A5088542721- Alcohol Consumption and Health Effects
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Gut microbiota and health
- Advanced Glycation End Products research
- Systemic Lupus Erythematosus Research
- Renal function and acid-base balance
- Vector-borne infectious diseases
- Hemodynamic Monitoring and Therapy
- Receptor Mechanisms and Signaling
- Hormonal and reproductive studies
- Cannabis and Cannabinoid Research
- Traditional and Medicinal Uses of Annonaceae
- Stress Responses and Cortisol
- Atherosclerosis and Cardiovascular Diseases
- Renin-Angiotensin System Studies
- Cardiovascular Disease and Adiposity
- Essential Oils and Antimicrobial Activity
- Sexual function and dysfunction studies
- Safe Handling of Antineoplastic Drugs
- Diet and metabolism studies
- Pharmaceutical studies and practices
- Pharmacogenetics and Drug Metabolism
- Calpain Protease Function and Regulation
- Calcium signaling and nucleotide metabolism
Universidade de São Paulo
2019-2025
Universidade de Ribeirão Preto
2019-2022
SUPERA Park of Innovation and Technology of Ribeirão Preto
2020
Universidade Federal de Alfenas
2014-2016
Currently multiresistant Staphylococcus aureus is one common cause of infections with high rates morbidity and mortality worldwide, which directs scientific endeavors in search for novel antimicrobials. In this study, nine extracts from Bidens pilosa (root, stem, flower leaves) Annona crassiflora (rind fruit, leaves, seed pulp) were obtained ethanol: water (7:3, v/v) their vitro antibacterial activity evaluated through both the agar diffusion broth microdilution methods against 60 Oxacillin...
Background: Gut microbiota impacts host homeostasis and diseases. Chronic plus binge ethanol consumption has been linked to increased injuries than chronic or intake alone. We hypothesized that distinct shapes in gut composition are induced by chronic, the association of these treatments, thereby affecting functions contributing sex-based differences alcohol use disorders. Methods: Male female C57BL/6J mice were submitted feeding. DNA was extracted from fecal microbiota, followed analysis...
We tested the hypothesis that ethanol consumption would aggravate renal damage induced by cyclophosphamide (CYP). Male C57BL/6 J mice from control (n = 8) and CYP 12) groups had free access to filtered water standard rodent chow for 12 weeks. Then, 24 h before euthanasia received an intraperitoneal injection of saline or (300 mg/kg). Mice + increasing doses Twenty-four hours euthanasia, CYP, respectively. Ethanol, association both drugs augmented serum levels creatinine increased superoxide...
Overexpression of the inducible isoform enzyme nitric oxide synthase (iNOS) has been associated to pathological processes in kidney. Ethanol consumption induces renal expression iNOS; however, contribution this deleterious effects ethanol kidney remains elusive. We examined whether iNOS plays a role dysfunction and oxidative stress induced by consumption. With purpose, male C57BL/6 wild-type (WT) or iNOS-deficient (iNOS-/-) mice were treated with (20% v/v) for 10 weeks. Treatment increased...
Abstract Aims We investigated the cardiac effects of ethanol withdrawal and possible role AT1 receptors in such response. Methods Male Wistar rats were treated with increasing doses (3 to 9%, vol./vol.) for 21 days. The 48 h after abrupt discontinuation ethanol. Some animals orally losartan (10 mg/kg/day), a selective receptor antagonist. Results Ethanol did not affect serum levels creatine kinase (CK)-MB. Losartan prevented withdrawal-induced increase superoxide anion (O2•−) production left...
Cardiac damage during the acute phase of Chagas disease (CD) is associated with an increase in pro-inflammatory markers and oxidative stress. Melatonin (MEL) has emerged as a promising therapy for CD due to its antioxidant immunomodulatory properties; however, protective action MEL cardiac tissue, well direct on parasite cycle, not fully understood. We investigated effects heart parasitism mice infected Trypanosoma cruzi also parasitic proliferation vitro. Our vivo study showed that reduced...
We tested the hypothesis that ethanol would aggravate deleterious effects of sub-lethal cecal ligation and puncture (SL-CLP) sepsis in cardiorenal system inhibition inducible nitric oxide synthase (iNOS) prevent such response. Male C57BL/6 mice were treated with for 12 weeks. One hour before SL-CLP surgery, N
Purpose: This study aimed to verify whether Adjuvant-Induced Arthritis (AIA) and/or Orchiectomy (ORX) modify the expression of Nox1, Nox2 and Nox4 isoforms, endothelial function or structure rat aortas. Methods: Sixty-three Wistar rats were distributed into four groups: 1) Control; 2) ORX; 3) AIA; 4) plus Arthritis-induction (ORX/AIA). Thus, 21 days after onset AIA (by intradermal injection Mycobacterium tuberculosis), presence Nox4, acetylcholine (ACh)-induced relaxation media layer...