deficient (iNOS-/-) mice were treated with (20% v/v) for 10 weeks. Treatment increased...
Abstract Resident macrophages are distributed across all tissues and highly heterogeneous as a consequence of adaptation to different tissue-specific environments. The resident the sensory ganglia (sensory neuron-associated macrophages, sNAMs) in close contact with cell body primary neurons might play physiological pathophysiological roles. After peripheral nerve injury, there is an increase population which have been involved conditions, especially neuropathic pain development regeneration....
Supplementary Data from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling
<div>Abstract<p>Cytotoxic agents synergize with immune checkpoint inhibitors and improve outcomes for patients several cancer types. Nonetheless, a parallel increase in the incidence of dose-limiting side effects, such as peripheral neuropathy, is often observed. Here, we investigated role programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis modulation paclitaxel-induced neuropathic pain. We found that human mouse neural tissues, including dorsal root ganglion...
Supplementary Figure from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling
Supplementary Data from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling
<div>Abstract<p>Cytotoxic agents synergize with immune checkpoint inhibitors and improve outcomes for patients several cancer types. Nonetheless, a parallel increase in the incidence of dose-limiting side effects, such as peripheral neuropathy, is often observed. Here, we investigated role programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis modulation paclitaxel-induced neuropathic pain. We found that human mouse neural tissues, including dorsal root ganglion...
Supplementary Figure from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling
Neuropathic pain is triggered by injury to the somatosensory system, and one of most important types chronic pain. Nevertheless, critical pathophysiological mechanisms that maintain neuropathic are poorly understood. Here, we show abrogated when kynurenine metabolic pathway (KYNPATH) initiated enzyme indoleamine 2,3-dioxygenase (IDO) ablated pharmacologically or genetically. Mechanistically, it was found IDO upregulation in dendritic cells accumulate dorsal root leptomeninges led increased...